Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 의한 기간 태반 감염에 대한 임상 및 시험관 내 증거Clinical Trial Published on 2021-09-012022-09-11 Journal: The American journal of pathology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell clinical consequence coronavirus coronavirus 2 coronavirus disease Defense demise during pregnancy enzyme expression fetus Host immunohistochemistry In situ hybridization Infection mechanism membrane mother Newborn not express Placenta Placental infection Placentas positive control Pregnancy Pregnancy confirmed protease Protein quantification question raise receptor Replication respiratory reverse transcriptase reverse transcriptase PCR SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virions Serine serine 2 severe acute respiratory syndrome Coronavirus supernatant syncytium term TMPRSS2 transmembrane transmembrane protease serine 2 Transmission undetectable Vero E6 vertical transmission virus [DOI] 10.1016/j.ajpath.2021.05.009 PMC 바로가기 [Article Type] Clinical Trial
Enhancing the Stability of COVID-19 Serological Assay through Metal-Organic Framework Encapsulation금속-유기 프레임워크 캡슐화를 통한 COVID-19 혈청학적 분석의 안정성 향상Article Published on 2021-09-012022-09-11 Journal: Advanced Healthcare Materials [Category] SARS, 진단, 치료기술, [키워드] alleviate among others antibody Antigen antigens approach biospecimens Clinical data complementary condition conformational conformational epitopes COVID-19 COVID-19 patient COVID-19 patients Critical demonstrated diagnostic reagent diagnostic reagents Disease surveillance effective electricity elements elevated temperature encapsulation Enhancing enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay enzyme-linked immunosorbent assays epitope Epitopes framework growth handling IMPROVE inaccessible metal-organic frameworks plasma sample plasma samples preservation quantification refrigeration resource-limited settings. SARS-CoV-2 SARS-CoV-2 antigens serologic assays stability storage conditions Surveillance temperature the disease [DOI] 10.1002/adhm.202100410 PMC 바로가기 [Article Type] Article
Imaging of COVID-19: An update of current evidencesMini review Published on 2021-09-012022-10-05 Journal: Diagnostic and interventional imaging [Category] 진단, [키워드] acute respiratory syndrome approach artificial intelligence cardiac cardiac magnetic resonance cardiovascular complication caused Chest computed tomography Computed tomography coronavirus Coronavirus disease 2019 COVID-19 CT findings death Diagnosis diagnosis of COVID-19 diagnostic Diseases dysfunction Evidence imaging magnetic resonance imaging management myocardial involvement patients with COVID-19 Pulmonary embolism quantification recent reported SARS-CoV-2 SARS-COV-2 infection the disease worsening [DOI] 10.1016/j.diii.2021.05.006 [Article Type] Mini review
Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α사이토카인 폭풍과 COVID-19 관련 사망 사례 60건의 조직병리학적 발견: 바이러스 부하 연구에서 주요 선수 IL-1β, IL-6, IL-15 및 TNF-α의 면역조직화학적 정량화에 이르기까지Original Article Published on 2021-08-312022-09-11 Journal: Forensic Science, Medicine, and Pathology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar capillary antibody ARDS Autopsies Autopsy CD20 CD4 CD45 CD8 Cell collected control group COVID-19 COVID-19 group COVID-19 related-death current cytokine Cytokine storm Cytokines death Endothelial cell endothelial cells evaluate Evidence expressed expression fibrinogen histological analysis histopathological finding Hypothesis IL-10 IL-15 IL-1β IL-6 immunohistochemical staining immunohistochemistry immunoreactivity inflammatory cell inflammatory cells Inflammatory cytokine lung MCP-1 multiple cytokine multiple cytokines multiple organ failure nasopharynx nucleoprotein organs oropharynx outcomes overexpression Pneumonia positive Proinflammatory cytokine proinflammatory cytokines quantification Research respiratory respiratory distress RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR selected Spike protein Swab swabs syndrome T cells tested the spike protein tissue TNF-α Trachea Viral load virus [DOI] 10.1007/s12024-021-00414-9 PMC 바로가기 [Article Type] Original Article
A rapid and simple protocol for concentration of SARS-CoV-2 from sewageArticle Published on 2021-08-262022-10-04 Journal: Journal of virological methods [Category] MERS, SARS, 치료기술, [키워드] average buffer centrifugation chloride circulation collected Community Concentration Detection limit Detection sensitivity Diagnosis Environmental surveillance equipment Final glycol increase in incubated indicated inhibitor lab Laboratory Particle pellet produced protocol purification quantification reduce resources resuspended RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA detection sewage Support Surveillance virus concentration Volume wastewater based epidemiology [DOI] 10.1016/j.jviromet.2021.114272 PMC 바로가기 [Article Type] Article
