The TNFRSF13C H159Y Variant Is Associated with Severe COVID-19: A Retrospective Study of 500 Patients from Southern ItalyTNFRSF13C H159Y 변이체는 심각한 COVID-19와 관련이 있습니다: 남부 이탈리아에서 온 500명의 환자에 대한 후향적 연구Communication Published on 2021-06-082022-09-10 Journal: Genes [Category] MERS, 변종, 유전자 메커니즘, [키워드] Activation allele analyzed asymptomatic subject B-cell build coding sequence coding sequences contribute COVID-19 CVID disease severity examined genetic determinant genetic determinants genetic risk factor genotyped hospitalized patients Host Humoral immunity identify immunodeficiency involved Italy management mechanism NF-kB non-severe patient pathogenic Point mutation positive predicted rationale risk SARS-CoV-2 Severe case severe COVID-19 Severe patient severe patients severity significant enrichment significantly more SNP genotyping subject the disease therapy TNFRSF13C variant whole-exome sequencing [DOI] 10.3390/genes12060881 PMC 바로가기 [Article Type] Communication
How can human-centered design build a story-based video intervention that addresses vaccine hesitancy and bolsters vaccine confidence in the Philippines? A mixed method protocol for project SALUBONGGlobal Health Published on 2021-06-082022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] administer Analysis approach build childhood Commission Community COVID-19 pandemic dissemination dramatic increase Ethical approval Ethics facilitate Faculty of Medicine group discussion health & safety Health policy health services administration & management healthcare institutional review board Intervention mechanism Medicine Organisation of health services outbreak peer-reviewed polio protocol protocols & guidelines public health public health system questionnaire Research university Vaccinations Vaccine Vaccine hesitancy Vaccines video intervention [DOI] 10.1136/bmjopen-2020-046814 PMC 바로가기 [Article Type] Global Health
Developing a Paper-Based Antigen Assay to Differentiate between Coronaviruses and SARS-CoV-2 Spike Variants코로나바이러스와 SARS-CoV-2 스파이크 변이체를 구별하기 위한 종이 기반 항원 분석 개발Article Published on 2021-06-082022-09-11 Journal: Analytical Chemistry [Category] SARS, 변종, [키워드] Antigen binding build Concentration COVID-19 cross-reactivity Developing diagnostics Factors Final flexible fraction Fractions global pandemic HCoV HCoV-229E HCoV-OC43 HKU1 human saliva human serum immunoassay less lowest media pandemic PCR produced provide robust RT-PCR SARS-CoV-1 SARS-CoV-2 significant effect spike Spike protein Spike proteins test line time-consuming unique various coronaviruses viruses Wuhan Wuhan, China [DOI] 10.1021/acs.analchem.0c05438 PMC 바로가기 [Article Type] Article
COVID-19 vaccines and vaccination: how prepared is Africa?Commentary Published on 2021-06-042022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] acquisition Administered Africa approval build catastrophic COVID-19 COVID-19 pandemic COVID-19 vaccine Emergency use health system Immunity less the vaccine Vaccine Vaccine development Vaccine hesitancy vaccine nationalism Vaccines [DOI] 10.11604/pamj.2021.39.107.27912 PMC 바로가기 [Article Type] Commentary
Machine Learning to Predict In-Hospital Mortality in COVID-19 Patients Using Computed Tomography-Derived Pulmonary and Vascular FeaturesArticle Published on 2021-06-032022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Admission age build Chest computed tomography Chest CT Clinical data computer contributing to COVID-19 COVID-19 patient dataset death died discharge Features highlighting Hospitalization in-hospital mortality lung machine learning machine learning model Mann–Whitney U test median Metrics neural networks outcome parenchymal Patient patients patients who survived performed Precision Predictive Prognosis pulmonary pulmonary artery radiological recall reported SARS-COV-2 infection Stratification Support support vector machine SVM tomography Univariate analysis Vascular Vascular damage vector X-ray computed yielding [DOI] 10.3390/jpm11060501 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspectiveSARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp) 표적화: 인 실리코 관점Article Published on 2021-06-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] Affect