Omicron Binding Mode: Contact Analysis and Dynamics of the Omicron Receptor-Binding Domain in Complex with ACE2오미크론 결합 모드: ACE2와 복합된 오미크론 수용체 결합 도메인의 접촉 분석 및 역학Article Published on 2022-08-222022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies B.1.1.529 binding complex complexes Contact COVID-19 Department distribution domain Dynamics edge Effect electrostatic form H-bond host receptor human ACE2 IMPROVE Interaction Lineage molecular molecular dynamics Mutation mutations N501Y omicron Omicron variant Open Science Framework Protein Proteins Receptor-binding domain resistance S-RBD Salt Bridge salt bridges SARS-CoV-2 virus spike Spike protein Spike proteins Stanford the receptor-binding domain the SARS-CoV-2 virus the Spike the WHO unique variant VoC [DOI] 10.1021/acs.jcim.2c00397 PMC 바로가기 [Article Type] Article
Development of a panel of three multiplex allele-specific qRT-PCR assays for quick differentiation of recombinant variants and Omicron subvariants of SARS-CoV-2Article Published on 2022-08-182022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] allele allele-specific qRT-PCR amplification analytical sensitivity applied BA.1 subvariant BA.2 subvariant circulating variant coefficient costly CVs development Efficiency exhibited Limits of detection linear MONITOR multiplex mutated Mutation omicron Omicron variant qRT-PCR qRT-PCR assay reaction real time recombinant variant. reproducibility required RT-PCR Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant Sequencing sequencing method SNP genotyping time-consuming Transmission variant variants variants of SARS-CoV-2 Variation whole genome [DOI] 10.3389/fcimb.2022.953027 PMC 바로가기
Immunogenicity and reactogenicity of heterologous immunization against SARS CoV-2 using Sputnik V, ChAdOx1-S, BBIBP-CorV, Ad5-nCoV, and mRNA-1273Sputnik V, ChAdOx1-S, BBIBP-CorV, Ad5-nCoV 및 mRNA-1273을 사용한 SARS CoV-2에 대한 이종 면역의 면역원성과 반응성Article Published on 2022-08-162022-09-11 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] Ad5-nCoV analyzed Anti-spike Antibody Response BBIBP-CorV ChAdOx1 ChAdOx1 vaccine ChAdOx1-S Cohort Combination coronavirus disease Coronavirus disease 2019 Coverage COVID-19 evaluate Heterologous heterologous vaccination heterologous vaccine highest homologous humoral Humoral response IgG immunization immunogenicity Immunoglobulin Immunoglobulin G information Messenger RNA mRNA mRNA-1273 nCoV Neutralizing antibodies observation observé omicron Omicron variant Participants platform provide reactogenicity Region SARS CoV-2 SARS-CoV-2 second dose Serious Adverse Event Serious Adverse Events Sputnik V Support titers vaccination Vaccine virus neutralizing titer virus neutralizing titers [DOI] 10.1016/j.xcrm.2022.100706 PMC 바로가기 [Article Type] Article
Protective antibodies and T cell responses to Omicron variant after the booster dose of BNT162b2 vaccineBNT162b2 백신의 추가 접종 후 오미크론 변이체에 대한 보호 항체 및 T 세포 반응Article Published on 2022-08-162022-09-11 Journal: Cell Reports Medicine [Category] SARS, 변종, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effects angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody antibody levels blocking antibodies BNT162b2 BNT162b2 vaccine booster dose cause CD4 CD8 coronavirus detectable domain dose dynamics of the immune response ENhance immune Immune escape immune response increase Interaction less longitudinal analysis majority memory mRNA mRNA vaccine Mutation of BNT162b2 omicron Omicron variant protective antibodies Protective antibody Protein RBD RBD-ACE2 receptor respiratory SARS-CoV-2 SARS-CoV-2 mRNA vaccine second dose serum severe acute respiratory syndrome Coronavirus Spike protein spike RBD-ACE2 inhibition. T cell T cell response T cell responses T cells vaccinated individual vaccinated individuals Vaccine variant variant spike wild-type [DOI] 10.1016/j.xcrm.2022.100716 PMC 바로가기 [Article Type] Article
Mobility was a significant determinant of reported COVID-19 incidence during the Omicron Surge in the most populous U.S. Counties이동성은 미국에서 가장 인구가 많은 카운티에서 Omicron Surge 동안 보고된 COVID-19 발병의 중요한 결정 요인이었습니다.Article Published on 2022-08-152022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval categories Cohort contrary Course covariates COVID-19 COVID-19 incidence cross-sectional analysis cumulative declined Epidemics exhibiting fatigue fraction Google Google mobility reports household size humans Immune escape incidence infect Infection intrinsic Mobility omicron Omicron variant peaked Perceived risk Principal component principal component analysis principal components question reported risk-mitigating behavior. robustness SARS-CoV-2 Significant susceptible individual susceptible individuals vaccination variant widespread [DOI] 10.1186/s12879-022-07666-y PMC 바로가기 [Article Type] Article
