Influence of thromboembolic events in the prognosis of COVID-19 hospitalized patients. Results from a cross sectional studyResearch Article Published on 2021-06-092022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age AIS association chronic obstructive Comorbidity Complication COVID-19 COVID-19 infection cross cross-sectional D-dimer defined diabete died evaluated exhibited hospitalized COVID-19 patient hospitalized patient hospitalized patients ICU care In-hospital death increased risk influence Myocardial infarction objective Occurrence Odds ratio Older Patient Prevalence Prognosis Protein pulmonary disease regression models report Result Spain stroke systemic arterial embolism Thromboembolic event Thromboembolism thrombosis thrombotic complication TTE venous Venous Thromboembolism VTE with COVID-19 [DOI] 10.1371/journal.pone.0252351 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive careSARS-CoV-2 RNA혈증 및 단백질 궤적은 중환자실에 입원한 COVID-19 환자의 예후를 알려줍니다Article Published on 2021-06-072022-09-10 Journal: Nature Communications [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjusted age and sex Antibody Response antiviral properties best binding blood sample Blood samples cell-cell fusion Characteristics comparable Comparisons complement Complement pathway complement system controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient galectin-3 hazard ratio healthy control healthy controls hospitalized COVID-19 patient hospitalized COVID-19 patients ICU ICU patient ICU Patients in vitro inhibit innate immune system intensive care intensive care unit interaction partner LGALS3BP machine machine learning mannose mass spectrometry Mortality Neutralizing antibody response Non-COVID-19 overexpression Patient plasma predict predictors Prognostic markers Protein proteomic Ptx3 respiratory risk stratification RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike glycoprotein Sepsis sepsis patient serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike glycoprotein survival trajectory Viral Viral RNA [DOI] 10.1038/s41467-021-23494-1 PMC 바로가기 [Article Type] Article
PD-L1 Dysregulation in COVID-19 PatientsImmunology Published on 2021-06-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adaptive immune response ARDS biological sample blood sample caused CD4+ T cells clinical study consequence COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient cultures dysregulated dysregulated immune response dysregulation effective epithelial cell Evidence healthy donors healthy individuals hospitalized COVID-19 patient Host immune response identify Immune cell immune checkpoint molecules in vitro Infection inhibitors innate immune response Ligand manifestation Manifestations model system modulation Monocytes Neutrophils Patient PD-L1 Prognosis prognostic prognostic biomarker reached RNA expression SARS-CoV-2 Serum level subset T cell therapeutic approaches tissue tissue biopsy upregulation variety [DOI] 10.3389/fimmu.2021.695242 PMC 바로가기 [Article Type] Immunology
Efficacy and Safety of Hydroxychloroquine for Hospitalized COVID-19 Patients: A Systematic Review and Meta-AnalysisReview Published on 2021-06-052022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI adverse events all-cause mortality analyses caused clearance clinical recovery Controlled trial controls COVID-19 discharge dose Efficacy and safety Hospitalization hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients Hydroxychloroquine ICU admission increased mortality inverse mechanical ventilation Meta-analysis Mortality non-invasive ventilation not affect outcome oxygen support performed Pneumonia radiological progression random effect ranged RCT RCTs review SAE Safety searched secondary Secondary outcomes Serious Adverse Event severe adverse events significantly higher subgroup analysis Treatment worsening [DOI] 10.3390/jcm10112503 PMC 바로가기 [Article Type] Review
Convalescent plasma use in the USA was inversely correlated with COVID-19 mortality미국의 회복기 혈장 사용은 COVID-19 사망률과 반비례합니다Research Article Published on 2021-06-042022-09-10 Journal: eLife [Category] MERS, SARS, 변종, [키워드] Admission age authority authorization Blood CCP change convalescent plasma correlated COVID COVID-19 death deaths declined Department development drug Drug administration Emergency Emergency use authorization EUA Evidence examination Expanded access Expanded Access Program explain food funding hospital Hospital admission Hospital admissions hospitalized COVID-19 patient hospitalized COVID-19 patients Human Inpatient Inpatients inverse correlation less Mortality mortality data nadir office organization pandemic Patient peaked plasma provide Randomized controlled trial Randomized controlled trials reduce reduction in mortality research and development robust SARS-CoV-2 variants Secretary supported therapy US Food and Drug Administration USA Usage virus infection with COVID-19 [DOI] 10.7554/eLife.69866 PMC 바로가기 [Article Type] Research Article
