Sequence Analysis and Structure Prediction of SARS-CoV-2 Accessory Proteins 9b and ORF14: Evolutionary Analysis Indicates Close Relatedness to Bat CoronavirusResearch Article Published on 2020-10-202022-10-27 Journal: BioMed Research International [Category] COVID-19, [키워드] absence Accessory accessory protein accessory proteins acute respiratory syndrome Affect amino acid sequence Analysis bat Complete contribute coronavirus drug design eight ENCODE estimate experimental structure expresse functional Genome highly active Host human SARS-CoV-2 indicate infect Local modeling Open reading frame ORFs Pathogenesis Phylogeny prediction promote Protein Proteins residue RNA genome SARS-CoV-2 single-stranded stability Structure structures targets Tunnel Vaccine virulence virus virus replication whole-genome [DOI] 10.1155/2020/7234961 PMC 바로가기 [Article Type] Research Article
Sequence Analysis and Structure Prediction of SARS-CoV-2 Accessory Proteins 9b and ORF14: Evolutionary Analysis Indicates Close Relatedness to Bat CoronavirusResearch Article Published on 2020-10-202022-10-27 Journal: BioMed Research International [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] absence Accessory accessory protein accessory proteins acute respiratory syndrome Affect amino acid sequence Analysis bat Complete contribute coronavirus drug design eight ENCODE estimate experimental structure expresse functional Genome highly active Host human SARS-CoV-2 indicate infect Local modeling Open reading frame ORFs Pathogenesis Phylogeny prediction promote Protein Proteins residue RNA genome SARS-CoV-2 single-stranded stability Structure structures targets Tunnel Vaccine virulence virus virus replication whole-genome [DOI] 10.1155/2020/7234961 PMC 바로가기 [Article Type] Research Article
The neurological manifestations of COVID-19 – A case seriesOriginal Article Published on 2020-10-172022-10-29 Journal: Journal of Clinical and Translational Research [Category] COVID-19, [키워드] acute respiratory syndrome case sery cause caused clinician Community coronavirus coronavirus disease Course CoV COVID-19 diagnose epilepsy Features General population help hospital infective information involved neurological invasion neurological manifestation Neurological symptoms neurological system outbreak over Patient patients patients with COVID-19 Pneumonia presenting presenting symptom Relevance reported Respiratory illness SARS-CoV Seizure Seizures shown structures virus PMC 바로가기 [Article Type] Original Article
Modeling between-population variation in COVID-19 dynamics in Hubei, Lombardy, and New York City530 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age Comorbidities consequence Contact coronavirus COVID-19 COVID-19 pandemic curtail death deaths develop distribution distributions Factor group groups highlight Infection Intervention lombardy mitigate modeling National New York City nonpharmaceutical intervention parameters physical distancing physical distancing measure populations progression reduce reported reveal SARS-CoV-2 SARS-CoV-2 transmission Significance structures subsequent the epidemic Transmission Transmission dynamics United States Variation [DOI] 10.1073/pnas.2010651117 PMC 바로가기 [Article Type] 530
Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of RecognitionReview Published on 2020-10-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] caused coronavirus Coronaviruses CoV COVID-19 pandemic CoVs death detectable Epidemic Fatality rate H1N1 HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 host range host receptor human CoVs humans IAV IBV immunologically Infection infections Influenza influenza A virus influenza B Influenza virus influenza viruses knowledge Lineage mild respiratory naïve outbreak pandemic protein receptors Receptor binding receptors Recognition recorded sialyl glycans specificity spike glycoproteins spikes structures Subtypes variants virus virus variants viruses zoonotic [DOI] 10.3390/vaccines8040587 PMC 바로가기 [Article Type] Review
Predictors of Severity in Covid-19 Patients in Casablanca, MoroccoInfectious Disease Published on 2020-09-292022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 95% confidence interval Acute kidney injury acute respiratory distress acute respiratory syndrome affected ARDS C-reactive protein chest scan Cluster Clusters Comorbidities Comorbidity Coronary heart disease coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 severity Critical case CRP D-dimer described diabete died disease severity dry cough Dyspnea eight epidemiological Factor ferritin Fever form Genetic studies hospital Hospital admission Hydroxychloroquine hypertension ICU ICU patient ICU Patients illness onset infected patient Infection intensive care interquartile range IQR laboratory data lactate dehydrogenase logistic regression model lymphopenia male median age median time men Mild moderate Morocco multivariable logistic regression non-severe patient North Odds ratio Older Older age outcome oxygen saturation pandemic Patient patients patients with comorbidities predict Predictive Predictive Factors reported Reporting required Result retrospective risk factor SARS-CoV-2 SARS-COV-2 infection separated Seven severe COVID-19 Severe patient severity single-center structures syndrome System Thromboembolic event Tocilizumab transferred univariable univariable analysis university were infected [DOI] 10.7759/cureus.10716 PMC 바로가기 [Article Type] Infectious Disease
COVID-19: instruments for the allocation of mechanical ventilators—a narrative reviewReview Published on 2020-09-292022-11-01 Journal: Critical Care [Category] COVID-19, SARS, [키워드] COVID-19 COVID-19 pandemic criteria Decision making element Ethics Evidence Health Health care rationing help identify measure mechanical ventilator mechanical ventilators pandemic Pandemics professional protocol protocols question Spread structures Support the disease World Health Organization [DOI] 10.1186/s13054-020-03298-3 PMC 바로가기 [Article Type] Review
Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and LimitationsReview Published on 2020-09-282022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory syndrome boost caused Compound coronavirus Coronavirus disease 2019 Coronavirus-2 CoV COVID-19 CoVs current drug effective feature Host immune response immune system inhibitor limitation MERS-CoV Middle East Mutation outbreak papain-like proteases Perspective PLPro Prevent protease SARS-CoV SARS-CoV-2 structures Support suppress syndrome targets the patient viral genome viral replication [DOI] 10.3390/ph13100277 PMC 바로가기 [Article Type] Review
The efficiency in the ordinary hospital bed management in Italy: An in-depth analysis of intensive care unit in the areas affected by COVID-19 before the outbreakResearch Article Published on 2020-09-222022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] affected Analysis country COVID-19 Critical determine diffusion Efficiency Health health system hospital Hospital wards Hospitalization ICU ICUs in-depth analysis intensive care intensive care unit Italian Italian region Italy majority management occurred outbreak Patient question reduction regions Respiratory disease resulting risk robust structures treat treated [DOI] 10.1371/journal.pone.0239249 PMC 바로가기 [Article Type] Research Article
COVID-19 mortality dynamics: The future modelled as a (mixture of) past(s)Research Article Published on 2020-09-112022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] applied approach can be used comparison competing country COVID-19 COVID-19 epidemic COVID-19 mortality data-driven death Europe European country Factor health system impacted include Mild Mortality structures trajectory [DOI] 10.1371/journal.pone.0238410 PMC 바로가기 [Article Type] Research Article