Extracellular Vesicle Associated miRNAs Regulate Signaling Pathways Involved in COVID-19 Pneumonia and the Progression to Severe Acute Respiratory Corona Virus-2 Syndrome
세포 외 소포 관련 miRNA는 COVID-19 폐렴에 관여하는 신호 전달 경로를 조절하고 심한 급성 호흡기 코로나 바이러스 -2 증후군으로의 진행
Immunology
[키워드] ACE2 expression
activated
adjusted
alveolar cell
among others
Analysis
analyzed
ARDS
ARDS patients
bind
Biomarker
Biomarkers
carrier
carriers
Cell
cell-free microRNAs
cell-to-cell communication
cells
circulating
community acquired pneumonia
controls
Corona
COVID-19
COVID-19 ARDS patient
COVID-19 pneumonia
CXCL8
Differential gene expression
differential gene expression analysis
differentially expressed miRNA
downregulated
epithelial
evaluated
EVs
Extracellular vesicles
function
group
healthy control
healthy controls
IL6
increase
Inflammatory
inhibited
interleukin
interleukin-6
interleukin-8
investigated
let-7e-5p
log2FC
lung
Lung diseases
mechanically ventilated patient
mediators
miR-146
miR-146a-5p
miRNA
miRNAs
mRNA
mRNA transcript
mRNA transcripts
nasal epithelium
network
network analysis
neutrophil
neutrophil recruitment
olfactory
OR52N2
pathophysiology
Pathways
Pneumonia
Precipitation
prospectively studied
receptor
regulate
regulated
respiratory
Result
resulting
RNA sequencing
SARS-CoV-2 spike protein
secrete
Sepsis
Severe Acute Respiratory Corona Virus-2 Syndrome
severe COVID-19
Signaling
signaling pathway
significantly
small RNA
small RNA sequencing
Spike protein
symptomatic patient
syndrome
the healthy
therapeutic targets
TLR4
Toll-like receptor
toll-like receptor 4
total RNA
transcript
upregulated
Vesicle
with COVID-19
[DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2021.784028 PMC 바로가기 [Article Type] Immunology