abrogated – Page 3 – Communicable Diseases Research

Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis

Article

Published on 2021-11-122022-10-04
Journal: Cell Death Discovery [Category] 바이오마커,

SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

Article

Published on 2021-11-032022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

[키워드] abrogated Activation acute respiratory syndrome Adhesion Molecule affected androgen androgen signaling angiotensin receptor blocker antagonism Cell circulating condition coronavirus Coronavirus-2 COVID-19 death defined diagnosed with COVID-19 Dihydrotestosterone E-selectin Effect endothelial Endothelial cell endothelial injury exacerbated exposure FDA-approved drug higher odd ICAM-1 in vitro Inflammatory cytokine marker men men and women Mineralocorticoid monocyte Necrosis patients hospitalized receptor reduced SARS-CoV-2 SARS-CoV-2 spike spike Spike protein spironolactone state tested therapeutic effect THP-1 TNF-α transcript Treatment vascular effect VCAM-1 were measured with COVID-19 women
[DOI] 10.3390/v13112209 PMC 바로가기 [Article Type] Article

Generation of False-Positive SARS-CoV-2 Antigen Results with Testing Conditions outside Manufacturer Recommendations: A Scientific Approach to Pandemic Misinformation

Research Article

Published on 2021-10-202022-10-30
Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS,

[키워드] Abbott abrogated acute respiratory syndrome Ag-RDT Ag-RDTs antibodies antibody Antigen Anxiety buffer Care claimed clinical methods component condition conditions conducted conformational change coronavirus coronavirus disease country COVID-19 Critical demonstrated diagnostics Direct dissemination Epidemiology experiment extreme False positive False-positive False-positive results generate Generation Health help Interaction Laboratory mechanism media misinformation NaCl nonspecific occur offer PanBio Panbio assay pandemic positive control professionals proteinase public health Reactions recommendation recommendations reduce required resources Result resulting SARS-CoV-2 SARS-CoV-2 antigen shown specimen Support supported temperature tested Testing Treatment Tween 20 Virology while
[DOI] 10.1128/Spectrum.00683-21 PMC 바로가기 [Article Type] Research Article

Increased risk of chronic fatigue and hair loss following COVID-19 in individuals with hypohidrotic ectodermal dysplasia

Research

Published on 2021-09-032022-10-29
Journal: Orphanet Journal of Rare Diseases [Category] COVID-19, SARS,

BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: a prospective, single-centre, longitudinal cohort study in health-care workers

BNT162b2 COVID-19 백신과 체액성 면역 반응 및 역학의 상관 관계: 의료 종사자를 대상으로 한 전향적, 단일 센터, 종단 코호트 연구

Observational Study

Published on 2021-09-012022-09-12
Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단,

[키워드] 95% CI abrogated administration age analyses anti-SARS-CoV-2 IgG antibody antibody concentration antibody kinetics Antibody Response Antibody test Autoimmune disease baseline BNT162b2 BNT162b2 vaccine breakthrough infections center Comorbidities Comorbidity concurrent correlation COVID-19 vaccine diabete disease domain dose elicited eligible Endpoint first dose Follow-up greater health-care high correlation highlighting humoral immune response hypertension IgA IgG IgG antibody IgG response IgM Immunosuppressed Immunosuppression individual individuals induce infection with COVID-19 initiated intramuscular linear mixed model linear regression analyses Logistic longitudinal cohort study Male sex Ministry of Health neutralisation neutralisation titre neutralising antibody neutralising antibody response neutralising antibody titres neutralising assay Older Older age over participant Participants Pfizer-BioNTech Population positive positive SARS-CoV-2 PCR receiving reduced regression analysis responses robust Scatter plot second dose second vaccination serological serology test serum sample significantly lower study population susceptible tested the receptor-binding domain the vaccine titre vaccination Vaccine vaccine dose were excluded were used
[DOI] 10.1016/S2213-2600(21)00220-4 PMC 바로가기 [Article Type] Observational Study

