Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research미래 대유행을 겨냥한 드노보 퓨린 합성 및 기초 연구 사례Immunology Published on 2021-06-112022-09-11 Journal: Frontiers in Immunology [Category] SARS, 신약개발, 치료제, [키워드] anti-viral drug Anti-viral therapy basic Basic science broad spectrum cellular de novo Evidence Future Host immunology & infectious diseases metabolic processes metabolism mitigate nucleotide synthesis Outbreaks pandemic pathway purine pursuit risk SARS-CoV-2 synthesis targeting theory therapeutic development Viral viral response viruses [DOI] 10.3389/fimmu.2021.694300 PMC 바로가기 [Article Type] Immunology
Antibody Responses and the Effects of Clinical Drugs in COVID-19 PatientsCOVID-19 환자에서 항체 반응과 임상 약물의 효과Immunology Published on 2021-06-092022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] Affiliated Hospital Anti-RBD IgG anti-viral drug Anti-viral drugs antibody Antibody titer Arbidol Bilirubin Chloroquine clinical Clinical treatment collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CRP demonstrated diagnosed direct bilirubin disease drug Effect ELISA Epidemic epidemic disease glucocorticoid Host humoral Humoral response humoral responses hydroxybutyrate dehydrogenase IgG and IgM IgM antibodies Infection Inflammatory responses laboratory-confirmed Laboratory-confirmed COVID-19 Lactate lactate dehydrogenase LDH Lopinavir Lopinavir/ritonavir lymphocyte Patient peripheral lymphocyte plasma plasma sample plasma samples Protein Protein subunit RBD Receptor binding domain reduced response Ritonavir SARS-CoV-2 SARS-CoV-2 nucleic acid serum severe symptom severe symptoms significantly Specific specific antibodies specific antibody Spike protein subunit suggested Sun Yat-sen therapy total bilirubin university while α-Hydroxybutyrate dehydrogenase [DOI] 10.3389/fimmu.2021.580989 PMC 바로가기 [Article Type] Immunology
Simple rapid in vitro screening method for SARS-CoV-2 anti-virals that identifies potential cytomorbidity-associated false positivesShort Report Published on 2021-06-092022-10-28 Journal: Virology Journal [Category] COVID-19, SARS, [키워드] activities Anti-viral anti-viral activity anti-viral drug antiviral drug arise assays candidate Cell Cell density cells cellular Concentration controls COVID-19 CPE Cytomorbidity Cytopathic effect cytotoxicity drug drug concentration Drug screening False positive False positives growth Hydroxychloroquine identify impairment in vitro include induce inhibit inhibit SARS-CoV-2 inhibited initial International methodology non-specific reduced Remdesivir replicate Replication Result ribavirin SARS-CoV-2 SARS-CoV-2 pandemic screening method simple staining Stress supplementary material Treatment Vero E6 cell viability virus [DOI] 10.1186/s12985-021-01587-z PMC 바로가기 [Article Type] Short Report
The three-component helicase/primase complex of herpes simplex virus-1article Published on 2021-06-092024-09-02 Journal: Open Biology [Category] 대상포진, [키워드] anti-viral drug Helicase herpesvirus DNA replication primase [DOI] 10.1098/rsob.210011 PMC 바로가기 [Article Type] article
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspectiveSARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp) 표적화: 인 실리코 관점Article Published on 2021-06-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] Affect anti-viral drug Anti-viral drugs approved drug binding binding affinity build cefuroxime clinically Compound COVID-19 derivative docking drug drug candidates Drug repurposing Effectiveness Efficacy Favipiravir Galidesivir Health Health crisis help Hydroxychloroquine IDX-184 in silico include inhibit SARS-CoV-2 inhibitor molecular molecular docking molecular dynamics Molecular dynamics simulation must New nucleotide Perspective Proteins punch RdRP reduce Remdesivir ribavirin RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 RdRp SARS-CoV-2 RNA Setrobuvir sofosbuvir tenofovir the SARS-CoV-2 Treatment viral infection viral infections Viral protein [DOI] 10.1080/07391102.2020.1761882 PMC 바로가기 [Article Type] Article
An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study분자 도킹 연구를 이용한 SARS-CoV-2 주요 단백질 분해 효소의 잠재적 억제제 식별에 대한 조사Article Published on 2021-06-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] Coronavirus, SARS, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting anti-fungals anti-viral drug anti-virals approach blind catalytic caused clinical trial clinical trials coronavirus Cys145 drug Efficiency Emetine followed by GLN189 Glu166 Gly143 Health Organization hesperidin highest HIS163 HIS164 His41 identify in vitro in vivo include Indinavir Infectious disease inhibitor inhibitors inhibitors of SARS-CoV-2 Lopinavir molecular molecular docking molecules MPro natural products nematodes new strain pandemic protease residue residues Ritonavir rutin SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 Mpro SARS-CoV-2 protease severe acute respiratory syndrome Coronavirus the SARS-CoV-2 Treatment viral replication virus WHO World Health Organization [DOI] 10.1080/07391102.2020.1763201 PMC 바로가기 [Article Type] Article
Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as targetSARS-CoV-2 주요 프로테아제를 표적으로 이용하는 인도 향신료에서 새로운 항 nCoV 약물 화합물 식별Article Published on 2021-06-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] active site ADME Amino acid amino acid residue amino acid residues analyzed Anti-viral anti-viral drug applied approach AutoDock binding affinity bioinformatics can be used Carnosol caused chemical compounds clinical trials Compound Corona virus corona virus disease-2019 (COVID-19) coronavirus coronavirus disease Coronavirus disease-19 COVID-19 database drug design Drug discovery drug target effort exhibited Health Health crisis highest binding affinity human population hydrogen hydrogen-bonding interaction identification inhibitor inhibitors of SARS-CoV-2 Interaction MD simulation MD simulations molecular molecular docking MPro nCoV novel Novel coronavirus Novel coronavirus (nCoV) novel coronavirus main protease (SARS-CoV-2 Mpro). pandemic protease Protein PubChem database raccoon SARS-CoV-2 main protease SARS-CoV-2 Mpro screened the disease these compounds unavailability Vaccine Virtual screening virus Zinc ZINC database [DOI] 10.1080/07391102.2020.1763202 PMC 바로가기 [Article Type] Article
The Anti-Viral and Anti-Inflammatory Properties of Edible Bird’s Nest in Influenza and Coronavirus Infections: From Pre-Clinical to Potential Clinical ApplicationPharmacology Published on 2021-05-072022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Actin Activation addressed allergenic anti-infammatory Anti-inflammatory anti-inflammatory agent anti-inflammatory effect Anti-viral anti-viral drug anti-viral effect antibody secretion Apoptosis appear application applied attenuate autophagy B-cell bird nest cellular Chinese traditional medicine clinical contaminant coronavirus COVID-19 cytokine cytokine secretion Defense Degradation derivative disease droplets drug edible bird’s nest Efficacy endosomal trafficking ENhance exacerbated Health highlighting host cells immunomodulatory effects IMPROVE in vitro in vivo models infected cells infections Influenza influenza A influenza infection lysosomal Nest Novel coronavirus oxidative pandemic Pathogenesis Pathogens Patient patients Potential pro-inflammatory cytokines proliferation property protective effect reduce replicated reported respiratory viral infections secretion severe symptom sialic acid suppresse therapeutic therapeutic effects transmitted treat Vaccine viral replication virus [DOI] 10.3389/fphar.2021.633292 PMC 바로가기 [Article Type] Pharmacology
A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors Research Published on 2021-04-272022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 치료제, [키워드] anti-SARS-CoV-2 anti-viral drug caused COVID-19 drug design drugs EC50 value effective feasibility Host impair inhibit SARS-CoV-2 inhibitor inhibitors nucleocapsid protein public health Replication RNA-dependent RNA polymerases SARS-CoV-2 translation Treatment Viral RNA virus [DOI] 10.1038/s41401-021-00668-7 [Article Type] Research
A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials임상의가 COVID-19 시험을 위한 항바이러스제를 선택하는 데 도움이 되는 컴퓨터 접근 방식Article Published on 2021-04-272022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 신약개발, 임상, 치료제, [키워드] analysed anti-viral drug Antiviral antiviral treatments antivirals applied approach assist association best build Chemical structure Clinical research clinical trial clinical trials clinician Combination Computational biology and bioinformatics Computational drug computational method Computational methods Computational models coronavirus COVID-19 curated cure database death drug drug target Efficacy experimental protocol experimental protocols genomic help IMPROVE information interactions machine learning model machine learning models mutate mutated Older open positioning predict problems Prophylactic Remdesivir renal Research similarity sofosbuvir Stage Strains Symptoms sync tenofovir Tenofovir alafenamide tenofovir disoproxil the vaccine TRAIL Treatment treatment of COVID-19 Trial umifenovir vaccine efficacy Vaccines virus viruses [DOI] 10.1038/s41598-021-88153-3 PMC 바로가기 [Article Type] Article