Effectiveness of neutralizing antibody cocktail in hemodialysis patients: a case series of 20 patients treated with or without REGN-COV2혈액투석 환자에서 중화항체 칵테일의 효과: REGN-COV2 유무에 관계없이 20명의 환자를 대상으로 한 일련의 사례Original Article Published on 2022-02-182022-09-12 Journal: Clinical and experimental nephrology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Admission Adverse reaction antibodies antibody cocktail approval average can be used case sery COVID-19 death dialysis disease duration of hospitalization effective end-stage kidney disease Fever FIVE global pandemic Hemodialysis high risk hospital Infection intravenous Japan Kidney disease less medication Mild moderate disease neutralizing antibody Patient patients patients treated patients with COVID-19 patients with SARS-CoV-2 Pneumonia progressed REG-COV2 (a neutralizing antibody cocktail) REGN-CoV2 Safe severe disease severity shown treated Treatment [DOI] 10.1007/s10157-021-02151-3 PMC 바로가기 [Article Type] Original Article
Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variantsCoronaviruses Published on 2022-02-102022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] ACE2-binding site Analysis antibodies antibody cocktail Antiviral benefit Beta binding change Combination convalescent patient COVID-19 COVID-19 pandemic decrease Delta effective Efficacy Efficiency epitope etesevimab Gamma hACE2 JS026 lung mAb Neutralizing Neutralizing antibodies neutralizing antibody overlap pathological changes recognize reduced SARS-CoV-2 SARS-CoV-2-RBD shown significantly the spike protein therapeutic transgenic mice Treatment variant variants variants of concern virus titer wild-type SARS-CoV-2 [DOI] 10.1080/22221751.2022.2032374 PMC 바로가기 [Article Type] Coronaviruses
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성Research Paper Published on 2022-01-012022-09-01 Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type [DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper
ZRC3308 Monoclonal Antibody Cocktail Shows Protective Efficacy in Syrian Hamsters against SARS-CoV-2 InfectionZRC3308 모노클로 날 항체 칵테일은 SARS-COV-2 감염에 대한 시리아 햄스터에서 보호 효능을 보여줍니다.Article Published on 2021-12-032022-09-01 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] 1:1 antibody cocktail appear AY.1 B.1 B.1.1.7 B.1.351 B.1.617.2 binding affinities binding affinity circulation cocktail COVID-19 COVID-19 case COVID-19 treatment demonstrated effective epitope Epitopes hamster hamsters immune effector function in vitro mAb mAbs monoclonal antibody Neutralizing progressed Prophylactic Prophylaxis RBD of SARS-CoV-2 reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variant severe disease show Spike protein therapeutic activity therapy Treatment ZRC3308 [DOI] 10.3390/v13122424 PMC 바로가기 [Article Type] Article
REGEN-COV ® antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantificationREGEN-COV ® 항체 칵테일 생물분석 전략: 약물 정량을 위한 LC-MRM-MS 및 면역분석 방법의 비교Comparative Study Published on 2021-12-012022-09-12 Journal: Bioanalysis [Category] MERS, SARS, 진단, [키워드] addition Analysis anti-SARS-CoV-2 antibody cocktail bioanalytical Bland-Altman Concentration correlation COVID-19 COVID-19 pandemic Critical dose drug drug concentration assay ECL immunoassay Initially linear monoclonal antibody monoclonal antibody therapeutic. parameters pharmacokinetic data produced profile public health emergency quantification REGEN-COV Regeneron Result SARS-CoV-2 supported targeted therapy therapeutic therapy USA was performed was used [DOI] 10.4155/bio-2021-0190 PMC 바로가기 [Article Type] Comparative Study
