Diagnostic accuracy of loop-mediated isothermal amplification coupled to nanopore sequencing (LamPORE) for the detection of SARS-CoV-2 infection at scale in symptomatic and asymptomatic populationsOriginal Article Published on 2021-04-242022-10-04 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome Asymptomatic can be used Cohort coronavirus coronavirus disease detection Diagnostic accuracy diagnostic sensitivity diagnostics Effectiveness health-care identify incidence investigated isothermal amplification Loop-mediated isothermal amplification methodology Nanopore Nasopharyngeal swab nasopharyngeal swabs objective Oxford pandemic participant Patient Population populations prospective cohort Quantitative Rapid rapid testing reagent Result retrospective retrospective cohort RNA RT-PCR RT-qPCR RT-qPCR test Saliva SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection SARS-CoV-2 RNA Sensitivity and specificity Sequencing sequencing technology severe acute respiratory syndrome Coronavirus specificity specimen Swab symptomatic symptomatic and asymptomatic symptomatic infections tested was used [DOI] 10.1016/j.cmi.2021.04.008 PMC 바로가기 [Article Type] Original Article
Evaluation of pooling of samples for testing SARS-CoV- 2 for mass screening of COVID-19COVID-19의 대량 스크리닝을 위한 SARS-CoV-2 검사를 위한 샘플 풀링 평가Research Published on 2021-04-172022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 진단, [키워드] affected balance benefit calculated Care coefficient Coefficient of variance country COVID COVID-19 Critical cycle threshold determine Diagnosis effective evaluate evaluated False negative Health Organization high variability Infection Infectious disease Infectious diseases Infrastructure inter- and intra-assay limitation limitations management Mass screening Nasopharyngeal swab nasopharyngeal swabs other respiratory infection other respiratory infections pandemic positive positive patients positive sample Precision provided resource respiratory respiratory infections Result robust sample pool Sample pooling SARS-CoV SARS-CoV-2 SARS-CoV-2 virus sensitivity situation solution the patient the SARS-CoV-2 virus Variability variance Viral Viral load WHO World Health Organization [DOI] 10.1186/s12879-021-06061-3 PMC 바로가기 [Article Type] Research
Accuracy of rapid antigen detection test for nasopharyngeal swab specimens and saliva samples in comparison with RT-PCR and viral culture for SARS-CoV-2 detectionOriginal Article Published on 2021-04-172023-06-16 Journal: Journal of infection and chemotherapy : official j [Category] MERS, SARS, [키워드] Ct, threshold cycle nasopharyngeal swabs NPS, nasopharyngeal swab RAD, Rapid antigen detection rapid antigen detection test RT-PCR, Reverse transcription PCR Saliva SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 viral culture [DOI] 10.1016/j.jiac.2021.04.010 PMC 바로가기 [Article Type] Original Article
When the COVID-19 Pandemic Surges during Influenza Season: Lessons Learnt from the Sentinel Laboratory-Based Surveillance of Influenza-Like Illness in Lombardy during the 2019–2020 Season인플루엔자 시즌 동안 COVID-19 대유행이 급증할 때: 2019–2020 시즌 동안 롬바르디아의 인플루엔자 유사 질병에 대한 Sentinel 연구소 기반 감시에서 배운 교훈Article Published on 2021-04-162022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] age children circulation collected COVID-19 FIVE greater group ILI illness infected with SARS-CoV-2 Influenza Influenza virus influenza viruses influenza-like illness influenza-like illnesses Italy Laboratory lesson lombardy molecular detection Molecular epidemiology Nasopharyngeal swab nasopharyngeal swabs NPSs Outpatient physician positive real-time RT-PCR remained risk RSV RT-PCRs SARS-CoV-2 season sentinel Seven Spread Surveillance surveillance network tested virus [DOI] 10.3390/v13040695 PMC 바로가기 [Article Type] Article
Comparison of viral load between saliva and nasopharyngeal swabs for SARS-CoV2: the role of days of symptoms onset on diagnosisOriginal Article Published on 2021-04-162022-10-29 Journal: Memórias do Instituto Oswaldo Cruz [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Ageusia Anosmia collected coronavirus Coronavirus disease 2019 cough COVID-19 COVID-19 diagnosis death decrease Diagnosis evaluate fatigue Fever FIVE Headaches healthcare mild symptoms myalgia Nasopharyngeal swab nasopharyngeal swabs nine no significant difference presenting reduce reported rhinorrhea risk of infection RT-PCR Saliva saliva specimen SARS-CoV-2 sensitivity significant changes in sore throat specimen subject Swab symptoms onset Viral load was performed [DOI] 10.1590/0074-02760210018 PMC 바로가기 [Article Type] Original Article
Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 PatientsCOVID-19 환자의 소변에서 SARS-CoV-2 스파이크 단백질에 대한 증거Article Published on 2021-04-142022-09-11 Journal: Kidney360 [Category] SARS, 치료기술, [키워드] Acute kidney injury acute kidney injury and ICU nephrology affected albumin albuminuria Analysis Antigen antigen capture assay Asymptomatic Awareness be positive body fluids children Children's Hospital collected consequence coronavirus correlation COVID-19 creatinine cystatin C deaths detect detectable develop Diagnosis enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay ICU in urine individual infected with SARS-CoV-2 Infection majority Nasopharyngeal swab nasopharyngeal swabs New one individual pandemic participant participants with SARS-CoV-2 Patient Philadelphia positive positive PCR positive PCR result raised renal abnormalities S1 protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein spike spike glycoprotein Spike protein statistical Urine viral envelope proteins viral envelope proteins. Viral RNA [DOI] 10.34067/KID.0002172021 PMC 바로가기 [Article Type] Article
