SARS-CoV-2-specific CD4 + T cells are associated with long-term persistence of neutralizing antibodiesSARS-CoV-2-특이적 CD4 + T 세포는 중화 항체의 장기간 지속성과 관련이 있습니다Article Published on 2022-04-232022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] accompanied Alpha anti-N IgG anti-RBD antibody B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta CD4 Cluster Clusters Critical CXCL10 CXCL9 CXCR3 decay declined Delta disease onset Frequency Gamma highlight Humoral immunity Immune escape Lambda Ligand maintenance neutralized Neutralizing antibodies neutralizing antibody Neutralizing-antibody omicron Omicron variant P.1 persistence PROTECT protective immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants Significant significantly lower T cell T cells T-cell understanding vaccination Vaccine variant [DOI] 10.1038/s41392-022-00978-0 PMC 바로가기 [Article Type] Article
A randomized clinical trial of a booster dose with low versus standard dose of AZD1222 in adult after 2 doses of inactivated vaccines불활성화 백신 2회 투여 후 성인에서 AZD1222의 저용량 대 표준 용량의 추가 용량에 대한 무작위 임상 시험Randomized Controlled Trial Published on 2022-04-202022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI Adults anti-S anti-SARS-CoV-2 IgG anti-SARS-CoV-2 IgG. Anti-spike antibody Antibody titer ARMS AstraZeneca AZD1222 baseline booster booster dose ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine completion conducted CoronaVac CoronaVac vaccine delta variant dose double-blinded enrolled evaluate Fever geometric geometric mean geometric mean ratio Geometric means GMR GMRs healthy IgG immunogenicity inactivated Inactivated vaccine Infection IQR low dose low-dose median age median interval myalgia neutralization test neutralizing antibody Neutralizing antibody titer participant Prevent Randomized randomized clinical trial randomized, controlled trial RBD IgG reactogenicity receive recipient S-RBD SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly lower Standard dose surrogate surrogate virus neutralization test sVNT systemic reactogenicity the SARS-CoV-2 variant Viral Viral particles virus neutralization test wild type [DOI] 10.1016/j.vaccine.2022.03.036 PMC 바로가기 [Article Type] Randomized Controlled Trial
The effect of immunization with inactivated SARS-CoV-2 vaccine (CoronaVac) and/or SARS-CoV-2 infection on antibody levels, plasmablasts, long-lived-plasma-cells, and IFN-γ release by natural killer cells비활성화된 SARS-CoV-2 백신(CoronaVac) 및/또는 SARS-CoV-2 감염이 항체 수준, 형질모세포, 수명이 긴 형질 세포 및 자연 살해 세포에 의한 IFN-γ 방출에 미치는 영향Article Published on 2022-04-202022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] anti-S anti-SARS-CoV-2 spike protein anti-spike antibody antibody Antibody Response B cell CD138 CD19 CD27 Cell CoronaVac COVID-19 detectable dose Elecsy elicited ELISA kit evaluated flow cytometry four groups Germinal center group groups HCW HCWs healthcare worker Healthcare workers IAV IFN-gamma IFN-γ immunization inactivated Inactivated vaccine interferon gamma İstanbul Killer cell long-lived plasma cell long-lived plasma cells Lymph node lymph nodes median memory B cell memory B cells Migration natural infection natural killer natural killer cell no difference not differ patients percentage phenotype Plasma cells plasmablast plasmablasts qPCR RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine significantly higher significantly lower Spike protein study groups Test the antibody response the study group Turkey uninfected Vaccine Version virion was performed were measured Whole virion inactivated vaccine. [DOI] 10.1016/j.vaccine.2022.03.001 PMC 바로가기 [Article Type] Article
Impact of COVID-19 Pandemic on the Quality of Life of IBD PatientsObservational Study Published on 2022-04-192022-10-05 Journal: Medicina [Category] 임상, [키워드] Affect All the patient average bowel conducted COVID-19 COVID-19 pandemic diagnosed Diagnosis evaluated group Healthcare systems IBD Impact Inflammatory Inflammatory bowel disease life material medical service objective Patient Quality Quality of life recorded recruited Result significant difference significantly lower [DOI] 10.3390/medicina58050562 PMC 바로가기 [Article Type] Observational Study
Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort studyObservational Study Published on 2022-04-192022-10-04 Journal: CMAJ open [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality 95% CI 95% confidence interval acute COVID-19 adjusted Admission angiotensin receptor blocker ARB association average baseline characteristics changes in cohort study Community Comorbidity conducted COVID-19 pandemic death demographic characteristics Dexamethasone dysfunction examined excluded hospital Hospital admission IMPROVE in-hospital mortality Invasive mechanical ventilation less Logistic lower mortality management Mortality multicentre Observational cohort study Odds ratio organ support outcome outcomes pandemic Patient Pragmatic readmission Regression model remained renal dysfunction renal replacement therapy RRT severity of illness significantly lower therapy Vasopressor with COVID-19 [DOI] 10.9778/cmajo.20210216 PMC 바로가기 [Article Type] Observational Study
Differences in Humoral and Cellular Vaccine Responses to SARS-CoV-2 in Kidney and Liver Transplant Recipients신장 및 간 이식 환자의 SARS-CoV-2에 대한 체액 및 세포 백신 반응의 차이Article Published on 2022-04-142022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] adjust antibody Antibody Response Antigen blood sample cells coronavirus Coronaviruses COVID-19 difference elicit epitope Epitopes explained Generalized linear model groups IgG level IgG levels Immunosuppression kidney kidney transplant recipient kidney transplant recipients liver liver transplant mRNA Multiplex assay multivariable not affect nucleocapsid phenomenon quantified reactive recipient recipients remained response SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2 variants significantly lower significantly more Spike protein statistical significance T cell T cell response T cell responses T cells tested Transplant variant Wuhan strain [DOI] 10.3389/fimmu.2022.853682 PMC 바로가기 [Article Type] Article
Mortality rates among COVID-19 patients hospitalised during the first three waves of the epidemic in Milan, Italy: A prospective observational studyObservational Study Published on 2022-04-112022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] 95% CI 95% confidence interval adjusted Admission age association changed Comorbidity confounders COVID-19 COVID-19 patient Cox model Critical disease death disease severity First wave hazard ratio hospital hospitalisation hospitalised hospitalised COVID-19 patient Italy Mortality mortality rate no difference no significant difference obesity Patient presenting Probability prospective cohort study prospective observational study reduced risk risk risk of death second wave Sex significantly lower study period survival symptom onset the epidemic the Kaplan-Meier method the patient were used [DOI] 10.1371/journal.pone.0263548 PMC 바로가기 [Article Type] Observational Study
Peak IgG antibody titers against SARS-CoV-2 spike protein following immunization with the Pfizer/BioNTech BNT162b2 vaccine화이자/바이오엔텍 BNT162b2 백신 접종 후 SARS-CoV-2 스파이크 단백질에 대한 최고 IgG 항체 역가Article Published on 2022-04-082022-09-12 Journal: Fukushima journal of medical science [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Antibody titer blood sample BNT162b2 BNT162b2 vaccination BNT162b2 vaccine collected COVID-19 decrease female first vaccination Fukushima hospital IgG antibody IgG antibody against SARS-CoV-2 spike protein. IgG antibody titer immune response immunization investigated Japan male median age of BNT162b2 Older outcome participant peak peaked performed Pfizer/BioNTech SARS-CoV-2 spike protein second vaccination significantly lower statistical significance subsequent t-test vaccination [DOI] 10.5387/fms.2021-28 PMC 바로가기 [Article Type] Article
In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis [DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article
Impact of Therapy in Patients with Hematologic Malignancies on Seroconversion Rates After SARS-CoV-2 VaccinationSARS-CoV-2 예방접종 후 혈액암 환자의 혈청전환율에 대한 치료의 영향Meta-Analysis Published on 2022-04-052022-09-12 Journal: The oncologist [Category] COVID19(2023년), SARS, 진단, [키워드] 95% confidence interval acute respiratory syndrome Anti-CD20 antibody antibody ARMS article chronic CLL CLL patient conducted Control coronavirus COVID-19 database determinants Efficacy first dose group healthy control hematologic Hematologic malignancy hematological Hematological malignancies Hematological malignancy Impact kinase literature review malignancies Meta-analysis organization Patient patient population patients treated Rate remained review risk SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine second dose seroconversion rate significant difference significantly lower subject subjects the antibody response treated vaccination Vaccine [DOI] 10.1093/oncolo/oyac032 PMC 바로가기 [Article Type] Meta-Analysis