hACE2
[대역어] HACE2
[용어속성] Enzyme
[용어속성] Enzyme
De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2
Research Paper
[키워드] ACE2
Analysis
angiotensin-converting enzyme 2
antiviral drug
antiviral therapeutic
approach
association
binding
binding affinity
can be used
COVID-19
COVID-19 disease
Critical
effective
exhibited
experiment
global pandemic
glycine
hACE2
hACE2 protein
human ACE2
human cell
human cells
impacted
inhibit
initiate
interactions
linker
motif
outbreak
peptide
peptides
Protein
protocol
RBD
receptor
Receptor binding domain
SARS-CoV-2
sequence
significantly
Spike protein
stability
the SARS-CoV-2
treat
virus
wild-type
wild-type hACE2
[DOI] 10.18632/aging.103416 PMC 바로가기 [Article Type] Research Paper
[DOI] 10.18632/aging.103416 PMC 바로가기 [Article Type] Research Paper
Genetic variability of human angiotensin‐converting enzyme 2 (hACE2) among various ethnic populations
Original Article
[키워드] absence
ACE gene
ACE2
Affect
allele frequency
angiotensin
angiotensin‐converting enzyme 2
appear
Asian
Asians
binding
binding free energy
calculated
Caucasians
cellular entry
changes in
Characteristics
Chinese
clinical impact
COVID‐19
COVID‐19
death
demonstrated
eight
enzyme
ethnic variation
European
examined
explain
expression
expression level
Factor
functional
Gene Expression
Generalizability
genetic difference
Genetic polymorphism
genetics
hACE2
hACE2 receptor
human populations
implication
in vitro
Infection
infections
influence
magnitude
minor allele frequency
Missense mutation
Molecular dynamics simulation
Mortality
mutant
Mutation
Numerous
paucity of data
performed
polymorphism
Population
Potential treatment
Protein
receptor
Result
S protein
SARS‐CoV‐2
SARS‐CoV‐2
severity
susceptibility
target
Variability
variant
Variation
virus
[DOI] 10.1002/mgg3.1344 PMC 바로가기 [Article Type] Original Article
[DOI] 10.1002/mgg3.1344 PMC 바로가기 [Article Type] Original Article
Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding domain
Research Article
[키워드] ACE2
Amino acid
antiviral peptides
antiviral properties
approach
approaches
binding
binding energy
bioinformatics
caused
chimeric
COVID-19
COVID-19 pandemic
criteria
Critical
database
domain
drug
effective
experimental validation
Final
FIVE
hACE2
Infection
inhibit
interact
investigated
Medicine
meet
nCoV
nCoV-19
peptide
Peptide design
physiochemical properties
Potential
Prevent
residue
residues
restrict
SARS-CoV-2
second
selected
Seven
spike
Spike protein
spike receptor-binding domain
the SARS-CoV-2
Vaccine
virus
[DOI] 10.12688/f1000research.24074.1 PMC 바로가기 [Article Type] Research Article
[DOI] 10.12688/f1000research.24074.1 PMC 바로가기 [Article Type] Research Article
Cell entry mechanisms of SARS-CoV-2
530
[키워드] ACE2 receptor
activated
Activation
acute respiratory syndrome
bind
binding affinity
biochemical
Cell
cell entry
cells
comparable
contribute
coronavirus
coronavirus disease
COVID-19
domain
Entry mechanism
entry receptor
feature
furin
hACE2
hidden
highlighting
human ACE2
human cell
immune
immune evasion
Intervention
investigated
less
maintain
mechanism
mechanisms
pandemic
proprotein convertase furin
protease
Proteases
provide
pseudovirus entry assay
pseudovirus entry assays
RBD
receptor
Receptor binding
reducing
SARS-CoV
SARS-CoV RBD
SARS-CoV-2
SARS-CoV-2 entry
SARS-CoV-2 RBD
SARS-CoV-2 spike
second
Significance
Spike protein
Spread
Surveillance
the RBD
understanding
virus
[DOI] 10.1073/pnas.2003138117 PMC 바로가기 [Article Type] 530
[DOI] 10.1073/pnas.2003138117 PMC 바로가기 [Article Type] 530
Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation
Article
[키워드] acute respiratory syndrome
Antiviral
antiviral agent
