Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In VivoVaccines and Antiviral Agents Published on 2018-09-122022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] avian infectious bronchitis virus BeauR bronchitis cause cellular challenge Characteristics characterized chimeric ciliary Clinical sign Clinical signs conducted conformational contagious coronavirus cross-protection determine expressing glycoprotein Heterologous homologous IBV IMPROVE in vitro in vivo induce Limited Live attenuated vaccines M41 mucosal tissue Partial partial protection PROTECT protective immunity recombinant recombinant vaccine reduction in reductions in replicated Replication Respiratory disease responsible rIBV S1 S1 and S2 S2 subunit serotype serum serum antibody single vaccination spike strain surface protein the S1 subunit tracheal Trial vaccination Vaccine Viral load viral RNA load virulent virus [DOI] 10.1128/JVI.01473-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Porcine epidemic diarrhea virus inhibits dsRNA-induced interferon-β production in porcine intestinal epithelial cells by blockade of the RIG-I-mediated pathwayResearch Published on 2015-08-182022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Activation adapter African green monkey antiviral immune response blockade blocked cell line damaged demonstrated digestive disorders epidemic diarrhea epithelial cell expression Host identify IFN IFN-β immune cell population immune function in vitro in vivo induce Infection inhibit inhibited inhibitor of κB innate immune system Interaction interferon Intervention intestinal epithelia intestinal epithelial cell intestinal epithelial cells investigated kidney kinase-ε lack Limited mechanism molecular mechanism NF-κB nuclear offered Pathogenesis pathway PEDV promoter Regulatory Result RIG-I signaling pathway target cell transcription factors Type type I interferon upstream Vero Cell virus were used [DOI] 10.1186/s12985-015-0345-x PMC 바로가기 [Article Type] Research
Distinct Characteristics and Complex Evolution of PEDV Strains, North America, May 2013–February 2014Research Published on 2014-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] Analysis analyzed Characteristics clade clades Cluster Complete complete genome analysis Deletion determine epidemic diarrhea Genome heterogeneity identity initial insertion introduced Limited molecular North North America open reading frame 1 ORF 1 PEDV PEDV variant Phylogenetic analysis PIGS Porcine epidemic diarrhea virus recombination identification analysis reported S INDEL strains sequenced single nucleotide polymorphisms spike gene Spread strain Strains the United State The United States US strains variants virulent virulent strains virus viruses [DOI] 10.3201/eid2010.140491 PMC 바로가기 [Article Type] Research