Intravenous administration of BCG protects mice against lethal SARS-CoV-2 challengeBCG의 정맥 투여는 치명적인 SARS-CoV-2 공격으로부터 마우스를 보호합니다Brief Definitive Report Published on 2022-02-072022-09-10 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] addition Administered alteration Analysis bacille Calmette-Guérin BCG BCG vaccination Cell cellular compartment clinically COVID-19 cytokine cytokine production Host immunopathology increase in Inflammatory inflammatory cell innate response intravenous Intravenous administration long-lasting mechanism mice Multivariate analysis myeloid cell nonspecific Pathogens pediatric phenomenon promote PROTECT provide pulmonary immune response recruitment reduced viral load reduced viral loads reducing reductions reductions in reported SARS-CoV-2 SARS-COV-2 infection subcutaneous route tissue pathology transgenic mice Tuberculosis vaccination variant Viral Viral load virus while [DOI] 10.1084/jem.20211862 PMC 바로가기 [Article Type] Brief Definitive Report
An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case ReportCase report Published on 2022-02-042022-10-05 Journal: Chest [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute exacerbation adverse event association BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine Case report characterized clinically Course COVID-19 COVID-19 vaccination disease Exacerbation Glucocorticoids idiopathic Idiopathic pulmonary fibrosis immunization Infection Interstitial lung disease IPF Lung disease morbidity and mortality proportion pulmonary raise report scar tissue Toxicity treated vulnerable patient while [DOI] 10.1016/j.chest.2021.07.2160 [Article Type] Case report
The oxygenation module: the missing link in using sleep apnea devices to treat COVID-19 pneumonia at homeResearch Published on 2022-02-042022-10-28 Journal: BioMedical Engineering OnLine [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] airways Care clinical clinical testing clinically components Concentration COVID-19 COVID-19 patient COVID-19 pneumonia patient COVID-19 positive patients CPAP Critical Critical care early stage equipment healthcare homecare include intensive care units limitation mechanisms NIV Non-invasive non-invasive ventilation oxygen oxygen supplementation oxygen supply Oxygenation PaO patients patients treated Pneumonia positive airway pressure reducing Result sleep apnea Test test result treat Treatment [DOI] 10.1186/s12938-022-00982-z PMC 바로가기 [Article Type] Research
Development and multi-center clinical trials of an up-converting phosphor technology-based point-of-care (UPT-POCT) assay for rapid COVID-19 diagnosis and prediction of protective effects신속한 CovID-19 진단 및 보호 효과의 예측을위한 UPT-POCT (Up-Converting Phosphor Technology-CARE) 분석의 개발 및 다중 센터 임상 시험Clinical Trial Published on 2022-02-032022-09-01 Journal: BMC Microbiology [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] Accuracy antibody Chain Reaction China clinical trial clinically Concentration correlation COVID-19 COVID-19 cases COVID-19 diagnosis COVID-19 patient COVID-19 patients Critical cross-reaction cross-reactions Cutoff defined development ELISA evaluated healthy hospital inactivated indicated intensity lateral flow lateral flow strip microneutralization Microneutralization assay NAb titer NAb titers Neutralizing activity neutralizing antibody OD value OD values Patient performed POCT point-of-care Polymerase chain reaction test positive protective effect Protective effects quantitation Quantitative RBD RBD-specific antibodies RBD-specific antibody RBD-specific total antibodies Reactions Receptor-binding domain recovered patient recovered patients Result reveal reverse transcriptase SARS-CoV-2 SARS-CoV-2 spike protein Sensitivity and specificity serum sample serum samples Seven significantly specific antibodies Spike protein supplementary material test results the antibody the receptor-binding domain total antibodies total antibody Up-conversion phosphor technology vaccinee vaccinees viruses was determined [DOI] 10.1186/s12866-022-02450-z PMC 바로가기 [Article Type] Clinical Trial
Cardiac Arrest and Hypoxic-Ischemic Encephalopathy Following an Emergency Caesarean Section in a COVID-19 PatientObstetrics/Gynecology Published on 2022-02-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Admission arrest bradycardia cardiac cardiorespiratory arrest catastrophic chest pain circulation clinically Coma Complication consequence coronavirus coronavirus disease coronavirus in pregnancy COVID-19 COVID-19 in pregnancy COVID-19 infection COVID-19 vaccination death discharged home distress Dyspnea Emergency Encephalopathy expired fetal gravid Health healthy individual highlight Hospitalized hypoxic Infection medical condition much higher nine Patient Pneumonia positive prenatal remained required Respiratory failure risk sar-cov-2 infection SARS-CoV-2 sars-cov-2 during pregnancy Section severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suffered supplemental oxygen the patient virus was performed while worsening [DOI] 10.7759/cureus.21867 PMC 바로가기 [Article Type] Obstetrics/Gynecology
