The 20th Anniversary Meeting of the Rocky Mountain Virology AssociationConference Report Published on 2020-12-292022-10-28 Journal: Viruses [Category] Coronavirus, MERS, SARS, [키워드] anniversary Antiviral concerning coronavirus coronavirus spike proteins COVID-19 pandemic described disease effector cell flavivirus herpesvirus host-virus interaction Immune suppression Immunity infections information innate immune response life-long immunity meeting Mountain mucosal tissues poxviruses prion Research retrovirus selected T-cell vaccination Virology virus Zika virus [DOI] 10.3390/v13010038 PMC 바로가기 [Article Type] Conference Report
Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study Research Published on 2020-12-282022-10-05 Journal: The Journal of Antibiotics [Category] 치료제, [키워드] 96 well plate antimicrobial antimicrobial agents Antiviral antiviral agent ATP Bacteria Bacterial bacterial culture benzethonium chloride Concentration COVID-19 demonstrated determine Donor E. coli Effect effective Efficacy Escherichia Escherichia coli FDA growth highlight ingredient inhibit innate immune response involved nitric oxide optical pilot study reduction in SARS-CoV-2 viable cells virus was used [DOI] 10.1038/s41429-020-00397-9 [Article Type] Research
A distinct innate immune signature marks progression from mild to severe COVID-19뚜렷한 타고난 면역 신호는 경증에서 중증 COVID-19로의 진행을 나타냅니다.Article Published on 2020-12-262022-09-11 Journal: Cell Reports Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] appearance CCL3 CCL4 CD16 CD169 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytometry emergency granulopoiesis healthy individuals identify IFN-γ immune responses immune signature Inflammation inflammatory phenotype Inflammatory response Inflammatory responses innate immune innate immune response innate response mass cytometry mechanism Mild mild COVID-19 patient mild COVID-19 patients mild or severe Covid-19 MIP1α monocyte Monocytes observé Patient progression proteomics sampling SARS-CoV-2 severe COVID-19 severe disease severe patients sialoadhesin sialoadhesin. signature Stage stages sustained symptom onset targeted intervention targeted interventions trajectory [DOI] 10.1016/j.xcrm.2020.100166 PMC 바로가기 [Article Type] Article
Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip SystemFull Paper Published on 2020-12-212022-10-28 Journal: Advanced Science [Category] COVID-19, [키워드] accelerate activated acute respiratory syndrome alleviate alveolar alveolar epithelium Analysis cause caused cell types circulating coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 disease Disease model Drug testing Endothelium exacerbated exhibit feature global pandemic Human human disease Immune cell immune cell recruitment immune response in vitro Infection Inflammation Inflammatory cytokine inhibit Injury innate immune response involved Lung injury Model organ organ chip pathway platform provide Remdesivir Research response SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 susceptibility System unique viral infection viral replication virus [DOI] 10.1002/advs.202002928 PMC 바로가기 [Article Type] Full Paper
The SARS-CoV-2 RNA–protein interactome in infected human cellsArticle Published on 2020-12-212022-10-04 Journal: Nature Microbiology [Category] MERS, SARS, 치료제, [키워드] ATP1A1 cellular cellular pathway changes in CNBP complex Contact demonstrated evaluated Factor function Genetic Host host cell human cell human cell lines human cells human protein IMPROVE infected cell Infection innate immune response Interaction LARP1 PPIA Protein proteome proteomics purification reduced restrict RNA RNA metabolism SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 replication SARS-CoV-2 RNA SARS-CoV-2 viral RNA the SARS-CoV-2 viral infection viral replication Viral RNA Virology [DOI] 10.1038/s41564-020-00846-z PMC 바로가기 [Article Type] Article
Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs새로운 코로나바이러스(SARS-CoV-2)에 대한 면역요법 개발을 위한 세포 및 분자 면역학 접근법: 가까운 미래의 돌파구에 대한 도전Review Published on 2020-12-192022-09-10 Journal: Journal of Immunology Research [Category] MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome addressed approach caused cellular and molecular challenge clinical outcomes coronavirus Course COVID-19 development dysfunction Effect Factor health system health systems hemostatic disorder hemostatic disorders high mortality rate Host immunology immunomodulatory effect immunopathology immunotherapies Immunotherapy improve clinical outcomes Infectious disease information innate immune response Interaction knowledge mechanism New New coronavirus pulmonary tract respiratory respiratory viral disease SARS-CoV-2 Scientific community Severe acute respiratory syndrome therapy Treatment treatment of COVID-19 Trigger Vaccine Vaccines Viral viral disease [DOI] 10.1155/2020/8827670 PMC 바로가기 [Article Type] Review