Mutants of human ACE2 differentially promote SARS-CoV and SARS-CoV-2 spike mediated infection

인간 ACE2의 돌연변이는 SARS-CoV 및 SARS-CoV-2 스파이크 매개 감염을 차등적으로 촉진합니다

Research Article

Published on 2021-07-162022-09-10
Journal: PLoS Pathogens [Category] SARS, 변종,

[키워드] abrogated abundance ACE2 ACE2 protein ACE2 sequence Affect allele bind binding biochemical Cell cell line cell surface cells change coding coronavirus coronavirus spike proteins correlated CoV spike proteins Cross-species transmission Cytopathic effect cytopathic effects determine Effect Efficiency engage events exomes expressed expression fraction Genetic genomic integration HEK 293T Human human ACE2 human Ace2 protein implication infect cells Infection inhibited Interaction Missense missense mutants Modification mutant mutants N501Y Non-linear relationship nucleotide overlapping parental promote Protein pseudotyped lentivirus pseudovirus entry pseudovirus infection Quantitative receptor protein reduced reducing reference sequence SARS-CoV SARS-CoV entry SARS-CoV-2 SARS-CoV-2 RBD binding SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike proteins SARS-CoV-2 spike variants SARS-like coronavirus SARS-like coronaviruses sequence single nucleotide Spike protein Spike proteins susceptibility susceptibility to infection target cell target cells the cell the spike protein transgenic unique variant variants Viral viral spike virus viruses while zoonotic
[DOI] 10.1371/journal.ppat.1009715 PMC 바로가기 [Article Type] Research Article

Inactivation of SARS-CoV-2 virus in saliva using a guanidium based transport medium suitable for RT-PCR diagnostic assays

RT-PCR 진단 분석에 적합한 구아니듐 기반 운송 배지를 사용하여 타액에서 SARS-Cov-2 바이러스의 불 활성화

Research Article

Published on 2021-06-112022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술,

[키워드] 1:1 abrogated buffer Cell culture chain Chain Reaction clinical sample clinical samples condition conditions Copan COVID-19 CPE Cytopathic effect detect detectable diagnostic Dilution downstream evaluated expand guanidinium hazard inactivated inactivation Incubation infectious limit of detection log media medium minute passages positive processing reaction remained respiratory respiratory sample Result room temperature RT-PCR Saliva sample collection SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 virus stability temperature tested Transport upper VeroE6 cell VeroE6 cells Viral Viral RNA virus
[DOI] 10.1371/journal.pone.0252687 PMC 바로가기 [Article Type] Research Article

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

최근 SARS-CoV-2 변이체에서 항원 드리프트의 구조적 및 기능적 파급효과

Report

Published on 2021-05-202022-09-10
Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, 진단,

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

Report

Published on 2021-04-302022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19,

Dysregulated Innate and Adaptive Immune Responses Discriminate Disease Severity in COVID-19

조절되지 않는 선천 및 적응 면역 반응이 COVID-19의 질병 중증도를 구별합니다

Article

Published on 2021-04-232022-09-11
Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커,

[키워드] abrogated adaptive Adaptive immunity Analysis Biomarkers Cell Clustering analysis COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients Critical Critically ill critically ill patients cytokine cytokine production Cytokines disease disease severity exhaustion markers flow cytometry hepatocyte growth factor highlight highlighting host response Hyperinflammatory immune response immune responses Inflammatory Inflammatory responses Innate innate immune innate immune response innate immune responses Innate immunity interferon interferon-γ interleukin interleukin-17 lymphopenia mononuclear cell performed Peripheral blood Plasma cytokine Potential biomarker potential biomarkers proinflammatory proteomics provide response Result stem cell stem cell factor T-cell exhaustion Variation Whole blood
[DOI] 10.1093/infdis/jiab065 PMC 바로가기 [Article Type] Article