Whole lung lavage: Treating pulmonary alveolar proteinosis at the time of COVID pandemicCase report Published on 2022-07-142022-10-05 Journal: Respiratory Medicine Case Reports [Category] 유전자 메커니즘, [키워드] alveolar clearance COVID COVID-19 disease dropped exacerbated hypoxemic lung lung lavage magnitude pandemic Patient Pneumonia pulmonary Pulmonary alveolar proteinosis syndrome the disease treating Treatment Viral load Whole pulmonary lavage [DOI] 10.1016/j.rmcr.2022.101707 [Article Type] Case report
Response to PEEP in COVID-19 ARDS patients with and without extracorporeal membrane oxygenation. A multicenter case-control computed tomography studyObservational Study Published on 2022-07-022022-10-04 Journal: Critical Care [Category] 임상, [키워드] adverse effect alveolar appear ARDS ARDS patients benefit Case-control case-control study Computed tomography conducted COVID-19 COVID-19 ARDS patient ECMO extracorporeal membrane oxygenation fraction greater logarithm lung lung collapse Lung recruitability median moderate multicenter not significantly different Patient patients PEEP PEEP. Pneumonia Recruitability recruitment required response severe ARDS severe COVID-19 patient significantly significantly higher significantly lower Total variations [DOI] 10.1186/s13054-022-04076-z PMC 바로가기 [Article Type] Observational Study
Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infectionGS-441524의 정맥내 전달은 SARS-CoV-2 감염의 아프리카 녹색 원숭이 모델에서 효과적입니다Article Published on 2022-07-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration African African green monkey African green monkeys AGM AGMs alveolar antiviral activity antiviral efficacy antiviral therapy approved assays causative agent coronavirus COVID-19 COVID-19 pandemic determine dose dose-dependent efficacy dosed exhibit FDA green green monkey GS-441524 in vitro in vivo intravenous less Lower respiratory tract lung nucleoside oral bioavailability parent nucleoside plasma plasma concentration plasma concentrations potential therapies potential therapy primary cells RDV reduced reduction Remdesivir required respiratory virus respiratory viruses resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant reductions significantly higher Support treated Treatment treatment of COVID-19 triphosphate [DOI] 10.1016/j.antiviral.2022.105329 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways인간 유도 만능 줄기 세포 유래 폐 계통 세포의 SARS-CoV-2 감염은 미토콘드리아 경로를 표적으로 하여 염증 및 화학 감각 반응을 유발합니다Article Published on 2022-07-012022-09-12 Journal: Journal of cellular physiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome addition Affect airway alveolar alveolar cells Antiviral Apoptosis caused Cell cells chemosensory chemosensory response complexes Consequences coronavirus COVID-19 COVID-19 disease COVID-19 patients Defense developmental distal dysregulation epithelial HMOX1 IL-13 IL-6 immune responses in viral in vitro Increased induced pluripotent stem cells INF-γ infected cell Inflammatory Inflammatory response Lineage lung lung epithelial Lung epithelial cells Lung injury lung tissue maturation mechanism metabolic processe mitochondrial mitochondrial damage. pathway precursor Proinflammatory cytokine proximal replicated response resulting robust ROS ROS production SARS-CoV-2 SARS-COV-2 infection spatiotemporal therapeutic drug TNF-α transcriptomics Transport upregulated upregulation [DOI] 10.1002/jcp.30755 PMC 바로가기 [Article Type] Article
Pulmonary lesions induced by SARS-CoV-2 infection in domestic cats집고양이에서 SARS-CoV-2 감염으로 유발된 폐 병변Article Published on 2022-07-012022-09-11 Journal: Veterinary pathology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus affected alveolar alveolar fibrin B and T lymphocytes Blood blood vessel bronchiolar Bronchiolitis cat cats Chain Reaction consolidation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease DPI Endothelium epithelial expression fatal disease FIBRIN fibrosis histologic Histopathology hypertrophy immunohistochemistry in some individuals Infection interstitial pneumonia lesion limit of detection lung Lung disease lung lesion macrophages MHC II Microscopic Mild mild to moderate moderate occlusive patchy Patient Pneumonia polymerase chain polymerase chain reaction proliferation pulmonary pulmonary lesion pulmonary lesions quantitative polymerase chain reaction reactive respiratory signs reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA septal thickening severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T lymphocytes type II pneumocytes vacuolar vacuolar degeneration Vasculitis vessel Viral load viral loads Viral RNA [DOI] 10.1177/03009858211066840 PMC 바로가기 [Article Type] Article
