COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of MetforminMedicine Published on 2021-02-192022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute ischaemic stroke addition AIS biochemical Coagulopathy coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 symptom CRP Cytokine storm D-dimer diabates mellitus diabetic patient displaying Endothelial dysfunction evaluated independent risk factor Ischemic LDH lower risk lung CT scan metformin observé Patient patients with COVID-19 plaque instability radiological recruited retrospective cohort study role SARS-CoV-2 Serum level stroke therapy treated patient treated patients Type type 2 diabete [DOI] 10.3389/fmed.2021.644295 PMC 바로가기 [Article Type] Medicine
Early risk assessment for COVID-19 patients from emergency department data using machine learningArticle Published on 2021-02-182022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Admission age analysed applied Blood caused characteristic clinical Clinical characteristics Clinical data clinical endpoint clinical feature clinical variable collected Computational biology and bioinformatics coronavirus COVID-19 COVID-19 patient creatinine death demographic data Deterioration Diseases EHR EHR data electronic healthcare record England epidemiological evaluate extreme high accuracy hospital in-hospital mortality inclusion criteria increased risk Infectious diseases initial intensive care Invasive mechanical ventilation laboratory result Laboratory results Lactate London lower risk machine learning majority measure mechanical ventilation Medical research Mild Mortality multivariate logistic regression NHS outcomes oxygen supply oxygenation status pandemic Patient patient age physiological poor prognosis predict predicted Predictive Prognostic markers random receiving reported required Retrospective study risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 positive patient selected severe disease Trajectories Translational research Trust used data Ventilation viral infection while [DOI] 10.1038/s41598-021-83784-y PMC 바로가기 [Article Type] Article
Depressive and Anxiety Symptoms Among People Under Quarantine During the COVID-19 Epidemic in China: A Cross-Sectional StudyPsychiatry Published on 2021-02-152022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] adverse effects Anxiety anxiety symptom anxiety symptoms applied CDA China Chinese Combination Compliance conducted coronavirus disease correlated COVID-19 COVID-19 pandemic cross-sectional study Depression depressive dissemination effective GAD-7 Generalized identify individual knowledge less logistic regression model lower risk Measures moderate Multivariate analysis pandemic participant PHQ-9 Population prevalent Psychological public health measure quarantine Spread suffered symptoms of depression virus was performed [DOI] 10.3389/fpsyt.2021.566241 PMC 바로가기 [Article Type] Psychiatry
Dietary Intake and Mental Health among Saudi Adults during COVID-19 LockdownArticle Published on 2021-02-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] age Anxiety conducted consequence continuous monitoring COVID-19 COVID-19 pandemic cross-sectional Depression dietary dietary intake elevated Healthcare provider high risk higher risk identify Insomnia intake lockdown lower risk median Mental mental illness multivitamin pandemic participant predictor Prevalence Psychological regression analysis required SAR Saudi Arabia student Support was used [DOI] 10.3390/ijerph18041653 PMC 바로가기 [Article Type] Article
Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study Research Published on 2021-02-042022-10-05 Journal: Molecular Psychiatry [Category] SARS, 임상, 진단, 치료제, [키워드] 95% CI adjusted adults hospitalized Analysis Antiviral effect AP-HP association biological marker Characteristics conducted COVID-19 Cox model death depressive disease severity disorder Endpoint epithelial cell examined Hospital admission hospitalized patient hospitals In-vitro Infection inhibit intubation lower risk medication Meta-analysis multicenter multiple sensitivity analyses multivariable Paris Patient patients hospitalized plasma Prevent primary analysis primary endpoint pro-inflammatory mediators Probability psychotropic medications randomized clinical trial recent reduced reduced risk remained retrospective cohort study SARS-CoV-2 severe COVID-19 university Weighting [DOI] 10.1038/s41380-021-01021-4 [Article Type] Research
