Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp)Article Published on 2022-01-262022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] absence against SARS-CoV analogue analysed antiviral activity Compound condition docked drug drug candidate drugs effective inhibitor essramycin Favipiravir Genomic variability HCV HIV in vitro in vivo influenza viruses inhibitor inhibitory activity knowledge Meta-analysis molecular molecular docking more difficult mutants non-structural protein non-structural proteins (NSP) novel nsp1 nsp5 NSP8 outbreak performed pharmacological positive control potential therapeutic agent Protein RdRP RdRp protein Remdesivir respiratory RNA RNA polymerase RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) SARS-CoV-2 stability the SARS-CoV-2 triazolopyrimidine Vaccine viral replication virus was performed [DOI] 10.3390/molecules27030801 PMC 바로가기 [Article Type] Article
Nucleotide Analogues Bearing a C2′ or C3′-Stereogenic All-Carbon Quaternary Center as SARS-CoV-2 RdRp Inhibitors †Article Published on 2022-01-172022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] addition analogue Bearing center COVID-19 described epoxidation functional glycosylation inhibitor N -glycosylation NTP nucleoside analogue Nucleoside analogues quaternary stereocenter RdRP reaction Reactions RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp these compound triphosphorylation virus [DOI] 10.3390/molecules27020564 PMC 바로가기 [Article Type] Article
Drugs Used in the Treatment of Multiple Sclerosis During COVID-19 Pandemic: A Critical ViewpointCovid-19 Pandemic 동안 다발성 경화증 치료에 사용되는 약물 : 중요한 관점Article Published on 2022-01-012022-08-31 Journal: Current neuropharmacology [Category] SARS, 치료제, [키워드] Acetate activating acute respiratory distress acute respiratory distress syndrome Alemtuzumab analogue antiviral activity approved ARDS autoimmune disorder Autoimmune disorders caution cellular Cladribine concern COVID-19 COVID-19 infection COVID-19 pandemic cytokine Cytokine storm Defense depleting detrimental dimethyl fumarate disease Disease-modifying therapy drug early stage endothelial example fingolimod fumarate Glatiramer Glatiramer acetate health problem hyperinflammation Hyperinflammatory IFN IFNs immunomodulation interfere interferon Invasion lung Macrophage mechanisms Multiple multiple sclerosis Natalizumab neuroprotection Nrf-2 nucleotide nucleotides Ocrelizumab other organs overcome oxidative stress pathway potential risk Protective public health raised reinforcement respiratory distress risk risk-benefit ratio. Safe SARS-CoV-2 SARS-COV-2 infection sclerosis suggested syndrome Teriflunomide Treatment Viral viral replication [DOI] 10.2174/1570159X19666210330094017 PMC 바로가기 [Article Type] Article
Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2SARS-CoV-2에 대한 천연 약물로서의 세파란틴 유사체 평가Research Article Published on 2021-12-092022-09-10 Journal: FEBS Open Bio [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition alkaloid analogue analogues binding affinities binding affinity Cepharanthine Compound conformation coronavirus coronavirus disease Coronavirus disease 2019 database demonstrated DIPHENYL disease docking drug Drug repurposing drugs Efficacy evaluate evaluated Evaluating humans Infection molecular docking molecules natural drug NPC1 performed predicted protease respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV Spike protein suggested target proteins tetrandrine the spike protein these compound these compounds were assessed [DOI] 10.1002/2211-5463.13337 PMC 바로가기 [Article Type] Research Article
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitroScutellaria baicalensis 추출물 및 Baicalein은 SARS-COV-2 및 그의 3C- 유사 프로테아제의 복제를 시험관 내에서 억제합니다.Article Published on 2021-12-012022-08-31 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] SARS, 치료제, [키워드] 3C-like protease 3CL pro analogue Anti-SARS-CoV-2 Activity baicalein baicalein. broad spectrum Compound Concentration COVID-19 drug Drug discovery drugs Ethanol global pandemic in vitro inhibit inhibit SARS-CoV-2 protease Replication replication of SARS-CoV-2 SARS-CoV SARS-CoV-2 Scutellaria baicalensis Vero Cell Vero cells Viral viral entry virus while [DOI] 10.1080/14756366.2021.1873977 PMC 바로가기 [Article Type] Article
Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual ScreeningArticle Published on 2021-11-302022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] acute respiratory syndrome analogue Antiviral agents antiviral drugs Cell Compound coronavirus cytotoxic effects docking energy transfer Enzymes evade evaluated fluorescent glycine High-throughput virtual screening homogeneous HTRF Human immune system inhibition activity inhibitor inhibitors majority methyltransferase mRNA MTase inhibitors nsp14 nsp16 performed S-adenosylmethionine SAM SARS-CoV-2 Screening Seven starting point target tested the SARS-CoV-2 Virtual screening [DOI] 10.3390/ph14121243 PMC 바로가기 [Article Type] Article
Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63Article Published on 2021-11-112022-10-30 Journal: Molecules [Category] COVID-19, MERS, [키워드] 1,3,8-trihydroxy-6-methylanthracene-9,10-dione activity analogue antiviral activities antiviral activity comparable coronavirus COVID-19 COVID-19 outbreak derivative derivatives drug effective electrophilic emodin generate halogenated emodin HCoV-NL63 human coronavirus human coronavirus NL63 Imatinib IMPROVE initial Modification natural NL63 plant plants reaction Remdesivir respiratory SAR SARS-CoV-2 significantly Toxicity Treatment Vaccine Vero cells Viral diseases [DOI] 10.3390/molecules26226825 PMC 바로가기 [Article Type] Article
Synthesis and characterization of new thiazole-based Co(II) and Cu(II) complexes; therapeutic function of thiazole towards COVID-19 in comparing to current antivirals in treatment protocolResearch article Published on 2021-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료법, 치료제, [키워드] analogue analogues Antiviral antiviral activity antiviral role carried characterized complex complexes COVID-19 COVID-19 drugs COVID-19 pandemic DFT drug drugs effective Efficiency ESR form in-silico Interaction ions Ligand metal ions molecular docking Neutral outcome pandemic pharmacophore profile Proteins suggested Support synthesis therapeutic Thiazol complexes Treatment Treatment protocol while [DOI] 10.1016/j.molstruc.2021.130961 [Article Type] Research article
Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16 †Chemistry Published on 2021-10-062022-10-29 Journal: RSC Chemical Biology [Category] COVID-19, [키워드] activities affinity analogue applied binding complex conserved Coronavirus infections develop drug drug design enzyme exhibiting experiment Health identification identify increasingly inhibit Interaction Intervention less Ligand methyltransferase nsp14 Proofreading Protein Replication reveal RNA SARS-CoV-2 Small molecules starting point Vaccine viral replication were used X-ray crystallography [DOI] 10.1039/d1cb00135c PMC 바로가기 [Article Type] Chemistry
Investigating a Newly Developed Educational Orthopedic Application for Medical Interns in a Before-after Quasi-clinical Trial StudyResearch Published on 2021-09-292022-10-28 Journal: BMC Medical Education [Category] Coronavirus, SARS, [키워드] analogue Analysis application benefit control group Controlled trial correlation Course COVID 19 defined Developed e-learning education method educational application Evidence Final FIVE greater group IMPROVE intern investigated knowledge Level Mashhad Medical application medical education Medical Science medication not significant notable orthopedic orthopedic application p value positive Practitioner provided question questionnaire randomization recruited Registered Result Satisfaction scale smartphone medical learning student subject supplementary material Total transfer Trial university Visual was done [DOI] 10.1186/s12909-021-02918-y PMC 바로가기 [Article Type] Research