Non-covalent SARS-CoV-2 M pro inhibitors developed from in silico screen hits
Article
[키워드] acute respiratory syndrome
analogues
binding
chemotype
clinically
Compound
coronavirus
culture cells
denatured
described
effort
evaluated
examined
FIVE
group
identify
in silico
in vitro
inhibit
inhibited
inhibitor
inhibitors
M pro
performed
protease
Protease activity
Replication
SARS-CoV-2
SARS-CoV-2 infections
Screening
selected
Small molecules
suppressed
temperature
the SARS-CoV-2 virus
these compound
tissue
treat
viral life cycle
was determined
X-ray crystallography
[DOI] 10.1038/s41598-022-06306-4 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41598-022-06306-4 PMC 바로가기 [Article Type] Article