In Silico Drug Repositioning to Target the SARS-CoV-2 Main Protease as Covalent Inhibitors Employing a Combined Structure-Based Virtual Screening Strategy of Pharmacophore Models and Covalent DockingSilico 약물 재배치에서 SARS-COV-2 주 프로테아제를 표적화하여 약물 코어 모델 및 공유 도킹의 결합 된 구조 기반 가상 스크리닝 전략을 사용하는 공유 억제제로서Article Published on 2022-04-032022-08-31 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Adding affinity appearance Bicalutamide caused Cimetidine cleavage CMX-2043 Combined complex conserved coronavirus covalent binding covalent inhibitors Cys145 cysteine docking drug drug repositioning DrugBank drugs effective Efficacy Efficiency electrophilic energy contribution energy contributions Epidemic FDA FDA-approved drug FDA-approved drugs identify inhibitor inhibitor N3 inhibitors inhibitors of SARS-CoV-2 Interaction Ixazomib limit M pro mechanism Michael Model molecular MPro pharmacophore pharmacophore modeling Probability protease proteinase provided Replication repositioning required SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 Mpro Scopolamine Screening Spread Strategy Structure-based virtual screening target the SARS-CoV-2 therapeutic target Treatment Vaborbactam Vaccines variety Viral viral variant Viral variants Virtual screening [DOI] 10.3390/ijms23073987 PMC 바로가기 [Article Type] Article
The variants of SARS-CoV-2 and the challenges of vaccinesSARS-CoV-2의 변종과 백신의 도전Review Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Economy Effectiveness effort Epidemic Health outbreak Prevention and control provide Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein suffered the SARS-CoV-2 Vaccine Vaccine development Vaccines variant variants variants of SARS-CoV-2 [DOI] 10.1002/jmv.27513 PMC 바로가기 [Article Type] Review
Timely treatment and higher compliance to traditional Chinese medicine: New influencing factors for reducing severe COVID-19 based on retrospective cohorts in 2020 and 2021Research article Published on 2022-04-012022-10-05 Journal: Pharmacological research [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] addition adhere age Antibiotics antiviral medicine association calculated changed characterized Chinese cohort study cohorts collected Compliance Concomitant medication conditions conducted control limit COVID-19 patient COVID-19 patients diagnosed Diagnosis disease E-value effective Effectiveness enrolled Epidemic Factor Final hospital Hospitalization Hospitalized incidence independent risk factor initial symptom initial symptoms LCL less measure Mild mild COVID-19 Moderate COVID-19 multivariate logistic regression New objective outcome participant Patient predict Prognosis progressed proportion public health reduced reducing Result retrospective cohort retrospective cohort study sensitivity analysis Severe case severe cases severe COVID-19 Severity of disease Sex TCM The proportion to severe status Traditional Chinese medicine treat Treatment were used Wuhan [DOI] 10.1016/j.phrs.2022.106174 [Article Type] Research article
Improving vaccination coverage and offering vaccine to all school-age children allowed uninterrupted in-person schooling in King County, WA: Modeling analysisArticle Published on 2022-04-012022-11-16 Journal: Mathematical biosciences and engineering : MBE [Category] COVID19(2023년), SARS, 변종, [키워드] addition age age structured model Analysis analyzed benefit calibrated changes in children Coverage COVID-19 COVID-19 vaccination Critical dynamic Epidemic Epidemiology Health Hospitalization hospitalizations Improving Interaction IQR King limit mathematical mathematical modeling measure median modeling morbidity and mortality physical PPI predicted Prevent proportion provide Rapid reached reduce reducing reduction reported restored SARS-CoV-2 transmission SARS-CoV-2 variant School social distancing Social distancing measure Spread the epidemic trajectory USA vaccinate vaccination Vaccine variants of concern Washington [DOI] 10.3934/mbe.2022266 PMC 바로가기
Electrochemical biosensor for nucleic acid amplification-free and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA via CRISPR/Cas13a trans-cleavage reactionCRISPR/Cas13a trans-cleavage 반응을 통한 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) RNA의 핵산 증폭이 없고 민감한 검출을 위한 전기화학 바이오센서Article Published on 2022-04-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 artificial saliva biosensor cleave complex Concentration coronavirus COVID-19 COVID-19 pandemic CRISPR CRISPR/Cas13a detect diagnostic diagnostic testing dynamic range electrochemical biosensor Epidemic evaluated fatality Genes gold identify introduced nucleic acid occur ORF outbreak probe RNA RNase Saliva SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus ssRNA Trans-cleavage activity. Transmission Trigger virus detection [DOI] 10.1016/j.bios.2021.113960 PMC 바로가기 [Article Type] Article
Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2SARS-CoV-2의 PLPro에 대한 클로로퀴논과 하이드록시클로로퀴논의 결합에 대한 전산 조사Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Amino acid amino acid residue anticipated approved binding binding affinity carried Chloroquine cleavage complex conformational coronavirus SARS-CoV-2 COVID-19 docked drug target effective Epidemic FDA FDA approved drug HCQ Hydroxychloroquine identify Immune suppression inhibitor inhibitors of SARS-CoV-2 integrity involved MDs mechanism mechanism of action molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations molecular target Mortality MPro novel Novel coronavirus pandemic Papain PLPro polyprotein processing protease repurposing rising SARS-CoV-2 SARS-CoV2 Simulation study the SARS-CoV-2 therapeutic interventions therapeutic targeting [DOI] 10.1080/07391102.2020.1844804 PMC 바로가기 [Article Type] Article
Epidemiology of COVID-19 among health personnel in long-term care centers in SevilleObservational Study Published on 2022-04-012022-10-04 Journal: Revista clínica española [Category] COVID19(2023년), SARS, 임상, [키워드] Affect calculated Care caused Centros sociosanitarios Clinical characteristics confidence interval Coronavirus disease 2019 coronavirus SARS-CoV-2 cough COVID-19 cumulative disease English Epidemic Epidemiología epidemiological epidemiological survey Epidemiology evaluate Fever Health healthcare implementation incidence information Isolation majority measure Measures median Mild symptom Nursing nursing homes Nursing staff onset of symptom outbreak Outbreaks para Personal de enfermería. SARS-COV-2 infection Sociodemographic Spain Spanish Spread statistical analysis statistical hypothesis Surveillance Symptom the disease Transmission were used women [DOI] 10.1016/j.rceng.2021.06.006 PMC 바로가기 [Article Type] Observational Study
Circulating pediatric respiratory pathogens in Taiwan during 2020: Dynamic change under low COVID-19 incidenceResearch article Published on 2022-04-012022-10-05 Journal: Journal of microbiology, immunology, and infection [Category] 치료기술, [키워드] Adenovirus Analysis changes in children circulation clinical symptom confirmed COVID-19 case continuous surveillance COVID-19 COVID-19 incidence detection rate dropped dynamic enrolled Epidemic Epidemiology evolutionary dynamics Fever hospital immunochromatographic assay lateral flow Measures multiplex Nasopharyngeal swab non-enveloped virus nonpharmaceutical intervention Nonpharmaceutical interventions outbreak pandemic parainfluenza virus PCR pediatric performed polymerase chain remained Respiratory illness respiratory pathogen Respiratory pathogens respiratory syncytial virus respiratory virus Result retrospective cohort study RSV Taiwan tested unique virus [DOI] 10.1016/j.jmii.2022.03.005 [Article Type] Research article
Lessons learned from three avian influenza simulation exercises in the southwest of FranceArticle Published on 2022-04-012023-06-01 Journal: Preventive veterinary medicine [Category] 조류인플루엔자, [키워드] Avian Influenza collective action Epidemic feedback prevention Simulation exercise [DOI] 10.1016/j.prevetmed.2022.105595
An in-depth statistical analysis of the COVID-19 pandemic’s initial spread in the WHO African regionWHO 아프리카 지역에서 COVID-19 전염병의 초기 확산에 대한 심층 통계 분석Article Published on 2022-04-012022-09-11 Journal: BMJ Global Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] African attack rate attack rates case fatality ratio CFR Containment measure country COVID-19 COVID-19 pandemic cross-sectional cross-sectional study cross-sectional survey cumulative death described driver effective Epidemic Epidemiology First wave FIVE Government greater growth Growth period Health implementation initial mathematical Mathematical modelling member Older pandemic populations predictor variable public health reduction regression analysis Resilience SARS-COV-2 infection SARS-CoV-2 infections severity Spread stability state statistical analysis Surveillance tested the WHO threat Variation virus WHO [DOI] 10.1136/bmjgh-2021-007295 PMC 바로가기 [Article Type] Article