ACE2 protein – Page 3 – Communicable Diseases Research

Hydroxychloroquine treatment on SARS-CoV-2 receptor ACE2, TMPRSS2 and NRP1 expression in human primary pterygium and conjunctival cells

인간의 일차 익상편 및 결막 세포에서 SARS-CoV-2 수용체 ACE2, TMPRSS2 및 NRP1 발현에 대한 히드록시클로로퀸 치료

Multicenter Study

Published on 2022-01-012022-09-11
Journal: Experimental eye research [Category] SARS, 바이오마커,

Sex differences in the lung ACE/ACE2 balance in hypertensive rats

Cardiovascular System & Vascular Biology

Published on 2021-12-222022-10-28
Journal: Bioscience Reports [Category] COVID-19,

[키워드] accelerate ACE ACE2 ACE2 gene ACE2 mRNA ACE2 protein Ang II Angiotensin II Angiotensin-(1-7) Angiotensin-converting enzyme angiotensin-converting enzyme 2 blood pressure coexpressed Concentration conducted coronavirus disease COVID-19 down-regulation evaluated expression female four group Genotype-Tissue Expression project Human hypertension hypertensive hypertensive patient Hypothesis lung Lung injury Lungs male Male sex mRNA level normotensive occur pathway promote Protein reduced respiratory infections sexual dimorphism significantly higher subjects tested tissue damage tissues
[DOI] 10.1042/BSR20211201 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology

Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression

Article

Published on 2021-12-222022-10-31
Journal: Cells [Category] COVID-19, SARS,

Differential expression in humans of the viral entry receptor ACE2 compared with the short delta ACE2 isoform lacking SARS-CoV-2 binding sites

Article

Published on 2021-12-212022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 protein airway epithelia Amino acid antibody bind binding binding site cardiovascular system COVID-19 COVID-19 pandemic differential expression domain epithelia Evidence expression Extracellular full-length Health high affinity host cell Human human coronaviruses human tissue implicated Infection inter-individual isoform kidney likelihood liver lung Medical research membrane protein monomer predicted provide receptor receptor ACE2 reduced regulate SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 susceptibility sequence severity staining subsequent susceptibility the spike protein tissues Translational research Variation viral entry viral infection
[DOI] 10.1038/s41598-021-03731-9 PMC 바로가기 [Article Type] Article

Soluble Human Angiotensin- Converting Enzyme 2 as a Potential Therapeutic Tool for COVID-19 is Produced at High Levels In Nicotiana benthamiana Plant With Potent Anti-SARS-CoV-2 Activity

Plant Science

Published on 2021-12-062022-10-31
Journal: Frontiers in Plant Science [Category] COVID-19,

[키워드] ACE2 ACE2 protein activity acute respiratory syndrome angiotensin Anti-SARS-CoV-2 Activity antiviral drug calculated candidate caused coronavirus coronavirus disease country COVID-19 demonstrated enzyme form global public health glycosylated glycosylated form high risk Human IC50 in vitro incubated Infection inhibitory concentration Level Ni-NTA Nicotiana benthamiana pandemic patients with COVID-19 plant plant transient expression potent Potential produced purification receptor Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 vaccine soluble ACE2 Spike protein spread to temperature the SARS-CoV-2 therapeutic therapeutic agent Treatment
[DOI] 10.3389/fpls.2021.742875 PMC 바로가기 [Article Type] Plant Science

Codon usage, phylogeny and binding energy estimation predict the evolution of SARS-CoV-2

Short Communication

Published on 2021-11-242022-10-28
Journal: One Health [Category] COVID-19,

[키워드] Abstract ACE2 ACE2 phylogeny ACE2 protein ACE2 receptor Alpha Amino acid Analysis Animal host B.1.1.7 B.1.1.7 (alpha) SARS-CoV-2 variant B.1.351 (Beta) SARS-CoV-2 variant B.1.351 B.1.617.2 B.1.617.2 (delta) SARS-CoV-2 variant binding binding energy calculated caused codon codon usage Codons D614G mutation docking Evolution Evolution of SARS-CoV-2 Frame functional highlight Human humans Image Infection molecular molecular evolution Mutation not affect observation one health Phylogenetic Phylogeny predict prevalent Protein reveal SARS-CoV-2 SARS-CoV-2 mutation second susceptibility the Spike the spike protein variant variants viral spike protein viral variant virus
[DOI] 10.1016/j.onehlt.2021.100352 PMC 바로가기 [Article Type] Short Communication

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus viruses zoonotic origin
[DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

Article

Published on 2021-11-122022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘,

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Original Paper

Published on 2021-10-292022-10-27
Journal: Angiogenesis [Category] COVID-19,

[키워드] ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Anti-viral anti-viral cytokine binding caused Cell characterized circulating pro-inflammatory cytokines Coagulopathy Complication conditions coronavirus COVID-19 cultures cytokine dependent on described died elevated endothelial Endothelial cell endothelial damage expression facilitate facilitated fatal COVID-19 heterogeneous hyperinflammatory state IFNα individual Infection interferon interferon response interferon-alpha lung mechanism naïve occur Patient patients with COVID-19 pulmonary endothelial cell Pulmonary endothelium raising receptor ACE2 respiratory epithelium SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 significantly subsequent supplementary material the SARS-CoV-2 Thromboembolism Treatment Vascular vasculature Vasculitis Viral pneumonia
[DOI] 10.1007/s10456-021-09823-4 PMC 바로가기 [Article Type] Original Paper

Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2

Original Paper

Published on 2021-10-292022-10-27
Journal: Angiogenesis [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS,

[키워드] ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Anti-viral anti-viral cytokine binding caused Cell characterized circulating pro-inflammatory cytokines Coagulopathy Complication conditions coronavirus COVID-19 cultures cytokine dependent on described died elevated endothelial Endothelial cell endothelial damage expression facilitate facilitated fatal COVID-19 heterogeneous hyperinflammatory state IFNα individual Infection interferon interferon response interferon-alpha lung mechanism naïve occur Patient patients with COVID-19 pulmonary endothelial cell Pulmonary endothelium raising receptor ACE2 respiratory epithelium SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 significantly subsequent supplementary material the SARS-CoV-2 Thromboembolism Treatment Vascular vasculature Vasculitis Viral pneumonia
[DOI] 10.1007/s10456-021-09823-4 PMC 바로가기 [Article Type] Original Paper