Cytokine and interleukin profile in patients with headache and COVID-19: A pilot, CASE-control, study on 104 patientsObservational Study Published on 2021-06-042022-10-04 Journal: The Journal of Headache and Pain [Category] MERS, SARS, 임상, [키워드] accounted acute phase Admission age Anosmia anti-inflammatory cytokine baseline both groups clinical variable control group Course COVID-19 COVID-19 disease COVID-19 severity cytokine cytokine release Cytokines disorder dispersion parameter explained female Fever Frequency headache Headache disorders hospital Hospitalization hospitalized COVID-19 patient IL-10 IL-21 IL-22 IL-23 immune response immune system in both groups innate response Interleukins median value Patient patients plasma extraction remained Result Sex statistically significant supplementary material the disease two groups viral infection was performed [DOI] 10.1186/s10194-021-01268-w PMC 바로가기 [Article Type] Observational Study
Adherence to COVID-19 Nutrition Guidelines Is Associated with Better Nutritional Management Behaviors of Hospitalized COVID-19 PatientsArticle Published on 2021-06-032022-10-30 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] adherence adjusted Behavior Better boost Care Clinical practice conducted coronavirus coronavirus disease COVID-19 COVID-19 patients dietary intake Good guideline guidelines adherence hospitalized COVID-19 patient hospitalized COVID-19 patients immune system Immunity implementation Indonesia knowledge lack Length of stay Linear regression management medical record Mortality multicenter nutrition nutrition care pandemic performed predicted Stress Support [DOI] 10.3390/nu13061918 PMC 바로가기 [Article Type] Article
Nutrition in the Actual COVID-19 Pandemic. A Narrative ReviewReview Published on 2021-06-032022-10-30 Journal: Nutrients [Category] COVID-19, MERS, SARS, [키워드] actual addition articles B12 body composition Complete conducted Consensus COVID-19 COVID-19 pandemic Critical deficiency dietary change dietary pattern Factor Fatty acid Google Scholar Gut Health Health authority highlighting hospitalized COVID-19 patient immunology implication increased risk increases in Intervention literature review lockdown Malnutrition medium narrative nutrition obesity omega-3 pandemic patients with COVID-19 physical activity physical activity level promoted Research review SciELO Treatment Vitamin Vitamin C with COVID-19 [DOI] 10.3390/nu13061924 PMC 바로가기 [Article Type] Review
Tocilizumab in Hospitalized Patients with COVID-19: A Meta Analysis of Randomized Controlled TrialsCOVID-19로 입원한 환자의 토실리주맙: 무작위 대조 시험의 메타 분석Meta-Analysis Published on 2021-06-012022-09-12 Journal: Lung [Category] MERS, SARS, 진단, [키워드] 95% CI added addition all-cause mortality Analysis Controlled Coronavirus disease-19 COVID-19 COVID-19 patients database Dexamethasone discharge Efficacy hospital discharge hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient IL-6 IMPROVE Infection mechanical ventilation median time Meta Meta-analysis morbidity Mortality outcome Patient patients Placebo progression Randomized controlled trial reduce mortality risk searched shown significantly Standard therapy therapeutic intervention therapy Tocilizumab tocilizumab therapy treatment guideline with COVID-19 [DOI] 10.1007/s00408-021-00451-9 PMC 바로가기 [Article Type] Meta-Analysis
Clinical features and outcomes of hospitalized COVID-19 patients in a low burden region저부담 지역 입원한 코로나19 환자의 임상 양상 및 결과Observational Study Published on 2021-06-012022-09-11 Journal: Pathogens and global health [Category] SARS, 임상, 치료제, [키워드] Admission age Analysis Chest chest X-ray clinical Clinical data clinical feature Clinical features Comorbidity country COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Critical disease death died disease European country Factor feature Greece hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hypertension ICU ICU admission ICU care Immunosuppression In-hospital death independent predictor independent predictors independent risk factor independent risk factors intensive care unit invasive ventilation lower mortality lung field male median medical record medical records Mortality multivariable logistic regression outbreak outcome pandemic Patient patients hospitalized Pneumonia Region reported required Respiratory failure Retrospective study SARS-CoV2 Solid solid tumor the disease thrombocytopenia Tumor univariable [DOI] 10.1080/20477724.2021.1893485 PMC 바로가기 [Article Type] Observational Study