Comparison of Throat Washings, Nasopharyngeal Swabs and Oropharyngeal Swabs for Detection of SARS-CoV-2SARS-CoV-2 검출을 위한 인두 세척액, 비인두 면봉 및 구인두 면봉의 비교Comparative Study Published on 2021-04-102022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome coronavirus 2 analysed Concentration concentrations coronavirus coronavirus 2 COVID-19 detection diagnostic diagnostic sensitivities diagnostic sensitivity diagnostics median Nasopharyngeal swab nasopharyngeal swabs nucleic acid test oropharyngeal swab oropharyngeal swabs Patient PCR quantification quantitative real-time PCR respiratory respiratory specimens RNA RT-qPCR Saliva SARS-CoV-2 SARS-COV-2 infection sensitivity Severe acute respiratory syndrome Throat throat washing [DOI] 10.3390/v13040653 PMC 바로가기 [Article Type] Comparative Study
Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial페루의 초기 COVID-19 환자(SAINT-Peru)에서 비인두 PCR을 무효화하기 위해 이버멕틴 대 위약의 효능을 비교하기 위한 무작위 임상 시험(SAINT-Peru): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-092022-09-01 Journal: Trials [Category] MERS, 임상, 진단, [키워드] 1:1 Administered adverse event allergy Amiodarone Anosmia Antiviral attending physician baseline blinded Blinding block childbearing age clarithromycin clinical clinical and laboratory parameters clinical care clinical trial Cobicistat coin conducted control group correlation cough COVID-19 COVID-19 disease COVID-19 patient COVID-19 pneumonia COVID-19 progression criteria Critical current cyclosporine CYP3A4 daily dose death determine determined by diagnosed diagnostic test Diltiazem dissemination dose drug early treatment Efficacy element Eligible patients emergency services enrolled epidemiologist erythromycin evaluate expected Fever follow-up visits generate hospital Hospitalization IgA IgG IgM IIa immune response immunomodulatory in vivo include inclusion criteria Indinavir Infection Informed consent inhibitor Intervention intestinal investigator investigators involved itraconazole Ivermectin ketoconazole laboratory parameter less list lung magnitude medical staff nasopharyngeal nasopharyngeal specimen Nasopharyngeal swab nasopharyngeal swab PCR nasopharyngeal swabs National negative number objective Older outcome oxygen oxygen saturation Parallel Arm participant Patient patients patients with SARS-CoV-2 PCR PCR cycle Peru Pharmacist phase Placebo placebo group placebo-controlled trial Pneumonia positive positive PCR test positive SARS-CoV-2 PCR pregnancy test pregnant women principal investigator progression proportion protocol quinidine randomization list Randomized Randomized controlled trial Randomly Rapid diagnostic test receive recruited reduce Registered Registration Result risk factor Risk factors Ritonavir Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR SARS-CoV-2 RNA SARS-CoV-2 viral load secondary Secondary objectives Seroconversion Seven severe disease severity spironolactone statistician status study population Study protocol supplementary material Symptom symptomatic Symptomatology Symptoms tacrolimus the patient the placebo group the SARS-CoV-2 threshold Treatment treatment group treatment groups treatment initiation Trial Trial registration two group two groups verapamil Viral Viral load virus Warfarin website with COVID-19 women [DOI] 10.1186/s13063-021-05236-2 PMC 바로가기 [Article Type] Letter
CovidArray: A Microarray-Based Assay with High Sensitivity for the Detection of Sars-Cov-2 in Nasopharyngeal SwabsCovidArray: 비인두 면봉에서 Sars-Cov-2 검출을 위한 고감도 마이크로어레이 기반 분석Article Published on 2021-04-032022-09-10 Journal: Sensors (Basel, Switzerland) [Category] MERS, SARS, 진단, 치료기술, [키워드] Amplicon Analysis analytical sensitivity analyzed approach assigned Asymptomatic individuals caused Chain Reaction conditions coronavirus coronavirus disease COVID-19 decrease detect detection diagnostic DNA Epidemic False negative false negatives false-negative false-negative results gold gold standard greater identify involved less marker Microarray microarray-based assay molecular diagnostics N1 and N2 nasopharyngeal swabs New coronavirus polymerase chain polymerase chain reaction quantitative polymerase chain reaction reduction reported reverse transcription RNA extraction RT-qPCR SARS-CoV-2 sensitivity silicon specificity substrate surface chemistry swab samples swabs Viral viral gene viral genes Viral RNA viral RNA extraction [DOI] 10.3390/s21072490 PMC 바로가기 [Article Type] Article
Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers커뮤니티 기반 테스트 센터의 진료 현장에서 두 가지 상용 SARS-CoV-2 항원 검출 빠른 테스트의 진단 정확도Research Article Published on 2021-03-312022-08-13 Journal: PLoS ONE [Category] Biology and Life Sciences, COVID-19, SARS, [키워드] (Abbott 95% CI Abbott Accuracy Ag-RDT Ag-RDTs best Characteristics criteria diagnostic Diagnostic accuracy diagnostic tests diagnostic value enrolled False positive Fever independent individual individuals Laboratory less Lower nasopharyngeal swabs objective PanBio participant Participants Patient performed point of care positive positive RT-PCR presenting Rapid Rapid diagnostic test Rapid test Result Roche RT-PCR SARS-CoV-2 SD Biosensor sensitivity single-center specificity Standard Q Ag-RDT structures Symptom symptom onset symptomatic Test Testing typical symptom typical symptoms was obtained WHO criteria yielding [DOI] 10.1371/journal.pone.0248921 PMC 바로가기 [Article Type] Research Article