Antiviral agents
binding domain
carried
component
Corona virus
coronavirus
COVID-19
COVID-19 symptoms
docking
docking score
enzyme
Essential
essential oil
essential oils
hACE2
investigation
Ligand
M pro
molecular docking
molecular docking analysis
normalized
Oil
pathogenic viruses
Potential
Protein
Protein target
RNA-dependent RNA polymerase
SARS-CoV-2
SARS-CoV-2 main protease
SARS-CoV-2 RdRp
shown
Spike protein
target
targets
the SARS-CoV-2
unlikely
virus
[DOI] 10.3390/ijms21103426 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms21103426 PMC 바로가기 [Article Type] Article
SARS‐CoV‐2, an evolutionary perspective of interaction with human ACE2 reveals undiscovered amino acids necessary for complex stability
Original Article
[키워드] ACE2
Amino acid
Analysis
Betacoronavirus
betacoronavirus spike protein
binding
cell receptor
complex
conserved
coronavirus
Critical
death
determine
directional
effective
ENhance
evolutionary dynamics
Factor
FIVE
genomic region
glycine
hACE2
host cells
human ACE2
human cell
human cells
human host
implicated
IMPROVE
infect
Infection
infections
inhibiting binding
Interaction
modeling
molecular dynamics
performed
Perspective
Positive selection
predict
purifying selection
receptor
receptor ACE2
receptor‐binding domain
residue
reveal
Salt Bridge
SARS‐CoV‐2
SARS‐CoV‐2
selection pressure
spike glycoprotein
Spike protein
stability
viral evolution
viral lineages
viral spike protein
virus
[DOI] 10.1111/eva.12980 PMC 바로가기 [Article Type] Original Article
[DOI] 10.1111/eva.12980 PMC 바로가기 [Article Type] Original Article
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
Article
[키워드] antibodies
antibody
beta coronavirus
biology of SARS-CoV-2
cathepsin L
caused
Cell
characterization
CoV
COVID-19
Critical
cross-neutralization
cross-neutralization activity
cross-reactivity
drug
entry pathway
enzyme
hACE2
immune
Infection
inhibit
less
MERS-CoV in 2012
Outbreaks
PROTECT
pseudovirions
pseudovirus
receptor
SARS virus
SARS-CoV
SARS-CoV S
SARS-CoV-2
SARS-CoV-2 S
SARS-CoV-2 S protein
sera
spike glycoprotein
Spike protein
Spread
T62
target
the SARS-CoV-2
Vaccine
viral infection
virus entry
Virus-host interactions
zoonotic
[DOI] 10.1038/s41467-020-15562-9 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/s41467-020-15562-9 PMC 바로가기 [Article Type] Article
SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium
Article
[키워드] addition
airway
airway epithelial cells
airway epithelium
Antisera
apical surface
Atypical
Calu-3
Calu-3 cell
Cell
cells
cellular
Characteristics
ciliated
ciliated cell
consequence
coronavirus
coronavirus pathogenesis
Coronavirus replication
Culture
cultures
detected
develop
did not reduce
dry cough
efficient
enzyme
Epidemics
epithelial
epithelial cell
epithelial cell line
Experimental result
feature
Fever
fluorescent
Frame
GFP
hACE2
HAE
Human
human airway epithelia
human airway epithelial
Human airway epithelium
human lung
human pathogen
in vitro
in vitro model
in vivo
Infection
inoculated
insertion
late stage
log
Lower respiratory tract
lung
lung epithelial
mechanism
Morphological
new strain
onset of symptoms
ORF
Pathogenesis
pathology
physiological
Pneumonia
Post-infection
primary cell
progeny virion
Protein
provide
reached
receptor
reduced
replicate
replicated
Replication
reported
reservoir
respiratory virus
resulting
SARS Coronavirus
SARS-CoV
SARS-CoV GFP
SARS-CoV infection
Support
susceptible
target
tight junction
Trachea
Vero E6
viral infection
viral replication
viral titer
virus
wild type
zoonotic
[DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.virusres.2007.03.013 PMC 바로가기 [Article Type] Article