Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking네트워크 약리학 및 분자 도킹을 통한 COVID-19의 처리를위한 Xuebijing 주입의 분자 표적 및 메커니즘 식별Research Article Published on 2021-06-022022-08-31 Journal: Bioengineered [Category] 치료제, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom Clinical symptoms connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection lipopolysaccharide Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened STRING target TCMSP therapeutic target therapeutic targets TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis콜히친 치료는 코로나바이러스 질병 2019(COVID-19)의 결과를 개선할 수 있습니다: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-06-012022-09-11 Journal: Clinical and experimental pharmacology & physiolog [Category] SARS, 임상, [키워드] 95% CI administration Analysis article benefit clinical trial Colchicine colchicine treatment coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients database effective Efficacy eight Europe immune immune therapy IMPROVE Inflammation Inflammatory diseases Meta-analysis mortality rate Newcastle-Ottawa Scale NOS observational studies observational study offer outcome PMC randomized clinical trial randomized trial randomized trials reducing reduction retrieved review RoB 2 searched severe COVID-19 shown statistical analysis systematic review the Newcastle-Ottawa Scale Treatment was done [DOI] 10.1111/1440-1681.13488 PMC 바로가기 [Article Type] Meta-Analysis
Intubation rate of patients with hypoxia due to COVID-19 treated with awake proning: A meta-analysisResearch article Published on 2021-05-012022-10-05 Journal: The American journal of emergency medicine [Category] 비임상, [키워드] 95% CI age Analysis articles Awake proning Case series conducted coronavirus COVID-19 database demonstrated Efficacy Evolution feasible heterogeneity hypoxia hypoxic patient identify Intervention intubation intubation rate men Meta-analysis meta-regression Moderator analysis mortality rate Newcastle-Ottawa Scale noninvasive Noninvasive ventilation NOS observational studies oxygen Patient patients with COVID-19 performed Potential Primary outcome prone positioning proning Random-effects meta-analysis Randomized control trials Research Result searched Study design the disease treated Treatment strategies ventilatory support with COVID-19 [DOI] 10.1016/j.ajem.2021.01.058 [Article Type] Research article
Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19COVID-19에 대한 잠재적인 치료 옵션을 제공하기 위해 SARS 및 MERS 치료에서 LPV/r 약물의 효능 및 안전성에 대한 종합 평가Meta-Analysis Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addition adverse event adverse events age and sex analyzed Antiviral treatment applied ARDS assessment tool benefit bias risk case-control studies CBM Chest CT China CNKI Cochrane Library Cohort studies Combination comprehensive evaluation conducted control group conversion rate coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 treatment database drug effective Effectiveness Efficacy Efficacy and safety eligible evaluate exhibited Factor incidence Infrastructure literature Lopinavir Lopinavir/ritonavir lower mortality LPV/r MERS Meta-analysis Middle East Middle East respiratory syndrome molecular Newcastle-Ottawa Scale NOS nucleic acid outbreak outcome patients patients with COVID-19 patients with SARS performed potential treatment option prognostic Randomized controlled studies RCT reduced Registration respiratory respiratory distress retrieved Risk assessment Ritonavir SARS Severe acute respiratory syndrome significantly similarities similarity statistically significant Structure syndrome systematic review the Newcastle-Ottawa Scale these viruses Treatment treatment of COVID-19 Trial two group two groups virus clearance viruses was used were used [DOI] 10.18632/aging.202860 PMC 바로가기 [Article Type] Meta-Analysis
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein내피 세포 손상은 COVID-19의 중심 부분이며 스파이크 단백질의 S1 서브유닛을 주입하여 유도된 마우스 모델Article Published on 2021-04-012022-09-11 Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Autopsy Behavior Brain Brain tissues C5b-9 caspase caspase 3 caspase-3 cell damage Complication COVID-19 demonstrated detect diagnostic died endothelial Endothelial cell endothelial cell damage endothelial damage envelope eosin examined fatal COVID-19 full length hematoxylin Hematoxylin and eosin host response IL6 immunohistochemistry increased thirst incubated injected injection Localization membrane protein Membrane proteins MFSD2a mice neurologic neurologic signs Neuron neuronal neuronal cell neuronal cells NOS pathologist pathology positive Protein Proteins pseudovirion pseudovirions S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV2 SHIP1 spike Spike protein subunit subunits symptomatic symptomatic COVID-19 tail the S1 subunit the spike protein tissue TNFα Viral RNA were used wild type [DOI] 10.1016/j.anndiagpath.2020.151682 PMC 바로가기 [Article Type] Article
Frailty as a predictor of mortality among patients with COVID-19: a systematic review and meta-analysisResearch Article Published on 2021-03-172022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] addition Analysis association CFS clinician Cochrane Library COVID-19 COVID-19 patients effect size eight Evidence frailty group hazard ratio hospitalized patient increased risk independent indicate indicated Intervention Meta-analysis Mortality NOS Nurse Odds ratio Older adults Patient patients with COVID-19 performed positive Prevalence Prognostic factor Quantitative analysis random effect reduce mortality rate Result SARS-CoV-2 scale searched sensitivity analysis Stata Study design subgroup analysis supplementary material systematic review was used were infected with COVID-19 [DOI] 10.1186/s12877-021-02138-5 PMC 바로가기 [Article Type] Research Article
Frailty as a predictor of mortality among patients with COVID-19: a systematic review and meta-analysisResearch Article Published on 2021-03-172022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, SARS, [키워드] addition Analysis association CFS clinician Cochrane Library COVID-19 COVID-19 patients effect size eight Evidence frailty group hazard ratio hospitalized patient increased risk independent indicate indicated Intervention Meta-analysis Mortality NOS Nurse Odds ratio Older adults Patient patients with COVID-19 performed positive Prevalence Prognostic factor Quantitative analysis random effect reduce mortality rate Result SARS-CoV-2 scale searched sensitivity analysis Stata Study design subgroup analysis supplementary material systematic review was used were infected with COVID-19 [DOI] 10.1186/s12877-021-02138-5 PMC 바로가기 [Article Type] Research Article
Serial interval and incubation period of COVID-19: a systematic review and meta-analysisResearch Article Published on 2021-03-112022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] Analysis articles average carried CINAHL Cochrane Library conducted COVID-19 COVID-19 case cross-sectional study data extraction database determine diagnosed with COVID-19 Direct epidemiological evaluate Evidence Google Scholar IMPROVE Incubation period International MAA mean incubation period Meta-analysis Microsoft Excel NOS observational study parameter presymptomatic transmission Public health intervention R software random effect ranged Result Science Serial interval significantly supplementary material systematic review the mean Transmission dynamics understanding was used Web of Science [DOI] 10.1186/s12879-021-05950-x PMC 바로가기 [Article Type] Research Article