Effects of tocilizumab on mortality in hospitalized patients with COVID-19: a multicentre cohort studyCOVID-19로 입원한 환자의 사망률에 대한 토실리주맙의 효과: 다기관 코호트 연구Multicenter Study Published on 2021-02-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval adjusted adjusted hazard ratio Admission analysed Analysis association baseline C-reactive protein C-reactive protein (CRP causal relationship clinical trial clinical trials cohort study control group coronavirus disease Coronavirus disease 2019 covariate COVID-19 CRP CRP levels death deaths determine Effect Efficacy Exploratory subgroup analyses hazard ratio hospitalized patient hospitalized patients ICU ICU admission implication intensive care intensive care unit investigated large cohort lower risk Mortality multicentre observational study outcome Patient patients hospitalized patients with COVID-19 point estimate point estimates Primary outcome Probability receipt risk of death SARS-CoV-2 secondary outcome severe coronavirus disease significant interaction Spain systemic inflammation therapy Tocilizumab Weighting while with COVID-19 [DOI] 10.1016/j.cmi.2020.09.021 PMC 바로가기 [Article Type] Multicenter Study
A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single centerObservational Study Published on 2021-02-012022-10-05 Journal: Journal of autoimmunity [Category] SARS, 임상, [키워드] 95% CI acute respiratory syndrome Admission Adverse adverse outcome age age and gender analyzed association Autoimmune Autoimmune diseases Barcelona Cohort cohort of patient Comorbidity composite endpoint conducted Control coronavirus covariate COVID-19 database death discrepancy Factor hospital Hospitalization ICU ICU admission immune-mediated disease Immune-mediated inflammatory disease Immunosuppression Infection intensive care Local Logistic regression analysis lower risk mechanical ventilation multivariate model outcomes Patient Prevalence Primary outcome retrospective risk SARS-CoV-2 SARS-COV-2 infection selected sensitivity analysis severe acute respiratory syndrome coronavirus 2 severe disease severe SARS-CoV-2 Sex single center Sociodemographic Spain symptomatic symptomatic SARS-CoV-2 infection therapeutic university was performed [DOI] 10.1016/j.jaut.2020.102580 PMC 바로가기 [Article Type] Observational Study
Beliefs and Risk Perceptions About COVID-19: Evidence From Two Successive French Representative Surveys During LockdownPsychology Published on 2021-02-012022-10-31 Journal: Frontiers in Psychology [Category] COVID-19, [키워드] belief beliefs catch comparative optimism concomitant increase COVID-19 COVID-19 pandemic deviation diagnosed disease elicit Evidence expected explain fatality France French IFR individual Infection lockdown lower risk optimism outbreak own risk Perception Prevalence prevalence rate Probability provide rational learning remained Result risk Risk perception Spread survey the disease trade-off wearing face mask were measured while with COVID-19 [DOI] 10.3389/fpsyg.2021.619145 PMC 바로가기 [Article Type] Psychology
Repurposed Tocilizumab in Patients with Severe COVID-19중증 COVID-19 환자의 용도 변경 TocilizumabObservational Study Published on 2021-02-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] MERS, SARS, 신약개발, 임상, 진단, 치료기술, [키워드] 95% confidence interval activated activated partial thromboplastin time acute respiratory distress acute respiratory distress syndrome age aggravate C-reactive protein caused Comorbidities Comorbidity Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine release syndrome Cytokine storms Disease progression dysregulated Effectiveness elevated Evidence fibrinogen global pandemic hazard ratio IL-6 Immune cell immune cells In-hospital death Inflammation inhibitor inhibitor of IL-6 lower risk morbidity and mortality Observational cohort study Odds ratio partial thromboplastin time Patient patients with COVID-19 Propensity score provided Randomized receiving respiratory distress Respiratory distress syndrome resulting retrospective risk robust severe COVID-19 severely ill patient severely ill patients Sex survival syndrome the cytokine storm THROMBOPLASTIN Tocilizumab tocilizumab administration Treatment Wuhan Wuhan, China [DOI] 10.4049/jimmunol.2000981 PMC 바로가기 [Article Type] Observational Study
Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine ImmunizationReview Published on 2021-01-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] addition amelioration of disease contribute current disease effective vaccine facilitate Factors Genetic immune correlate immune responses Immunity induce Infection innate immune Innate immunity Local lower risk mucosal mucosal immunity neutralizing antibody Neutralizing antibody titer Potential protection robust SARS-CoV-2 SARS-COV-2 infection severity suggested sustained T-cell immunity Th1 response Th1 responses trained immunity type I interferon type I interferons Vaccine Viral transmission [DOI] 10.3390/pathogens10020138 PMC 바로가기 [Article Type] Review