An aberrant STAT pathway is central to COVID-19
Reviews
[키워드] activate
Activation
affected
age
approved drugs
ARDS
Autopsy
bind
cardiovascular diseases
cascade
catastrophic
caused
characterized
chemokines
clinical development
Clinical symptoms
Coagulopathy
component
COVID-19
DAD
diabetes
Diffuse alveolar damage
drug
dysfunction
EGFR
Endothelial cell
ENhance
function
Hyperactivation
hypertension
hypoxic environment
IFN-I
induce
Infection
inhibit
initiated
innate immune cell
interferon
lung
Lung injury
macrophages
nsp1
obesity
ORF6
pathophysiology
pathway
Perspective
Phosphorylation
positive feedback loop
Proinflammatory cytokine
Proteins
recruitment
risk factor
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2-infected cells
secretion
Severe case
Signaling
STAT
Stat1
STAT3
stimulate
subsequent
TLR4
Transcription
treat
Treatment
Type
upregulation
widespread
[DOI] 10.1038/s41418-020-00633-7 [Article Type] Reviews
[DOI] 10.1038/s41418-020-00633-7 [Article Type] Reviews