Management experience of a designated hospital for children with coronavirus disease 2019Article Published on 2022-08-152022-11-16 Journal: Zhongguo dang dai er ke za zhi = Chinese journal o [Category] SARS, 변종, [키워드] branch Child children children with COVID-19 China Chinese coronavirus disease Coronavirus disease 2019 COVID-19 Diagnosis discharge disease English global pandemic hospital hospital management hospitals Immune escape information management Medicine Mild moderate nosocomial omicron Omicron variant outbreak patients Pediatric case platform reduce Research risk School Shanghai significant increase South Transmissibility Treatment university Vaccine variant variants [DOI] 10.7499/j.issn.1008-8830.2206068 PMC 바로가기
Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern피부 패치 전달 소단위 백신은 우려되는 SARS-CoV-2 변이체에 대한 광범위 중화 항체 유도Article Published on 2022-08-122022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] booster circulation COVID-19 Delta demonstrated dominant Efficacy Health high-density highlight Immunity immunized induce mice Microarray Microarray patch Mutation neutralisation Neutralising Antibodies neutralising antibody omicron Omicron variant resulting robust SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant serum Spike protein subunit Subunit vaccine tested the spike protein Vaccine variant variants variants of concern Viral viral strain Viral variants [DOI] 10.1016/j.vaccine.2022.07.013 PMC 바로가기 [Article Type] Article
Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysisArticle Published on 2022-08-122022-11-15 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료기술, [키워드] 95% CI 95% confidence interval addition Admission admitted to ICU age Analysis average calculate calculated cohort study cohorts COVID-19 decrease delta variant dominant dropped ecological Ecological study groups hospital Hospital admissions Hospitalization Hospitalized ICU ICU admission ICU admissions increase in independent intensive care intrinsic Local omicron Omicron variant performed population-based cohort positive primary care proportion rate ratio reduced reduction reduction in required risk SARS-CoV-2 severity severity and vaccination status Severity of infection stratified substitution model. System Transmissibility vaccination variant [DOI] 10.3389/fpubh.2022.961030 PMC 바로가기
Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age5~11세 어린이의 오미크론에 대한 BNT162b2 백신의 효과Article Published on 2022-08-112022-10-30 Journal: The New England Journal of Medicine [Category] COVID-19, COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Analysis analyzed Antigen B.1.1.529 B.1.617.2 BNT162b2 children conducted coronavirus coronavirus disease Coronavirus disease 2019 dominant variant Effectiveness first dose Hospitalization incidence incidence rate of BNT162b2 omicron Omicron variant on children outcomes PCR assay PCR-confirmed Poisson regression polymerase predominant rate ratio reduced replaced reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections second dose severe acute respiratory syndrome Coronavirus Singapore Spread vaccination Vaccine variant was used Year [DOI] 10.1056/NEJMoa2203209 PMC 바로가기 [Article Type] Article
Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan오미크론 변종 대유행 중 코로나바이러스 질병 2019에 대한 3차 백신 접종의 효과: 일본의 전향적 관찰 연구Observational Study Published on 2022-08-102022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 임상, [키워드] 95% confidence interval administration booster dose caused Chain Reaction close contact contact with coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 vaccine dose doses Effectiveness enrolled evaluated highest Infection Japan mass vaccination mRNA Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples occurred omicron Omicron variant outbreak participant Participants polymerase chain reaction Prevent progressed progression prospective observational study receiving Ribonucleic acid RT-PCR RT-PCR test Swab test tested vaccination Vaccine vaccine dose variant were excluded with COVID-19 [DOI] 10.1038/s41598-022-17990-7 PMC 바로가기 [Article Type] Observational Study