CBmeter study: protocol for assessing the predictive value of peripheral chemoreceptor overactivation for metabolic diseasesClinical Trial Published on 2021-08-262022-10-05 Journal: BMJ Open [Category] SARS, 임상, [키워드] Algorithms analysed Analysis approved asked carotid clinical study Clustering analysis coded contribute diabete diabetics Diagnosis disease early diagnosis ethics committee Glucose gold standard guidelines Health health informatics healthcare Healthcare systems ingestion interstitial Intervention metabolic disease metabolic disturbances Non-invasive Oxygen administration oxygen saturation participant Patient peer-reviewed peripheral chemoreceptor Physiology Predictive protocol protocols & quantification recent recruited respiratory rate response Result Stratification Therapeutic approach type 2 diabete ventilatory [DOI] 10.1136/bmjopen-2020-042825 PMC 바로가기 [Article Type] Clinical Trial
Early warning and rapid public health response to prevent COVID-19 outbreaks in long-term care facilities (LTCF) by monitoring SARS-CoV-2 RNA in LTCF site-specific sewage samples and assessment of antibodies response in this population: prospective study protocolLTCF 현장별 하수 샘플에서 SARS-CoV-2 RNA를 모니터링하고 이 인구집단에서 항체 반응을 평가하여 장기 요양 시설(LTCF)에서 COVID-19 발생을 예방하기 위한 조기 경보 및 신속한 공중 보건 대응: 전향적 연구 프로토콜Article Published on 2021-08-202022-09-11 Journal: BMJ Open [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 24 hour 24 hours Abstract Analysis antibody Antibody assays Antibody Response Antibody testing approval Asymptomatic COVID-19 benefit board Care correlation COVID-19 COVID-19 case COVID-19 outbreak COVID-19 pandemic COVID-19 vaccination COVID-19 vaccines discomfort dissemination Early detection effective Efficacy Epidemiology Ethics followed by force Health health economics high morbidity and mortality immune response Immunity immunology implementation include Infection infection control information Laboratory Long-term care Longevity manuscript measure molecular MONITOR morbidity and mortality Neutralising Antibodies neutralising antibody notification outbreak Outbreak investigation pandemic participant Participants peer-reviewed performed presymptomatic Prevent Prospective Study protocol Public public health quantification Research Ethics risk robustness SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 RNA Scientific community Study participants Support Task Force the antibody response Transmission university Vaccine variant was obtained [DOI] 10.1136/bmjopen-2021-052282 PMC 바로가기 [Article Type] Article
Nasopharyngeal Testing among Healthcare Workers (HCWs) of a Large University Hospital in Milan, Italy during Two Epidemic Waves of COVID-19Observational Study Published on 2021-08-192022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 임상, [키워드] association collected conducted COVID-19 defined demographic characteristics Epidemic epidemic wave Frequency HCW HCWs healthcare operators infection rate Italy Nasopharyngeal swab NPs occupational positive quantification Reinfection retrospective RNA SARS-CoV-2 SARS-CoV-2 epidemic SARS-CoV2 Spread subject tested Testing university university hospital Wave worker [DOI] 10.3390/ijerph18168748 PMC 바로가기 [Article Type] Observational Study
Hydroxychloroquine serum concentration in coronavirus disease 2019 (COVID-19) patients: a retrospective studyResearch Article Published on 2021-08-192022-10-31 Journal: Forensic Sciences Research [Category] COVID-19, [키워드] accompanied administration adopted AIDS Algeria analyzed blood sample coefficient Concentration coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-2019 females forensic sciences French greater HCQ Hospitalized HPLC-DAD Hydroxychloroquine Infection less limit majority male monitoring Patient patients treated patients with COVID-19 Personalization pharmacological plasma Point protocol quantification recommendation retrospective Retrospective study SARS-CoV-2 serum Side effect team the patient therapeutic Tolerance Toxicity Treatment treatment for COVID-19 was performed [DOI] 10.1080/20961790.2021.1936896 PMC 바로가기 [Article Type] Research Article
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patientsShort Communication Published on 2021-08-172022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] addition admitted to ICU antibody antiviral immune response association autoantibodies autoantibody circulating Clinical characteristics Clinical course Clinical outcome Cohort Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Critically ill critically ill patients Deleterious evaluate explained France higher risk hospice ICU IFN Immunity impairment IMPROVE intensive care unit majority Mild neutralising Neutralising activity neutralize no significant difference objective outcome pandemic progresses Patient positive Prevalence quantification reported Result SARS‐CoV‐2 virus sera serum subset subtype the disease Thermo Fisher type I Type I IFN type I interferon viral infection was determined [DOI] 10.1002/cti2.1327 PMC 바로가기 [Article Type] Short Communication