The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney InjurySARS-CoV-2 감염 및 급성 신장 손상에서 비타민 D의 역할Review Published on 2022-07-012022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute kidney Acute kidney injury acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive addition AKI alveolar Anti-inflammatory Anti-inflammatory effects antioxidant benefit broad spectrum calcium Cell cell metabolism Chronic kidney disease CKD contribute Control coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 severity Critically ill Critically ill patient critically ill patients cytokine release deficiency described Effects endothelial damage essential nutrient Genes homeostasis hormone in-hospital mortality Infection influence Innate immunity involved Kidney disease manifestation mechanism metabolism mitochondrial modulation molecular Mortality non-genomic nuclear outcome Pathologies Pathways phosphate proinflammatory recruitment regulate risk role SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe coronavirus disease Side effects targets therapeutic strategy Toxicity Transcription Vitamin Vitamin D vitamin D deficiency vitamin D level vitamin D serum Vitamin D supplementation [DOI] 10.3390/ijms23137368 PMC 바로가기 [Article Type] Review
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice알코올은 폐 안지오텐신 전환 효소 2 발현을 증가시키고 중증 급성 호흡기 증후군을 악화시킨다Article Published on 2022-07-012022-09-11 Journal: The American journal of pathology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alcohol Alcohol Abuse alcohol consumption alveolar Alveolar space angiotensin angiotensin-converting enzyme 2 Biomarker blood cell body weight Bronchoalveolar lavage fluid chronic coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course Cytokine storm decrease dramatic increase enzyme Ethanol Express Factor human ACE2 receptor Human angiotensin-converting enzyme 2 Immune cell immune cells increase Inflammasome Interaction K18-hACE2 lung tissue mechanism mice Mortality NF-κB NLR NLRP3 overexpression pandemic parenchymal proinflammatory protein 3 recruitment reported respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein STAT3 Stress subunit syndrome Therapeutic approach therapeutic approaches transgenic mice White blood cell worsening [DOI] 10.1016/j.ajpath.2022.03.012 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron VariantsACE2 및 TMPRSS2를 발현하는 새로 설계된 A549 세포주는 Delta 및 Omicron 변이체를 포함하여 SARS-CoV-2에 매우 관대합니다.Article Published on 2022-06-232022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] A549 A549 cell A549 cells ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alveolar angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral drug antiviral drugs antivirals breakthrough infections can be used Cell coronavirus Critical Culture Delta delta and omicron variants drugs EIDD-1931 Express expressed expressing Factor Host human ACE2 human cell identify Including Infection infection with SARS-CoV-2 inhibit SARS-CoV-2 lack LINE nelfinavir New Nirmatrelvir omicron Omicron variants Permissive Remdesivir respiratory Respiratory virus infections SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serine severe acute respiratory syndrome Coronavirus Spike protein susceptible the SARS-CoV-2 TMPRSS2 transcript transducing transmembrane serine protease transmembrane serine protease 2 variant Viral viral entry virus infections [DOI] 10.3390/v14071369 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamstersSARS-CoV-2 오미크론 변이체는 햄스터의 상부 및 하부 호흡기에서 가벼운 병리를 유발합니다Article Published on 2022-06-202022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alveolar cause caused changes in Coronavirus-2 Delta Gamma hamster hamsters Infection infectious virus titer infectious virus titers intranasal investigated lesion Lower respiratory tract lung Mild Olfactory epithelium omicron pathogenicity pathological pathology respiratory tissue respiratory tissues rhinitis RNA SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Strains Syrian golden hamster Syrian Golden hamsters upper and lower respiratory tract upper and lower respiratory tracts variant variants variants of concern Viral antigen virus spread VoC VOCs [DOI] 10.1038/s41467-022-31200-y PMC 바로가기 [Article Type] Article