Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients코로나19 환자에서 ACE2, 가용성 ACE2, 안지오텐신 I, 안지오텐신 II 및 안지오텐신-(1-7)의 발현이 조절됨Immunology Published on 2021-06-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] ACE2 ACE2 (Angiotensin Converting Enzyme-2) ACE2 expression ACE2 gene ACE2 mRNA ACE2 protein adverse effect adverse effects Affect alveolar Ang II angiotensin angiotensin I Angiotensin II binding blood cell Blood cells blood pressure blood pressure homeostasis Cell cell types cells circulating Concentration consequence coronavirus COVID-19 COVID-19 patient COVID-19 patients dysregulation enzyme etiological agent Evidence Express expression healthy controls healthy volunteers hypertension less lower expression membrane Monocytes outcome plasma plasma concentration Plasma levels pneumocyte Prevent proteolysis regulator Renin – Angiotensin – Aldosterone System sACE2 SARS – CoV – 2 SARS-CoV-2 SARS-CoV-2-infected patients soluble ACE2 the SARS-CoV-2 These data Trigger Variation variations Viral virus [DOI] 10.3389/fimmu.2021.625732 PMC 바로가기 [Article Type] Immunology
Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients중증 코로나19와 중증 환자의 세균성 패혈증 사이의 신장 조직병리 및 유전자 발현 프로파일 비교Research Published on 2021-06-102022-09-11 Journal: Critical Care [Category] MERS, 유전자 메커니즘, 치료제, [키워드] ACE2 mRNA Activation Acute kidney injury acute tubular necrosis AKI AKI patient Analysis angiopoietin Bacterial Bacterial sepsis biopsy cadherin CD31 Cohort collected Control tissue controls COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient death detect determine disease onset downregulated driving endothelial endothelial integrity Extensive feature Fold change gene expression profile histopathological Histopathology ICU ICU admission individual Inflammation Injury involved kidney lack lung tissue marker mechanism Microvascular thrombosis mRNA mRNA expression mRNA level mRNA levels normal not differ observation pathophysiological Patient patients patients with COVID-19 PCR positive peritubular renal renal tissue required Result SARS-CoV-2 RNA Sepsis severe COVID-19 supplementary material the timing thrombi thrombosis tissue total nephrectomy Tubular Necrosis VE-cadherin was obtained [DOI] 10.1186/s13054-021-03631-4 PMC 바로가기 [Article Type] Research
Hypoxia induces expression of angiotensin‐converting enzyme II in alveolar epithelial cells: Implications for the pathogenesis of acute lung injury in COVID‐19Original Article Published on 2021-05-152022-10-28 Journal: Physiological Reports [Category] COVID-19, [키워드] 24 hour ACE2 ACE2 expression ACE2 mRNA acute lung injury acute respiratory distress AEC airway epithelial cell alveolar alveolar epithelial cell alveolar epithelial cells ARDS binding Cell Characteristics Course COVID‐19 Critical Culture dependent on develop distal enzyme II epithelial experiment expression facilitate Features FiO2 host cell surface host serine protease hypoxia hypoxic hypoxic environment in vitro in vivo increase in increased expression induce Isolation lung lung epithelial cell mechanism mice mRNA murine murine model normoxia Pathogenesis Patient progression Protein protein expression proteolytic cleavage purified reduced SARS‐CoV‐2 significantly increased Spike protein Stress subset syndrome TMPRSS2 type I viral spike protein [DOI] 10.14814/phy2.14854 PMC 바로가기 [Article Type] Original Article
Expression of the SARS-CoV-2 receptorACE2 in human heart is associated with uncontrolled diabetes, obesity, and activation of the renin angiotensin systemOriginal Investigation Published on 2021-04-272022-10-31 Journal: Cardiovascular Diabetology [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression ACE2 gene ACE2 mRNA Activation ADAM10 ADAM17 Angiotensin II angiotensin receptor blocker angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 receptor (ACE2) ARB ARBs ATII biopsies biopsy BMI body mass index clinical risk collected complex Corona virus 2 (SARS-CoV-2) correlated Degradation diabete diabetes Diabetic differentially expressed drug Ejection fraction entry of SARS-CoV-2 enzyme expressed expression facilitate Factor glycosylated heart heart tissue hearts hemoglobin higher risk human serum increase Infection infections infused inhibitor Injury investigated medication metformin mice no correlation obese patient obesity Patient plasma positively correlated protein expression RAS receptor Renin–angiotensin system blockers Result right SARS-CoV-2 serine protease serum severe disease Severe infection Support susceptibility tested the SARS-CoV-2 Therapies tissue TMPRSS2 treated Treatment virus was increased [DOI] 10.1186/s12933-021-01275-w PMC 바로가기 [Article Type] Original Investigation
SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19안드로겐과다증 암컷 마우스의 SARS-CoV-2 바이러스 진입 단백질: PCOS 및 COVID-19가 있는 여성에게 미치는 영향Article Published on 2021-04-252022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein ADAM ADAM17 Affect androgen Androgen receptor androgens angiotensin angiotensin I angiotensin I converting enzyme 2 Body body composition body weight Brain cardiometabolic cathepsin cathepsin L causative agent cecum characterized Comorbidities COVID-19 COVID-19 pathology determined by Dihydrotestosterone disorder downregulated dysfunction elevated ELISA Endocrine enzyme fasting fasting glucose fat furin Glucose heart highlight host cell host cells host proteases hyperandrogenism infect kidney lean mass lung male mass mice morphology Mortality mRNA multiple tissue multiple tissues obesity organ systems ovarian Ovary ovulatory pathology Patient Polycystic polycystic ovary Polycystic ovary syndrome priming protease proteases Tmprss2 Protein protein level protein levels qPCR quantified receptor regulate renal risk risk factor Risk factors RT-qPCR SARS-CoV-2 SARS-CoV-2 entry serum severe COVID-19 severity small intestine tissues TMPRSS2 TMPRSS4 treated Treatment upregulated Urine was determined was measured Western-blot with COVID-19 women [DOI] 10.3390/ijms22094472 PMC 바로가기 [Article Type] Article
L-Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-CoV-2 InfectionArticle Published on 2021-04-142022-10-04 Journal: Nutrients [Category] MERS, SARS, 신약개발, [키워드] ACE-2 ACE2 ACE2 mRNA acute respiratory syndrome angiotensin-converting enzyme 2 Calu-3 cleavage coronavirus COVID-19 dose-dependent inhibition drug epithelial cells evaluated exercise expression levels Factors furin Host Human human lung Infection Inflammation L-carnitine limit Pandemics priming protease responsible rodent S-protein SARS-CoV-2 SARS-COV-2 infection serine 2 significant decrease Tartrate tested TMPRSS2 transmembrane Treatment treatment strategy Trial Vaccines viral spike [DOI] 10.3390/nu13041297 PMC 바로가기 [Article Type] Article
Degradation of SARS-CoV-2 receptor ACE2 by the E3 ubiquitin ligase Skp2 in lung epithelial cells폐 상피 세포에서 E3 유비퀴틴 리가제 Skp2에 의한 SARS-CoV-2 수용체 ACE2의 분해Article Published on 2021-04-012022-09-12 Journal: Frontiers of medicine [Category] MERS, SARS, 진단, [키워드] ACE2 ACE2 mRNA ACE2 protein Adults Aryl hydrocarbon receptor benzo(a)pyrene Cancer carcinogen cells COVID-19 pandemic CSE death determine downregulate E3 ligase E3 ubiquitin ligase Hospitalized induce Infection inhibit SARS-CoV-2 lung epithelial cell lung tissue mice observation pseudovirion SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Skp2 smoker Smokers smoking Spike protein Tobacco tobacco smoke. upregulation urgent investigation [DOI] 10.1007/s11684-021-0837-6 PMC 바로가기 [Article Type] Article
Epidemiological Study of Betacoronaviruses in Captive Malayan PangolinsMicrobiology Published on 2021-03-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 ACE2 mRNA acute respiratory syndrome affected angiotensin-converting enzyme 2 bat Betacoronavirus carried cause China coronavirus coronavirus disease CoV COVID-19 dead eight Epidemiology expression Guangdong highest Host individual Infection international public health investigated kidney Malayan pangolin Occurrence organ outbreak pangolin pangolins pathogen Phylogenetic analysis positive rate reported risk SARS-CoV-2 significantly viral control β-CoV [DOI] 10.3389/fmicb.2021.657439 PMC 바로가기 [Article Type] Microbiology
Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyomaCovid-19 Article Published on 2021-03-012022-10-30 Journal: Journal of Endometriosis and Pelvic Pain Disorders [Category] COVID-19, [키워드] ACE2 ACE2 mRNA ACE2 protein acute respiratory syndrome age analyzed Cell cellular receptor coronavirus COVID-19 distribution endothelial cells enzyme evaluated Express expressed Extracellular matrix fibroid Human immunohistochemistry immunoreactivity median mRNA myomectomy myometrium PCR Protein real time reproductive Sample SARS-CoV-2 smooth muscle cell staining surface receptor the SARS-CoV-2 tissue tissues uterine uterine leiomyoma variety Vascular endothelium women [DOI] 10.1177/2284026520954068 PMC 바로가기 [Article Type] Covid-19 Article
Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2Pharmacology Published on 2020-12-172022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] (+)-catechin 4 293T cells ACE2 ACE2 mRNA addition adverse effects Caco-2 cell candidate Compound coronavirus disease cytotoxicity decrease expression Glycyrrhiza uralensis HepG2 cells in vitro in vivo inhibit inhibiting investigated kidney tissue lung occurred Potential Prophylaxis protein expression SARS-CoV-2 SARS-COV-2 infection Simultaneous spread to Taiwan Temple theaflavin theaflavin 3-gallate Tian TMPRSS TMPRSS2 TMPRSS2 expression TMPRSS2 expression level TMPRSS2 protein Treatment Wuhan [DOI] 10.3389/fphar.2020.584158 PMC 바로가기 [Article Type] Pharmacology