Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation네 가지 COVID-19 파동에 걸친 어린이의 SARS-CoV-2 변이체의 역학 특성 및 임상 발현과의 상관 관계Article Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] B.1.1.7 children circulation clade clades correlation COVID-19 defined demonstrated feature Frequency highest Hospitalization Lineage lineages Local manifestation negative correlation pandemic SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 pandemic SARS-CoV-2 positive patient SARS-CoV-2 transmission SARS-CoV-2 variant severity sustained Transmission Viral load Virological [DOI] 10.1038/s41598-022-14426-0 PMC 바로가기 [Article Type] Article
Performance differences among commercially available antigen rapid tests for COVID-19 in BrazilArticle Published on 2022-06-162022-11-16 Journal: PLoS ONE [Category] 치료기술, [키워드] affected Ag-RDT Antigen antigen detection Brazil Clinical management community transmission coronavirus disease COVID-19 cycle threshold diagnose Diagnosis diagnosis of COVID-19 eight ENhance evaluate evaluated greater hospital Hospital admission Lower mild COVID-19 symptom moderate pandemic Patient performance performed presenting protocol ranged Rapid test recommendation reducing reduction risk factor RT-PCR RT-qPCR sensitivity severe disease specificity the disease Viral load virus [DOI] 10.1371/journal.pone.0269997 PMC 바로가기
Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다Clinical Trial Published on 2022-06-152022-09-11 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI absence Adaptive immunity adjusted hazard ratio adverse events affected antibody Antibody Response clearance Clinical research Comorbidity Comprehensive conducted convalescent plasma Convalescent plasma therapy Corona COVID-19 Critical demonstrated disease status Efficacy evidenced faster hazard ratio hospitalized COVID-19 patient human infection human infections Immunotherapy individual Innovation Intervention IQR Kaplan-Meier analysis laboratory parameter median interval Mortality neutralization Neutralizing neutralizing antibody onset of symptom parameter Phase I plasma plasma therapy pool principle priority Program promote recipient recipients Red respond Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 clearance SARS-CoV-2 vaccines serological significantly survival therapeutic Therapeutics therapy transfusion-related adverse event transfusion-related adverse events Trial university University of Zurich Viral viral clearance Viral load Viremia Virological virus clearance [DOI] 10.1172/JCI158190 PMC 바로가기 [Article Type] Clinical Trial
Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes중환자 COVID-19 환자의 폐실에서 SARS-CoV-2 바이러스 부하가 바이러스 혈청 부하 및 치명적인 결과와 상관관계Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] association BAL Blood bronchoalveolar Bronchoalveolar lavage clinical Clinical data Clinical outcome clinical outcomes compartment contribute copy number correlation COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical care Critically ill Critically ill patient critically ill patients Croatia diagnostic disease elevated highest hospital ICU admission Ill intensive care intensive care unit load Lower respiratory tract lung Lungs mechanical ventilation support outcome outcomes pandemic parameter Predictive Prognostic value pulmonary qPCR quantification quantified SARS-CoV-2 SARS-CoV-2 detection serum sample serum samples sputum survival Swab swabs upper respiratory tract Viral load viral load analysis viral loads Virus quantification virus titers while [DOI] 10.3390/v14061292 PMC 바로가기 [Article Type] Article
Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In VitroSARS-CoV-2 감염의 광역학적 비활성화 및 시험관 내 항바이러스 치료 효과Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antiviral Antiviral agents approach Cell cell cultures cell viability Concentration coronavirus Coronavirus-2 COVID-19 Critical Culture current death detectable Effect heat-inactivated in vivo inactivation Infection infectiousness Infectivity log measure Microscopy mitochondrial Mutation near-infrared light pandemic Pathogens PDI photodynamic inactivation photodynamic therapy photosensitizer Potential treatment qPCR reduce reduced reduction required SARS SARS-CoV-2 SARS-CoV-2 isolate severe acute respiratory syndrome Coronavirus severe disease significantly THPTS Toxicity Treatment uninfected Vaccines variety Vero Cell viability viral cytopathic effect viral infection viral infections Viral load Viral RNA virion virus virus load virus suspension viruses were assessed [DOI] 10.3390/v14061301 PMC 바로가기 [Article Type] Article
Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters프로테오솜 보조제가 첨가된 SARS-CoV-2 스파이크 단백질 기반 백신을 사용한 비강내 면역은 마우스와 햄스터에서 면역원성과 효능이 있습니다.Article Published on 2022-06-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] addition Antigen B.1.351 B.1.617.2 Beta binding Blood body weight Body weight loss cellular Delta disease evaluated Formulation hamster help IgA titers IgG immune responses immunization immunogenic intranasal Lungs mice mucosal mucosal surface Neutralizing activity offer pandemic persistence prefusion Prevent profile protective immune response Protein protein subunit vaccine reduce reducing reference strain resistin robust SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 vaccine serum antibodies serum antibody spike Spike protein Subunit vaccine the SARS-CoV-2 Vaccine variants variants of concern Viral viral entry Viral load viral spike protein weight loss [DOI] 10.1038/s41598-022-13819-5 PMC 바로가기 [Article Type] Article
Diabetes enhances viral loads in COVID-19 Research Highlights Published on 2022-06-102022-10-05 Journal: Nature reviews. Immunology [Category] COVID19(2023년), SARS, 치료법, [키워드] COVID-19 ENhance Viral load [DOI] 10.1038/s41577-022-00748-7 [Article Type] Research Highlights
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse파이로나리딘은 마우스의 SARS-CoV-2 감염으로부터 보호합니다Article Published on 2022-06-102022-09-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Antiviral antiviral activity antiviral drug antiviral drugs approved assist Cell cells chemokine coronavirus COVID-19 demonstrated Ebola Efficacy evaluated in vitro in vivo infiltration inhibit SARS-CoV-2 inhibited involved K18-hACE lung Lung pathology Lungs M pro mice molecular mechanism mouse pro-inflammatory pro-inflammatory cytokines pyronaridine reducing reduction in Remdesivir Replication respiratory Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory coronavirus Spike protein statistically significant reduction structure activity relationship the SARS-CoV-2 therapeutic Transgenic mouse Treatment Viral Viral load [DOI] 10.1021/acsinfecdis.2c00091 PMC 바로가기 [Article Type] Article
Herpesvirus and neurological manifestations in patients with severe coronavirus disease중증 코로나바이러스 질환 환자의 헤르페스바이러스 및 신경학적 징후Article Published on 2022-06-082022-09-11 Journal: Virology Journal [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed association Central nervous system Chain Reaction change clinical manifestation Coinfection coronavirus coronavirus disease COVID-19 cytomegalovirus demonstrated diagnosed with COVID-19 evaluated herpes herpes simplex herpes simplex virus Herpes Simplex Virus 1 herpesvirus HHV-6 highest Infection Manifestations neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms outcome outcomes Patient patients patients with COVID-19 polymerase chain polymerase chain reaction Prevalence qPCR quantified Quantitative quantitative polymerase chain reaction SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease statistically significant Viral load viral loads virus [DOI] 10.1186/s12985-022-01828-9 PMC 바로가기 [Article Type] Article