Anti-cancer therapy and clinical trial considerations for gynecologic oncology patients during the COVID-19 pandemic crisisShort communication Published on 2020-07-012022-10-05 Journal: Gynecologic oncology [Category] 임상, [키워드] addition alteration Cancer Care Chemotherapy clinical trial clinical trials co-morbidities Consensus Contact COVID 19 COVID-19 COVID-19 pandemic develop deviation effort Factor Health high risk immunosuppressive impacted initial IRB less limit morbidity Mortality objective occur Older oncology patient pandemic Patient patient safety recommendation regimen Regulatory resource resources Result risk Society Sponsor therapy Treatment Trial [DOI] 10.1016/j.ygyno.2020.04.694 [Article Type] Short communication
COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?Case report Published on 2020-07-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] SARS, 유전자 메커니즘, [키워드] B cell B-cell Clinical deterioration Complete Complication coronavirus disease 19 COVID-19 COVID-19 affected patients death depleting discharged disease disease entity Elderly patient Follow-up high risk higher risk Hospitalization Hypothesis immune response Immunosuppressant Immunosuppression immunosuppressive infected patient monoclonal antibody multiple sclerosis occurred overactive Patient patient symptom patients with comorbidity Potential treatment Protective Result Support Symptom tested therapy treated [DOI] 10.1016/j.msard.2020.102120 [Article Type] Case report
Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 OutbreakArticle Published on 2020-06-262022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] adherent age Campania clinical clinical factor clinical impact clinical information Colitis condition coronavirus Corticosteroid COVID-19 COVID-19 infection diagnosed with COVID-19 disease EGID (Eosinophilic gastrointestinal disease) Eosinophilic eosinophilic esophagitis eosinophils esophagitis females gastroenteritis Gastrointestinal gastrointestinal disease Gender Immunosuppression immunosuppressive Impact Infection lockdown measure Most patient nine Occurrence organized Patient patients preventive measure Psychological psychological Impact Quality of life risk SARS-CoV-2 SARS-COV-2 infection Sex steroid study population susceptible the SARS-CoV-2 therapy university Veneto web-based study were recorded [DOI] 10.3390/jcm9062011 PMC 바로가기 [Article Type] Article
The Dilemma of Renal Involvement in COVID-19: A Systematic ReviewInternal Medicine Published on 2020-06-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute kidney acute kidney insufficiency acute respiratory syndrome advanced age affected article Chronic kidney disease Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 positive patients Cytokine release syndrome dialysis dilemma Health healthcare immunosuppressive intensive care units Involvement Kidney disease mortality rate outcome Particular Pathogenesis Patient patients patients died Prevalence recipients renal renal replacement therapy resource review SARS-CoV-2 severe disease course Spread subset therapy [DOI] 10.7759/cureus.8632 PMC 바로가기 [Article Type] Internal Medicine
A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-06-032022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 age analogue anticipated assigned Asymptomatic blinded bpm Characteristics clinical trial comparator components Contact Controlled trial coronavirus disease COVID-19 COVID-19 symptom COVID19 Date deficiency develop Diabetes Mellitus Diagnosis disease dissemination dose double-blind drug Efficacy Efficiency eight element enrolled enrolment EU Clinical Trial evaluate evaluate the effect exclusion criteria experimental arm female participant Final Glucose haloperidol healthcare healthcare worker Healthcare workers hematological Hemodialysis hepatitis B Hereditary high risk history HIV HIV infection hospital hypersensitivity IgM/IgG immune immunosuppressive incidence Inclusion Infection Inflammatory cytokine Intervention less lymphopenia male melatonin men and women multicenter myasthenia gravis number objective outcome participant Patient PCR Placebo polymerase chain post-symptom onset Premenopausal Prevent prophylactic treatment Prophylaxis protocol Ramón randomisation randomised randomised controlled trial randomization Randomized Rapid test receiving recruited renal failure Research Retinitis rheumatoid arthritis risk RT-PCR Sample size SARS-CoV 2 SARS-CoV-2 SARS-COV-2 infection SAS version 9.4 secondary sequence Seroconversion severe COVID-19 severity of COVID-19 Sex Spain Spanish statistical status stratified study drug Study protocol symptomatic infection symptomatic SARS-CoV-2 infection Treatment Trial two-arm parallel ulcerative colitis understanding urinary pregnancy test Vasculitis website weight women [DOI] 10.1186/s13063-020-04436-6 PMC 바로가기 [Article Type] Letter
