COVID-19 Convalescent Plasma Is More than Neutralizing Antibodies: A Narrative Review of Potential Beneficial and Detrimental Co-FactorsCOVID-19 회복기 혈장은 중화 항체 이상입니다 : 잠재적 인 유익하고 유해한 공동 요인에 대한 이야기 검토Review Published on 2021-08-112022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ADAMTS13 Alpha antibody affinity antithrombin III ARMS autoantibodies causal link CCP CCP therapy characterized Clinical efficacy component contribute controlled trials convalescent plasma COVID-19 COVID-19 convalescent plasma decoy receptors detrimental Effect Extracellular vesicles Factor fresh frozen plasma frozen plasma heterologous immunity highlight interferons MDA5 narrative Neutralizing antibodies neutralizing antibody outcome patients with COVID-19 plasma Potential Prophylaxis randomized clinical trial randomized clinical trials reported retrospective review Safe specific antibodies thrombosis Treatment variations [DOI] 10.3390/v13081594 PMC 바로가기 [Article Type] Review
COVID 19 infection associated with thrombotic thrombocytopenic purpura혈전성 혈소판 감소성 자반병과 관련된 코로나19 감염Case Reports Published on 2021-08-012022-09-12 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, SARS, 진단, [키워드] ADAMTS13 Admission association caused cleaving COVID COVID 19 deficiency diagnosed discharged example female Infection injection maintain management Mortality Patient plasma Platelet positive protease purpura rituximab Specific Therapeutic plasma exchange thrombosis thrombotic Thrombotic thrombocytopenic purpura TPE Vincristine in TTP. vWF weakness [DOI] 10.1007/s11239-021-02452-0 PMC 바로가기 [Article Type] Case Reports
Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19COVID-19 환자의 임상 중증도 마커로서의 폰 빌레브란트 인자 및 ADAMTS13 활성Article Published on 2021-08-012022-09-11 Journal: Journal of Thrombosis and Thrombolysis [Category] MERS, SARS, 바이오마커, [키워드] ADAMTS13 age and gender Antigen clinical outcomes Clinical severity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 outpatient COVID-19 outpatients COVID-19 patient COVID-19 patients D-dimer diagnosed disease severity Endothelial dysfunction endothelial injury enrolled evaluate fibrinogen healthy individual highest hypercoagulability ICU patient ICU Patients Imbalance increase increase in Inpatient Inpatients intensive care intensive care unit lead lowest marker mechanism Medical conditions Non-COVID-19 Patient patients with COVID-19 plasma predict Prospective Study prothrombotic state recruited reduction reduction in thrombotic thrombotic risk von Willebrand factor vWF were measured with COVID-19 [DOI] 10.1007/s11239-021-02457-9 PMC 바로가기 [Article Type] Article
Von Willebrand factor collagen-binding capacity predicts in-hospital mortality in COVID-19 patients: insight from VWF/ADAMTS13 ratio imbalance폰 빌레브란트 인자 콜라겐 결합 능력은 COVID-19 환자의 병원 내 사망률을 예측합니다: VWF/ADAMTS13 비율 불균형으로부터의 통찰력Article Published on 2021-08-012022-09-11 Journal: Angiogenesis [Category] SARS, 바이오마커, [키워드] 48 hour 48 hours 95% CI ADAMTS13 adjusted Admission Analysis AUC balance best Biomarker BMI C-reactive protein collagen Collagen-binding COVID-19 COVID-19 severity Critical cut-off D-dimer levels described enrolled hallmark hazard Hospital mortality hospitalized COVID-19 patient in-hospital mortality IQR Kaplan-Meier estimator median Microthrombosis molecular weight Mortality Multimers Patient Plasma level Plasma levels predict Predictive ROC Curve shown significantly subsequent Trigger von Willebrand factor vWF was increased were measured [DOI] 10.1007/s10456-021-09789-3 PMC 바로가기 [Article Type] Article
Predictive Role of Haematological Determinants on Outcomes of Critically Ill COVID-19 Patients Admitted to Intensive Care UnitEmergency Medicine Published on 2021-07-302022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abnormality acquired von willebrand Acute kidney injury acute kidney injury care ADAMTS13 admitted to ICU AKI alveolar damage Antigen Coagulation Combination COVID 19 COVID-19 COVID-19 patient cross-sectional D dimer D-dimer defined determinant determine disease severity evaluate extra-pulmonary organs factor VIII feature Hypoxemia hypoxic respiratory failure ICU Ill increases in intensive care intensive care unit intensive respiratory care invasive marker mechanical ventilation microthrombi Mortality multi-organ dysfunction Non-invasive outcome Patient peak peak D-dimer Pneumonia raised reference ranges required risk role SARS-CoV-2 positive patient severe COVID-19 patient Severe COVID-19 pneumonia severity significantly Thromboembolism thrombotic Vascular vasoconstriction was obtained with COVID-19 [DOI] 10.7759/cureus.16764 PMC 바로가기 [Article Type] Emergency Medicine
ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathyObservational Study Published on 2021-07-012022-10-05 Journal: International journal of laboratory hematology [Category] SARS, 임상, [키워드] acute kidney Acute kidney injury ADAMTS13 adult COVID-19 patient age AKI Antigen association Coagulopathy Cohort conducted confounders correlated COVID-19 COVID-19 severity criteria deficiency defined Disease progression elevated enrolled evaluate evidence of hemoglobin hospitalized patient increase in KDIGO LDH outcome outcomes Patient patients with COVID-19 positively correlated predict presenting primary endpoint progression prothrombotic state SARS-CoV-2 secondary endpoint severe COVID-19 disease significantly lower thrombosis thrombotic von Willebrand factor were measured with COVID-19 [DOI] 10.1111/ijlh.13415 PMC 바로가기 [Article Type] Observational Study
Immune Thrombotic Thrombocytopenic Purpura in a Patient with Suspected COVID-19: Hydroxychloroquine Culprit or Just Happenstance?Letters to the Editor Published on 2021-06-012022-10-28 Journal: Turkish Journal of Hematology [Category] Coronavirus, SARS, [키워드] ADAMTS13 COVID-19-induced iTTP Hydoxychloroquineinduced TTP Suspected thrombotic microangiopathy von Willebrand factor [DOI] 10.4274/tjh.galenos.2021.2021.0057 PMC 바로가기 [Article Type] Letters to the Editor
Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA2019년 코로나바이러스 질병(COVID-19)에서 조절되지 않는 염증성, 혈전성, 항섬유소용해 상태 및 심각한 급성 신장 손상의 발달과 관련된 지질 프로필의 변화: 미국 신시내티의 연구Article Published on 2021-05-012022-09-11 Journal: Diabetes & metabolic syndrome [Category] SARS, 바이오마커, [키워드] Acute kidney injury ADAMTS13 AKI alteration analyzed Apolipoprotein Apolipoproteins association Biomarkers Cincinnati Control coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 cohort COVID-19 patient COVID-19 patients creatinine CRP decrease Department Deterioration dietetics disease driven by dysregulated Emergency emergency department Hospitalization Hypolipidemia ICU admission IL-10 IL-6 IL-8 immunothrombosis independent Inflammatory Inflammatory biomarker kidney LDL-C Lipid lipoprotein Lipoproteins multiorgan injury nutritional interventions observational study outcome Patient patients plasminogen Predictive presenting Primary outcome profile prospective observational study prothrombotic renal Secondary outcomes serum serum creatinine sick significantly lower thrombotic thrombotic microangiopathy USA were measured [DOI] 10.1016/j.dsx.2021.04.011 PMC 바로가기 [Article Type] Article
Genetic justification of severe COVID-19 using a rigorous algorithm엄격한 알고리즘을 사용한 중증 코로나19의 유전적 정당화Article Published on 2021-05-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] 변종, [키워드] Activation ADAMTS13 Algorithm analyzed benefit Characteristics Clinical data Combination complement Complement activation complement inhibitors coronavirus disease Coronavirus disease-19 COVID-19 disease severity eculizumab Gender Genetic genetic susceptibility highlight Hospitalization ICU Patient patient population patients patients hospitalized recent Rigorous algorithm risk factor SARS-CoV2 severe coronavirus disease severe COVID-19 specific treatment thrombomodulin thrombotic thrombotic microangiopathy variant variants [DOI] 10.1016/j.clim.2021.108726 PMC 바로가기 [Article Type] Article
COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and ManagementArticle Published on 2021-04-022023-06-16 Journal: Shock (Augusta, Ga.) [Category] MERS, [키워드] a disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 ADAMTS13 CFT clot formation time Coagulation coronavirus coronavirus disease-2019 COVID-19 ECMO Embolism extracorporeal membrane oxygenation ICU IL intensive care unit interleukin Jak Janus kinase k kinetic time MA MAPK maximum amplitude maximum clot firmness MCF mitogen-activated protein kinase PAI-1 PGI2 Plasminogen activator inhibitor-1 prostacyclin SARS-CoV-2 severe acute respiratory syndrome coronavirus-2 TEG TEM thromboelastography Thromboelastometry thrombosis TNF tumor necrosis factor ultra-large von Willebrand factor ULVWF Venous Thromboembolism VTE [DOI] 10.1097/SHK.0000000000001660 PMC 바로가기