Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail코로나19 꼬리를 통한 근위축성 측삭경화증 환자 관리 원격진료Review Published on 2020-10-062022-09-12 Journal: Neurological Sciences [Category] MERS, 진단, [키워드] affected ALS ALS patients Amyotrophic lateral sclerosis Complete conditions Containment measure containment measures coronavirus coronavirus disease COVID-19 COVID-19 patients creation Disease progression Focusing Follow-up Healthcare systems higher risk IMPROVE Lateral Sclerosis life-threatening management MONITOR morbidity morbidity and mortality Neurological diseases over pandemic Patient patients remote monitoring resource risk Tele-health Telemedicine Teleneurology [DOI] 10.1007/s10072-020-04783-x PMC 바로가기 [Article Type] Review
Grand rounds: a precious resource to be nurtured그랜드 라운드: 소중한 자원으로 보살펴야 할 것Editorial Published on 2020-10-012023-06-01 Journal: Practical neurology [Category] 대상포진, 두창, 수두, 홍역, [키워드] AIDS ALS Borrelia herpes zoster Infectious diseases Medicine motor neuron disease MRI PET. [DOI] 10.1136/practneurol-2020-002626 [Article Type] Editorial
Hypoxemia Index Associated with Prehospital Intubation in COVID-19 PatientsArticle Published on 2020-09-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval adjusted odds ratio age ALS Analysis analyzed association AUC bivariate analysis Brigade Care characteristic confounders COVID-19 COVID-19 patient COVID-19 patients Deceased defined demonstrated expressed facilitate fire Hypoxemia increase in index Intubated intubation investigated Logistic regression analysis logistic regression model male multivariate Odds ratio Paris Patient patients prehospital prognostic propensity score matching Prospective Study Result ROC ROC Curve significantly Support threshold [DOI] 10.3390/jcm9093025 PMC 바로가기 [Article Type] Article
Triage of Amyotrophic Lateral Sclerosis Patients during the COVID-19 Pandemic: An Application of the D50 ModelArticle Published on 2020-09-052022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] aggressiveness ALS Amyotrophic lateral sclerosis application assisted ventilation Care caused comparable Contact COVID-19 COVID-19 outbreak D50 disease Disease progression effort Follow-up gastrostomy high-risk patient identify initiated Lateral Sclerosis maintain management Metrics Model neuromuscular disease non-invasive ventilation novel coronavirus disease offered pandemic Patient Patient care patients prospective cohort retrospective cohort risk SARS-CoV-2 supportive therapies Therapies Triage [DOI] 10.3390/jcm9092873 PMC 바로가기 [Article Type] Article
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosisResearch paper Published on 2020-08-302022-11-01 Journal: EBioMedicine [Category] Coronavirus, SARS, [키워드] affecting aggregation ALS Amyotrophic lateral sclerosis approved cause Compound COVID-19 cysteine demonstrated develop disease disease onset dominant drug drug design Ebselen education enzyme finding funding gene encoding improvement in vitro involved Japan ligand-bound Lou Gehrig mice motor neuron motor neuron disease mutant Mutation neurodegeneration Neurological disorder neuronal cell novel offer pathogenic performed Prevent protease Riluzole Science significantly SOD1 sports stability Structure supported technology the disease therapeutic therapeutic benefits Therapeutic compounds therapeutic effect therapeutic potential these compound Toxicity transgenic Treatment utilised viral disease wild-type [DOI] 10.1016/j.ebiom.2020.102980 PMC 바로가기 [Article Type] Research paper
Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies새로운 효모 단백병증 모델 및 유전자 변형 파리에서 PBP1/ATXN2 기능의 손실에 의해 칼슘 반응성 트랜스활성제(CREST) 독성이 구출됩니다Research Article Published on 2019-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Affect aggregate aggregation ALS Amyotrophic lateral sclerosis ATXN2 calcium caused chaperone CREST cytoplasmic degenerative Deletion disease Disease model Diseases downregulation Drosophila effective enhancer expressed facilitate foci form ganglion cell ganglion cells Genes inhibit Lateral Sclerosis Like Localization mammalian cells mechanism modify Mutation neurodegenerative neurons nuclear ortholog overexpressing overexpression phenotype Propagation Protein Proteins reduce reduced regulated required rescued risk factor shown Spectrum SS18L1 targets therapeutic target therapy Thioflavin toxic Toxicity transgenic yeast yeast form yeast forms [DOI] 10.1371/journal.pgen.1008308 PMC 바로가기 [Article Type] Research Article
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSRetrotransposon 활성화는 ALS의 Drosophila TDP-43 모델에서 신경 퇴행에 기여합니다Research Article Published on 2017-03-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality accompanied Activation aggregation ALS Amyotrophic lateral sclerosis Author cascade cause cell death cell types cells Characteristics contribute cytoplasmic de-repression death degeneration degenerative disease DNA DNA binding protein DNA damage Drosophila Effect Effects element event Evidence expressed expression Familial Genetic Genome Glia glial cells hallmark human disease impair impairment Inclusion incurable inhibiting Lateral Sclerosis lobar locomotor LTR majority mechanism Mutation neurodegeneration neurodegenerative disorder neurodegenerative disorders Neuron neuronal neurons nuclear protein pathology pathophysiological phenotype phenotypic Premature programmed cell death PROTECT Protein repression retrotransposon retrotransposons retrovirus reverse transcriptase RNA RNA silencing siRNA Small interfering RNA storm subset the disease tissue Toxicity transcriptase [DOI] 10.1371/journal.pgen.1006635 PMC 바로가기 [Article Type] Research Article
Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegansCaenorhabditis elegans의 소포 수송에 의한 세포 간 프리온 도메인의 확산Research Article Published on 2013-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregation ALS amyloid Amyotrophic lateral sclerosis animal model appearance asparagine Author autonomous autophagy Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans Cell cellular cellular pathway conformation culture cell cytosolic Degradation developmental delay different disease Diseases domain elegan embryonic Encephalopathy Epigenetic Evidence exhibit expressed expressing expression form Glutamine hallmark hallmarks include infect infectious Lateral Sclerosis lobar lysosomal lysosomal vesicle mechanism misfolded protein misfolded proteins mitochondrial multicellular multicellular organism N-terminus naive cells neurodegenerative neurodegenerative disorders NM organism Parkinson's Disease pathology pathway prion Propagation Protein Proteins real time recent Spread spreading thought tissue tissue culture tissues Toxicity trait transgenic mice transmissible spongiform encephalopathies Transmission Transport underlie Vesicle vesicular widespread yeast [DOI] 10.1371/journal.pgen.1003351 PMC 바로가기 [Article Type] Research Article