Head and neck oncology during the COVID-19 pandemic: Reconsidering traditional treatment paradigms in light of new surgical and other multilevel risksReview article Published on 2020-06-012022-10-05 Journal: Oral oncology [Category] SARS, 치료법, [키워드] adverse outcomes aerosol generating procedure anticipated Cancer Care Cell COVID-19 COVID-19 infection COVID-19 pandemic deficiency favor Guidance HCW HCWs head head and neck cancer Head and neck oncology Health Health care worker immunosuppressive indicated management mucosal Mucosal squamous cell carcinoma Multilevel risk nosocomial COVID-19 novel Occurrence oncology operative Outbreaks Patient patients Personal protective equipment PPE protocol resource risk risk stratification Safe SARS-CoV-2 surgical Surgical barriers Surgical risk the patient therapy Traditional Transmission Treatment Treatment paradigms [DOI] 10.1016/j.oraloncology.2020.104684 [Article Type] Review article
Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in FerretsResearch Article Published on 2020-05-222022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Affect Antibody titers Antiviral antiviral drug antiviral efficacy antiviral therapeutics approved candidate Clinical outcome Clinical symptoms clinics control group coronavirus CoV COVID-19 COVID-19 patients debate did not reduce discrepancy disease drug Drug efficacy drug treatment effective vaccine Effectiveness Efficacy exhibited FDA-approved drug ferret ferrets future therapeutic group health care systems humans Hydroxychloroquine hydroxychloroquine sulfate identify Immune suppression Immunosuppressed Immunosuppression immunosuppressive in vivo Infection information Lopinavir-ritonavir mortalities nasal nasal washe Nasal washes patients phosphate-buffered saline Postinfection proceed Prolonged infection public health reduced regulatory agencies Repurposed drug required respiratory tissue resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Serum Neutralization severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly significantly lower specimens Spread Stool suggested susceptible tested therapeutic drug Therapeutic treatment treated Treatment Trial trials viral infection virus clearance virus titer virus titers were assessed while [DOI] 10.1128/mBio.01114-20 PMC 바로가기 [Article Type] Research Article
Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in ArgentinaPolicy Published on 2020-05-132022-10-31 Journal: ecancermedicalscience [Category] COVID-19, [키워드] acute respiratory syndrome Administered Analysis appear approved arising Betacoronavirus Cancer cancer patient Cancer patients Care caused Consensus coronavirus country COVID-19 Delphi method effort epidemiologically Evidence exceptional Final General population global pandemic guidelines healthcare Healthcare professional hospital hospitalised immunosuppressive international public health involved joint management measure multidisciplinary approach National objective outbreak pandemic status Participants Patient Perspective Radiotherapy recommendation resources Result SARS CoV-2 shifting susceptible therapy Topic Treatment viral infection World Health Organisation [DOI] 10.3332/ecancer.2020.1044 PMC 바로가기 [Article Type] Policy
Implications of COVID-19 Outbreak on Immune Therapies in Multiple Sclerosis Patients—Lessons Learned From SARS and MERSImmunology Published on 2020-05-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Acetate acute respiratory syndrome addition Anti-CD20 antibody Care coronavirus Coronavirus-2 COVID-19 depleting disease DMTs drugs fumarate Health higher risk humans immune Immunocompromised patients Immunological response immunosuppressive immunosuppressive therapy Immunosuppressive treatment Immunotherapy increased risk Infection interferons knowledge lymphopenia many cases MERS Middle East Multiple multiple sclerosis neurologist Novel coronavirus outbreak pandemic Patient question risk Safe SARS SARS- and MERS-CoV SARS-CoV-2 sclerosis severe disease course shown syndrome therapy transfer Treatment [DOI] 10.3389/fimmu.2020.01059 PMC 바로가기 [Article Type] Immunology
Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroidsArticle Published on 2020-05-082022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 임상, 치료법, [키워드] accelerate anti-IL6 antibody benefit cell entry Characteristics clinical benefit Controlled clinical trial correlated Corticosteroid Corticosteroids COVID-19 COVID-19-related death cytokine essential element fatal disease humans Hypothesis IL6 immune system Immunoglobulin immunoglobulins immunosuppressive IMPROVE Inflammation interleukin 6 monoclonal antibody Novel coronavirus outcomes Patient patients with COVID-19 pro-inflammatory cytokine Prognosis prognosis of patient rationale reduce SARS-CoV2 severe COVID-19 severity shown target targeted therapy therapeutic option therapy Treatment use of corticosteroid Viral load with COVID-19 [DOI] 10.1016/j.intimp.2020.106560 PMC 바로가기 [Article Type] Article