CRISPR Approaches for the Diagnosis of Human DiseasesReview Published on 2022-02-032022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] approach Cas13 clinically comparable COVID-19 test CRISPR detect diagnostic DNA and RNA gold standard Human human diseases Laboratory Molecular biology Mutation mutations Nucleic acid detection offer pathogen platform reproducibility sensitivity specificity subtype [DOI] 10.3390/ijms23031757 PMC 바로가기 [Article Type] Review
Effective deep learning approaches for predicting COVID-19 outcomes from chest computed tomography volumes흉부 컴퓨터 단층 촬영 부피에서 Covid-19 결과를 예측하기위한 효과적인 딥 러닝 접근Article Published on 2022-02-022022-09-01 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] aggregate Algorithm approach artificial intelligence AUC automated Chest computed tomography Chest CT Clinical data clinically Combination Computed tomography Computer science coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 patients COVID-19 pneumonia COVID-19 prognosis deep learning develop effective Evolution feature healthy IMPROVE joint lung Metadata Mortality Novel coronavirus novel coronavirus disease Numerous other viral pneumonia outcome pandemic participant Pneumonia predict problems Prognosis pulmonary lesion pulmonary lesions reduce risk stratification Transmission viral infection Viral pneumonia Volume volumetric [DOI] 10.1038/s41598-022-05532-0 PMC 바로가기 [Article Type] Article
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samplesResearch article Published on 2022-02-022022-10-05 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 변종, [키워드] Anticoagulant Anticoagulants anticoagulation aptamer bind clinically cofactor collected coronavirus disease COVID-19 COVID-19 patient disrupt factor V/Va feasibility Generation Hemostasis inhibitor Interaction interactions lack low molecular weight mechanism membranes nanomolar affinity Patient plasma protamine Protein protein inhibitor protein-membrane interaction regulate reveal reversed RNA synergy target therapeutic thrombosis Whole blood [DOI] 10.1016/j.chembiol.2022.01.009 [Article Type] Research article
From Free Binding Energy Calculations of SARS-CoV-2—Receptor Interactions to Cellular Immune ResponsesSARS-CoV-2의 자유 결합 에너지 계산 - 수용체 상호 작용에서 세포 면역 반응까지Brief Report Published on 2022-02-022022-09-10 Journal: Medicina [Category] COVID19(2023년), MERS, SARS, 변종, [키워드] angiotensin angiotensin converting enzyme Antigen assumed binding calculation change clinically computational analysis Computational biology danger signal danger signals disease severity energy enzyme expected Free free energy Free energy calculation Free energy calculations hACE2 HLA type Host human angiotensin converting enzyme 2 human leukocyte antigen immune responses infected cell Infection inflammatory immune responses Interaction leukocyte Lower respiratory tract molecular Occurrence omicron partial immunity pathogenicity Positive selection predicted produced RBM receptor Receptor binding Receptor binding domain receptor interaction reduced required respiratory response resulting SARS-CoV-2 SARS-CoV-2 Omicron SARS-CoV-2 spike protein Spike protein trade-off Transmissibility upper respiratory tract Vaccinations variants variants of concern virus viruses VOCs wild type [DOI] 10.3390/medicina58020226 PMC 바로가기 [Article Type] Brief Report
Use of remdesivir in patients with COVID-19: a systematic review and meta-analysisCOVID-19 환자의 렘데시비르 사용: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-022022-09-11 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI adverse event adverse events Clinical improvement clinical trials clinically control group control groups controls COVID-19 COVID-19 patient eligibility criteria English Evidence extracorporeal membrane oxygenation had no mechanical ventilation membrane Meta-analysis moderate moderate to severe Mortality no significant difference no significant differences Observational cohort study outcomes Oxygenation pacientes com COVID-19 pacientes hospitalizado Patient patients hospitalized patients with moderate Phase 3 question randomizado randomized clinical trial RCT RCTs receiving Remdesivir retrieved risk risk difference selected severe COVID-19 shown statistically significant difference systematic review treat Treatment [DOI] 10.36416/1806-3756/e20210393 PMC 바로가기 [Article Type] Meta-Analysis