SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential MechanismArticle Published on 2021-01-132023-06-15 Journal: Molecular neurobiology [Category] MERS, SARS, [키워드] ACE1 ACE2 Brain coronavirus COVID-19 headache Loss of consciousness Loss of Smell loss of taste nervous system Neuropilin-1 SARS-CoV-2 Seizures stroke [DOI] 10.1007/s12035-020-02245-1 PMC 바로가기 [Article Type] Article
No credible evidence for links between 2D:4D and COVID-19 outcomes: A probabilistic perspective on digit ratio, ACE variants, and national case fatalities2D:4D와 COVID-19 결과 사이의 연관성에 대한 신뢰할 수 있는 증거 없음: 숫자 비율, ACE 변종 및 전국 사례 사망률에 대한 확률론적 관점Article Published on 2021-01-012022-09-11 Journal: Early human development [Category] 변종, [키워드] 2D:4D absence ACE ACE1 ACE2 allele androgen angiotensin Angiotensin-converting enzyme article articles association Bayesian Bayesian analysis Bayesian inference COVID-19 COVID-19 mortality COVID-19 susceptibility Critical described digit ratio Digit ratio. evaluated Evidence evidence of fatality female frequencies Frequency Genotype Grounding Hypothesis male National offer outcome outcomes Perspective prenatal Prevalence prognostic robust second wave statistical statistical inference suggested utility variant variants [DOI] 10.1016/j.earlhumdev.2020.105272 PMC 바로가기 [Article Type] Article
Carnosine to Combat Novel Coronavirus (nCoV): Molecular Docking and Modeling to Cocrystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike ProteinArticle Published on 2020-11-282022-10-30 Journal: Molecules [Category] COVID-19, [키워드] ACE1 ACE2 Angiotensin-converting enzyme Angiotensin-converting enzyme 2 (ACE2) approved binding Bioactivity carnosine combat comparable coronavirus coronavirus disease COVID-19 COVID-19 pandemic described docking drug candidate effective element enzyme expected experimental drug higher affinity Host host cells inhibitor inhibitors inhibitory Interaction investigator modeling molecular docking nCoV novel offer performed Practitioner retained SAR similarity spike Spike protein stages starting point [DOI] 10.3390/molecules25235605 PMC 바로가기 [Article Type] Article
Genetic Hypothesis and Pharmacogenetics Side of Renin-Angiotensin-System in COVID-19Hypothesis Published on 2020-09-032022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] ACE1 ACE2 ABO ACE1 ACE2 acute respiratory distress addition affected age ARDS Asia Asians cardiovascular disease caused contribute coronavirus 2 coronavirus disease COVID-19 COVID-19 patient COVID-19 prognosis COVID-19 severity diabete East Ethnic groups Europe European Fatality rate gender-gap Genetic Genetic predisposition GWAS Haplotype host genetics hypertension Hypothesis individual Infection information inhibitor loci locus morbidity and mortality observation outcome pandemic Pandemics pathogenicity pharmacogenetics Predictive Prognosis Prognostic markers raised RAS RAS-pathway receive respiratory rs1978124 rs2285666 rs657152 rs8176719 SARS-1 SARS-CoV-2 side SLC6A20 Spread syndrome the disease Treatment viral infection virus [DOI] 10.3390/genes11091044 PMC 바로가기 [Article Type] Hypothesis
Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: Four hypotheses for possible explanationArticle Published on 2020-08-052023-06-15 Journal: Medical Hypotheses [Category] MERS, [키워드] ACE1 ACE2 Asia COVID-19 Death toll difference Europe Resistance gene mutation SARS-CoV-2 Social behaviors Virulent viruses [DOI] 10.1016/j.mehy.2020.110160 PMC 바로가기 [Article Type] Article
Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)Research Published on 2020-06-252022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] ACE inhibitors ACE1 ACE2 ACE2 binding acute respiratory syndrome animal model antibiotic antiviral agent applied artificial intelligence attenuate benefit binding binding affinity bioinformatics blocking virus entry caused Cell Compound computational approach Computational biology coronavirus Coronaviruses COVID-19 DCT disease-associated drug drug therapy Effect Effects emerging disease Emricasan FDA approved drug Fosamprenavir Gene Expression gene expression pattern global pandemic Glutamine glutathione highlight identify independent induce Infection Patient platform precursor Prevent protective effect Result ruxolitinib SARS-CoV SARS-CoV-2 second specificity technology therapeutic agent TMPRSS2 translation Vitamin E while [DOI] 10.1186/s12967-020-02430-9 PMC 바로가기 [Article Type] Research
The Network of Angiotensin Receptors in Breast CancerReview Published on 2020-05-272022-10-31 Journal: Cells [Category] COVID-19, [키워드] ACE1 ACE2 acute respiratory syndrome Analysis angiotensin AT1R AT2R Breast Breast cancer Cancer candesartan component Compound coronavirus COVID-19 disease different disease Disruption drug target drugs Effect Endocrine expressed G-protein hormone human physiology identify immune system knowledge losartan MasR molecular MRGD multifactorial network offer pathology pathway Pathways produced proliferative Protein RAS receptor renin-angiotensin system Signaling transmembrane Treatment [DOI] 10.3390/cells9061336 PMC 바로가기 [Article Type] Review