SARS-Cov-2 Interactome with Human Ghost Proteome: A Neglected World Encompassing a Wealth of Biological DataCommunication Published on 2020-12-192022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] addition Affinity purification alternative ORF alternative protein anti-viral response Biological cellular co-immunoprecipitation co-IP COVID-19 outbreak database DMPK Drug repurposing eukaryotic Evidence function functional Ghost ghost protein host cell Human identify initial innate immune response Interaction interactions interactome interactomics involved metabolism missing mRNA ncRNAs Neglected non-coding RNA OpenProt ORF Perspective pharmacokinetic physiological predicted Protein proteome proteomics responsible SARS-CoV-2 target the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic strategies therapeutic targets Therapies thought translated translation Viral protein Viral proteins [DOI] 10.3390/microorganisms8122036 PMC 바로가기 [Article Type] Communication
Extracellular RNA as a Versatile DAMP and Alarm Signal That Influences Leukocyte Recruitment in Inflammation and InfectionCell and Developmental Biology Published on 2020-12-182022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] Activation activity administration alarm arteriogenesis Bacteria Blood cells bypasses cardiovascular disease circulating cofactor condition Contact COVID-19 DAMP DAMPs danger-associated molecular patterns defense process demonstrated dissemination docking edema effective endothelial endothelial cells Endothelium ENhance Extracellular extracellular nucleic acids growth help histone host cell immune defense implicated in vitro in vivo include Inflammation Inflammatory inflammatory macrophages inflammatory vascular diseases influence initiate innate immune response Interaction intracellular material Invasion investigated Ischemia leukocyte limit microbial microbial infection microRNA molecular Non-coding RNAs non-toxic nucleic acid pro-thrombotic promote provide provoke Reactions recruitment regimen RNA RNase1 Safe signal subsequent therapeutic thrombosis tissue damage Vascular Vascular injury VEGF vessel vessel wall viral infection viral particle virus virus infection while wound healing [DOI] 10.3389/fcell.2020.619221 PMC 바로가기 [Article Type] Cell and Developmental Biology
Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral ProteinsChemistry Published on 2020-12-102022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] biological processe cellular conserved coronavirus Coronaviruses COVID19 DDX helicases expected function functional Helicase homology Host host cell Human information innate immune response Interaction involved key factor mechanisms Multiple parasites protein structure Proteins replicate Replication responsible RNA SARS-CoV-2 shown the SARS-CoV-2 viral infection Viral protein viral replication virus Virus life cycle [DOI] 10.3389/fchem.2020.602162 PMC 바로가기 [Article Type] Chemistry
Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathologyShort Communication Published on 2020-12-082022-10-29 Journal: Oxford Open Immunology [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome cause caused cellular Coagulation contribute coronavirus coronavirus disease COVID-19 damage-associated molecular pattern Disease progression driven by dysregulated dysregulated immune response Effectiveness effort fibrosis Health high mortality highlighting hyperinflammation IL-10 immunology immunopathology Inflammation Inflammatory initial Innate innate immune innate immune response Innate immunology intensive care Intervention kidney knowledge leukocyte lung Macrophage macrophages Monocytes natural killer cell Neutrophil extracellular trap Neutrophils NK cells outcome pandemic Part pathogen-associated molecular pattern pathology Patient promote public health reducing mortality responses responsible SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe COVID-19 patients suppressed syndrome tissues Treatment type I interferon worsened [DOI] 10.1093/oxfimm/iqaa005 PMC 바로가기 [Article Type] Short Communication