SARS-CoV-2–specific CD8 + T cell responses in convalescent COVID-19 individualsControlled Trial Published on 2021-03-012023-07-01 Journal: The Journal of Clinical Investigation [Category] SARS, [키워드] Cellular immune response COVID-19 immunology MHC class 1 T cells [DOI] 10.1172/JCI145476 PMC 바로가기 [Article Type] Controlled Trial
S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates코로나19 소단위 백신 후보 S-트리머, 비인간 영장류 보호 면역 유도Article Published on 2021-03-012022-09-12 Journal: Nature Communications [Category] SARS, 변종, 비임상, 임상, 진단, 치료기술, 치료법, [키워드] adjuvant alum animal model animal models Antigen AS03 Cellular immune response clinical observation clinical observations controls COVID-19 COVID-19 pandemic CpG effective enveloped RNA viruses host cells immune responses immunization immunized immunogenicity induce Like Lungs Neutralizing antibodies neutralizing antibody non-human primates pandemic platform protective immunity reduction rhesus macaque rhesus macaques RNA viruses Safe SARS-CoV-2 SARS-CoV-2 spike protein Spike protein subunit Subunit vaccine surface antigen TLR9 trimeric Vaccine vaccine candidate Vaccines Viral load viral loads water [DOI] 10.1038/s41467-021-21634-1 PMC 바로가기 [Article Type] Article
COVID-19 in people living with HIV: Clinical implications of dynamics of the immune response to SARS-CoV-2HIV 감염자의 COVID-19: SARS-CoV-2에 대한 면역 반응 역학의 임상적 의미Article Published on 2021-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Admission antiretroviral drugs Antiretroviral therapy CD4+ Cellular immune response clinical clinical picture coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines disease severity dysregulation elicited Evidence evidence of FIVE greater highest HIV HIV infection HIV patients immune activation immune response Immunoglobulin Immunoglobulin G immunological Immunosuppression implication increased risk Inflammatory maximum Mild Nasopharyngeal swab nasopharyngeal swabs Neutralizing antibodies neutralizing antibody occurred on admission Patient patients PLWH Pneumonia Proinflammatory cytokine proinflammatory cytokines protective role reported respiratory Respiratory failure RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 T-cell activation two patients Viral viral clearance with COVID-19 with HIV [DOI] 10.1002/jmv.26556 PMC 바로가기 [Article Type] Article
A Novel DNA Vaccine Against SARS-CoV-2 Encoding a Chimeric Protein of Its Receptor-Binding Domain (RBD) Fused to the Amino-Terminal Region of Hepatitis B Virus preS1 With a W4P MutationW4P 돌연변이가 있는 B형 간염 바이러스 preS1의 아미노 말단 영역에 융합된 수용체 결합 도메인(RBD)의 키메라 단백질을 암호화하는 SARS-CoV-2에 대한 새로운 DNA 백신Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 변종, 진단, [키워드] Against BAL Blood Bronchoalveolar lavage caused cell-mediated immune response Cellular immune response chimeric coronavirus coronavirus SARS-CoV-2 COVID-19 demonstrated develop disease DNA DNA vaccine domain effective encoding evaluated experiment expressing feasibility fused global public health HBV HBV preS1 hepatitis B Hepatitis B virus highlighting humoral IgA IgG IL-6 immune responses Infection lung mice multiple cell line Mutation N-terminal neutralize novel pandemic Pneumonia PROTECT Protein RBD RBD protein Receptor-binding domain Receptor-binding domain (RBD) Region robust S1 protein Safe SARS-CoV-2 SARS-COV-2 infection sequence sera significantly TNFα Transcription translation Vaccine Viral Viral pneumonia W4P-RBD wild-type [DOI] 10.3389/fimmu.2021.637654 PMC 바로가기 [Article Type] Immunology
Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in RussiarAd26 및 rAd5 벡터 기반 이종 프라임-부스트 COVID-19 백신의 안전성 및 효능: 러시아의 무작위 대조 3상 시험 중간 분석Clinical Trial Published on 2021-02-202022-09-12 Journal: Lancet (London, England) [Category] Fulltext, MERS, 임상, 진단, [키워드] 95% CI Administered adverse event age Analysis assigned available data case report form Cellular immune response city clinical trials COVID-19 database death Department Direct dose double-blind Efficacy Efficacy and safety enrolment events excluded first dose full-length SARS-CoV-2 Gam-COVID-Vac glycoprotein Heterologous heterologous prime-boost hospital humoral IgG and IgM independent Infectious disease interim analysis intramuscularly Investment large cohort MOST participant Participants PCR-confirmed COVID-19 phase 3 trial Placebo placebo-controlled Primary outcome primary outcome analysis proportion protocol randomised randomised controlled Randomly receive receiving recombinant adenovirus Registered reported Russia Safety safety profile SARS-CoV-2 PCR second dose Serious Adverse Event Stratification the placebo group the vaccine Trial vaccination Vaccine vector were assessed [DOI] 10.1016/S0140-6736(21)00234-8 PMC 바로가기 [Article Type] Clinical Trial
