alveolar macrophage – Page 3 – Communicable Diseases Research

Monocytes and Macrophages in COVID-19

COVID-19의 단핵구 및 대식세포

Review

Published on 2021-07-212022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

Modulation of Host Immune Response Is an Alternative Strategy to Combat SARS-CoV-2 Pathogenesis

Immunology

Published on 2021-07-082022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] ACE-2 receptor acting activated alveolar alveolar macrophage caused CD8+ T cell chemokines chemotactic combat complex COVID-19 cytokine Cytokines fusion help high mortality Host host cell Host immune response host immune system infected cells inflammatory mediator kill Local macrophages membrane Modifying Monocytes Neutrophils NK cells pandemic phagocytosis pneumocyte Pneumocytes Protein receptor reduce replicate response RTC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2virus secreting Spike protein Strategy the disease therapeutic targets TMPRSS2 translated type-2 pneumocyte viral life cycle viral membrane Viral RNA virus
[DOI] 10.3389/fimmu.2021.660632 PMC 바로가기 [Article Type] Immunology

Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis

호중구 세포외 트랩은 상피-중간엽 전환을 유도합니다: 코로나19 이후 섬유증에 미치는 영향

Immunology

Published on 2021-06-142022-09-12
Journal: Frontiers in Immunology [Category] MERS, 진단,

Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy

과립구 대식세포 집락 자극 인자가 도래했다: 백신 보조제에서 항바이러스 면역요법까지

Review

Published on 2021-06-012022-09-11
Journal: Cytokine & growth factor reviews [Category] SARS, 치료제,

TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions

Research Paper

Published on 2021-05-252022-10-28
Journal: Theranostics [Category] COVID-19, SARS,

[키워드] activate acute respiratory syndrome alveolar alveolar macrophage approach bovine caused condition conditions contagious coronavirus coronavirus disease Coronavirus-2 Critical cytokine cytokine release Cytokines domain drug target Effect ENhance entry of SARS-CoV-2 enzyme-linked immunosorbent assay evaluate examined febrile Fever Gene Expression genes encoding glutathione human cell humans immunofluorescence infect Inflammatory response Interaction knockdown Macrophage macrophages mouse macrophages NF-κB oligonucleotide p65 performed Plasmid primary bovine alveolar macrophage Prolonged fever promote Protein RBD receptor Regulatory resource RNA S-RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S secretion signaling pathway significantly SKF-96365 spike protein receptor-binding domain staining temperature the SARS-CoV-2 THP-1 transfected with TRPV2 was measured were used
[DOI] 10.7150/thno.58781 PMC 바로가기 [Article Type] Research Paper

Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

SARS-CoV-2 돌연변이에 의한 감염의 게놈 규모 대사 모델은 구아닐레이트 키나아제를 강력한 잠재적 항바이러스 표적으로 확인

Article

Published on 2021-05-242022-09-10
Journal: Genes [Category] SARS, 변종, 치료제,

[키워드] alveolar macrophage Alveolar macrophages Antiviral antiviral target antiviral therapies antiviral therapy Antiviral treatment approval B.1.1.7 B.1.28 B.1.351 B.1.427/B.1.429 B.1.617 Combination COVID-19 COVID-19 patients Efficacy experiment flux balance analysis (FBA) GEM genome-scale metabolic models highlight in viral information Interaction investigated kinase Laboratory lipid metabolism macrophages metabolic metabolism Model mutant Mutation pandemic Perspective Phosphatidylcholine Potential purine purine metabolism pyrimidine pyrimidine metabolism reaction knock-out Replication robust SARS-CoV-2 SARS-CoV-2 pandemic structural protein structural proteins target Target identification targets Vaccine Vaccine development variant variants of SARS-CoV-2 Viral viral replication
[DOI] 10.3390/genes12060796 PMC 바로가기 [Article Type] Article

High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages

초기 인간 항-SARS-CoV-2 IgG의 높은 역가 및 낮은 푸코실화는 폐포 대식세포에 의한 염증을 촉진합니다

Research Article

Published on 2021-05-112022-09-12
Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단,

[키워드] Activation acute respiratory distress acute respiratory distress syndrome Adaptive immune response addition alveolar alveolar macrophage Alveolar macrophages anti-SARS-CoV-2 IgG Anti-spike anti-Spike IgG anti-spike protein IgG antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients cytokine Cytokines dependent on diagnosed disease driven by early phase Evidence excessive inflammatory response Fcγ receptor FcγR FDA feature fostamatinib glycosylation hallmark human macrophage IgG IIa in vitro induce infection with SARS-CoV-2 Inflammation Inflammatory response inhibitor initial interleukin interleukin-6 intrinsically Macrophage macrophage activation macrophages Microvascular thrombosis Necrosis occur Patient pro-inflammatory promote promote inflammation pulmonary endothelial receptor respiratory distress Respiratory distress syndrome responsible SARS-CoV-2 second Seroconversion serum severe COVID-19 severe disease small molecule Spike protein syndrome therapeutic thrombosis Tumor tumor necrosis tumor necrosis factor was normalized worsening
[DOI] 10.1126/scitranslmed.abf8654 PMC 바로가기 [Article Type] Research Article

Single-cell multi-omics analysis of the immune response in COVID-19

COVID-19의 면역 반응에 대한 단일 세포 다중 오믹스 분석

Article

Published on 2021-04-202022-09-10
Journal: Nature Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration alveolar alveolar macrophage Analysis Antigen antigen receptor B lymphocyte blood immune cell blood sample Blood samples C1QA cause CD16 CD34 CD8 Cell cellular component characterized circulating Cohort complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis cross-sectional disease disease severity effector memory effector T cell effector T cells expansion expressing follicular Haematopoiesis helper T cell hematopoietic progenitor cell highlight IgA2 Immune cell immune cells immune response individuals with COVID-19 Infection lymphocyte Macrophage megakaryopoiesis memory T cells Mild Mild disease monocyte Monocytes mononuclear cell mononuclear cells Patient performed Peripheral blood Peripheral blood mononuclear cells Plasma cells plasmablast plasmablasts Platelet platelet activation Platelets predicted proteome proteomic provide receptor reveal RNA sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severity single-cell symptomatic disease T cell T cells therapy transcript Transcriptome Viral viral infection viral infections
[DOI] 10.1038/s41591-021-01329-2 PMC 바로가기 [Article Type] Article

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

Article

Published on 2021-04-132022-10-31
Journal: Cell Discovery [Category] COVID-19,

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?

다낭성 난소 증후군에서 대식세포 유래 사이토카인과 비타민 D 연관성: COVID-19 감염 위험 증가?

Endocrinology

Published on 2021-02-252022-09-11
Journal: Frontiers in Endocrinology [Category] MERS, 바이오마커,

[키워드] accounted alveolar macrophage aptamer basal BMI body mass body mass index both groups CD163 CD200 CD80 change changes in Concentration contribute correlated COVID-19 COVID-19 disease COVID-19 infection COVID-19 risk factors cross-sectional cross-sectional study CXCL5 cytokine Cytokines deficiency determine determined by elevated enhanced Factors greater IFN-γ IL-12 immune response in both group independent infection risk Inflammation Macrophage macrophage activation marker mass spectroscopy MMP9 obese obesity Ovary Plasma level Plasma levels plasma protein Polycystic polycystic ovary polycystic ovary disease Protective pulmonary disease Result risk risk factor severe COVID-19 disease Severe COVID-19 Infection slow stratified syndrome variable Vitamin Vitamin D vitamin D deficiency was measured women
[DOI] 10.3389/fendo.2021.638621 PMC 바로가기 [Article Type] Endocrinology