anti-viral drug Anti-viral drugs approved drug binding binding affinity build cefuroxime clinically Compound COVID-19 derivative docking drug drug candidates Drug repurposing Effectiveness Efficacy Favipiravir Galidesivir Health Health crisis help Hydroxychloroquine IDX-184 in silico include inhibit SARS-CoV-2 inhibitor molecular molecular docking molecular dynamics Molecular dynamics simulation must New nucleotide Perspective Proteins punch RdRP reduce Remdesivir ribavirin RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 RdRp SARS-CoV-2 RNA Setrobuvir sofosbuvir tenofovir the SARS-CoV-2 Treatment viral infection viral infections Viral protein [DOI] 10.1080/07391102.2020.1761882 PMC 바로가기 [Article Type] Article
Acute Stress Response Profiles in Health Workers Facing SARS-CoV-2Psychology Published on 2021-05-312022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] 95% CI Acute stress Anxiety avoidance build characteristic conducted convenience sampling coronavirus disease COVID-19 COVID-19 outbreak cross-sectional Depression descriptive survey study distress distress symptoms functional GAD-7 Generalized health worker health workers help IES-R Impact impairment Insomnia Insomnia Severity Index Intervention ISI Italy lockdown objective Participants participated PHQ-9 profile profiles psychiatrist psychologist PTSD profiles reported Research Responder response Result risk SARS-CoV-2 self-report measure Sex significant effect significantly higher Symptom worker [DOI] 10.3389/fpsyg.2021.660156 PMC 바로가기 [Article Type] Psychology
Shift to Virtual Self-Management Programs During COVID-19: Ensuring Access and Efficacy for Older AdultsPublic Health Published on 2021-05-312022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] access approach approaches build changed chronic condition Community conditions COVID-19 COVID-19 pandemic daily living distress education effective emotional Ensuring exercise Health healthcare services impacted inactive increase in knowledge Mental MOST Musculoskeletal Musculoskeletal health Older Older adults outcomes pandemic participant Participants physical physical activity physically Program programming provide quarantine reached reported resulting Satisfaction Self-management shift significant difference statistical Virtual [DOI] 10.3389/fpubh.2021.663875 PMC 바로가기 [Article Type] Public Health
Assessing training needs in infectious disease management at major ports, airports and ground-crossings in EuropeResearch Article Published on 2021-05-292022-10-28 Journal: BMC Public Health [Category] Coronavirus, SARS, [키워드] airport analyses Assessing build Complete COVID-19 pandemic education Europe European event exercise Ground-crossing handling highest IHR implementation Importance Infectious disease Infectious disease control International health regulation Likert scale management methodology performed Perspective Points of entry Port preference professional public health emergency public health measures questionnaire representing required respondent Result Simulation supplementary material training Training needs assessment were assessed [DOI] 10.1186/s12889-021-11008-z PMC 바로가기 [Article Type] Research Article
Factors Associated With Racial/Ethnic Group–Based Medical Mistrust and Perspectives on COVID-19 Vaccine Trial Participation and Vaccine Uptake in the US미국의 코로나19 백신 임상시험 참여 및 백신 섭취에 대한 인종/민족 기반 의료 불신과 관련된 요인 및 전망Research Published on 2021-05-272022-09-10 Journal: JAMA Network Open [Category] 임상, [키워드] acceptance Adults age asked association benefit black build Care Community conducted COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine trial COVID-19 vaccine trials Critical cross-sectional survey effort explain Factor finding Gender greater group groups Health Health care highest Importance individual individuals less measure mediator men objective Older organization participant Participants Participation Point populations promote racism receive recruited rejection Relevance reported Research Result scale Separate setting significantly Spread Trial trials Trust uptake vaccination Vaccine vaccine trial white women [DOI] 10.1001/jamanetworkopen.2021.11629 PMC 바로가기 [Article Type] Research