Restoration of type I interferon signaling in intrahepatically primed CD8 + T cells promotes functional differentiationResearch Article Published on 2021-02-082023-06-03 Journal: JCI Insight [Category] B형 간염, Fulltext, [키워드] Cellular immune response Hepatitis immunology Infectious disease T cells [DOI] 10.1172/jci.insight.145761 PMC 바로가기 [Article Type] Research Article
Correlates of protection against SARS-CoV-2 in rhesus macaques붉은 털 원숭이에서 SARS-CoV-2에 대한 보호 상관 관계Article Published on 2021-02-012022-09-12 Journal: Nature [Category] MERS, SARS, 진단, [키워드] abrogated acute respiratory syndrome Antibody Response Antibody titre antibody titres CD8 Cellular immune response cellular immunity contribute convalescent coronavirus Depletion dose-dependent Efficacy humoral IgG Immunity implication infection with SARS-CoV-2 macaque macaques natural immunity PROTECT Protective purified recent reported required rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine T cell therapeutic agents transfer Treatment [DOI] 10.1038/s41586-020-03041-6 PMC 바로가기 [Article Type] Article
Induction of SARS-CoV-2 Protein S-Specific CD8+ T Cells in the Lungs of gp96-Ig-S Vaccinated Micegp96-Ig-S 백신 접종 마우스의 폐에서 SARS-CoV-2 단백질 S-특이적 CD8+ T 세포의 유도Immunology Published on 2021-01-262022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] airways Allogeneic Antigen CD4+ CD8+ CD8+ T cell CD8+ T cells Cell Cell-mediated immune responses cellular Cellular immune response chaperone COVID-19 deaths expressing full-length protein generate glycoprotein glycoprotein 96 Heat shock heat shock protein humans immune system IMPROVE induce induction leukocyte lung Lungs measure observation Protein protein S public health response robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 protein SARS-CoV-2 protein S secreted Spread stimulate Support the vaccine transgenic mice translational Vaccine vaccine candidate vaccine platform [DOI] 10.3389/fimmu.2020.602254 PMC 바로가기 [Article Type] Immunology
Recent endemic coronavirus infection is associated with less-severe COVID-19최근의 풍토병 코로나바이러스 감염은 덜 심각한 COVID-19와 관련이 있습니다Article Published on 2021-01-042022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, 진단, 치료기술, [키워드] acquisition Adaptive immunity Cellular immune response common cold coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infection COVID-19 disease manifestation Endemic endemic human coronavirus endemic human coronaviruses etiologic agents Frequency greater immune response immune responses individual Infection mitigate observation recent respiratory respiratory infection respiratory infections SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-COV-2 infection sequence homology severe coronavirus disease tested the patient [DOI] 10.1172/JCI143380 PMC 바로가기 [Article Type] Article
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets붉은털원숭이, 개코원숭이 및 마모셋 폐의 SARS-CoV-2 급성 감염에 대한 반응Article Published on 2021-01-012022-09-12 Journal: Nature Microbiology [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome adaptive age antibody Baboon Bronchoalveolar lavage bystander Cellular immune response Clinical sign clinical trials Computed tomography coronavirus coronavirus disease COVID-19 cytokine production cytokine response distress group humans Immune cell immunohistochemical analyses Infection interferon response lung Lung inflammation Lungs macaque macaques memory Mild moderate Non-human Pathologies progression response rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG T-cell Therapies titre Vaccine viral infection Viral RNA shedding was increased [DOI] 10.1038/s41564-020-00841-4 PMC 바로가기 [Article Type] Article