Simple workflow to repurpose SARS-CoV-2 swab/serum samples for the isolation of cost-effective antibody/antigens for proteotyping applications and diagnosisSARS-CoV-2 면봉/혈청 샘플의 용도를 변경하여 단백질형 분석 응용 프로그램 및 진단을 위한 비용 효율적인 항체/항원 분리를 위한 간단한 워크플로Article Published on 2021-12-012022-09-12 Journal: Analytical and bioanalytical chemistry [Category] MERS, SARS, 진단, [키워드] affecting analyses antibody antibody cocktail Antigen Antigen/antibody purification antigens approach can be used COVID-19 pandemic Diagnosis diagnostic ELISA Initially Isolation isothermal titration calorimetry Lateral lateral flow lateral flow assay Magnetic nanoparticle (MNP)–based separation mass mass spectrometry MNP pandemic peptide point-of-care tests purified Research SARS-CoV-2 SDS-PAGE serum significantly simple specific antibody supply therapeutic was performed [DOI] 10.1007/s00216-021-03654-4 PMC 바로가기 [Article Type] Article
Antibody cocktail effective against variants of SARS-CoV-2SARS-CoV-2 변종에 효과적인 항체 칵테일Research Published on 2021-11-232022-09-10 Journal: Journal of Biomedical Science [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta) acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha analyzed antibody antibody cocktail B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 Beta binding ability binding activity Brazil caused circulating SARS-CoV-2 variant cocktail Cocktail therapy Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta effective Efficacy Epsilon evaluate exhibited Gamma hamsters high mutation rate India Iota mutation rate neutralization Neutralizing neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody new SARS-CoV-2 New York Plaque assay plaque assays Post-infection PRNT Prophylactic pseudovirus pseudoviruses Receptor-binding domain (RBD) respiratory Result retained RNA virus SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) South Africa Spike protein Spike proteins tested the SARS-CoV-2 the spike protein therapeutic effect Treatment United Kingdom Vaccine variant variants variants of SARS-CoV-2 [DOI] 10.1186/s12929-021-00777-9 PMC 바로가기 [Article Type] Research
Antiviral monoclonal antibody cocktails as a modern weapon in combating pandemics전염병과 싸우는 현대 무기로서 항 바이러스 단일 클론 항체 칵테일Editorial Published on 2021-11-022022-09-01 Journal: Therapeutic Delivery [Category] COVID19(2023년), Fulltext, SARS, 진단, 치료제, [키워드] antibody cocktail Antiviral coformulation combating Formulation high concentration monoclonal antibody pandemic Pandemics REGEN-COV SARS-CoV-2 [DOI] 10.4155/tde-2021-0079 PMC 바로가기 [Article Type] Editorial
Compassionate use of REGN-COV2 in the treatment of COVID-19 in a patient with impaired humoral immunityCase report Published on 2021-11-012022-10-05 Journal: Clinical Infection in Practice [Category] 변종, 치료법, [키워드] acute respiratory syndrome administration agammaglobulinemia antibody antibody cocktail Clinical course cohort of patient compassionate use Consent consequence convalescent plasma coronavirus coronavirus disease COVID-19 described develop Dexamethasone disease heterogeneous highlight hospital Host Humoral immunity immune response Immunosuppression information modulating Mutation Nasopharyngeal swab negativity Patient patients Pneumonia REGN-CoV2 remained Remdesivir SARS-CoV-2 SARS-CoV2 Swab symptomatic the patient Treatment was obtained with COVID-19 X-linked XLA [DOI] 10.1016/j.clinpr.2021.100089 [Article Type] Case report
Structure-guided antibody cocktail for prevention and treatment of COVID-19코로나19 예방 및 치료를 위한 구조유도항체 칵테일Research Article Published on 2021-10-212022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단, [키워드] accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antivirals approach characterization chimeric chimeric antibodies Combination complex contagious coronavirus COVID-19 COVID-19 pandemic cryo demonstrated develop development disease Disease progression drug resistance drugs effective Efficacy Epitopes escape mutant escape mutants group host immunity in vitro in vivo Microscopy mitigate mutants neutralization activity neutralization test neutralize Neutralizing antibodies neutralizing antibody non-overlapping epitope non-overlapping epitopes Patient plaque reduction neutralization Plaque reduction neutralization test Post-infection Prevent prevent disease progression PRNT Prophylactic pseudovirus RBD Receptor-binding domain receptor-binding motif reduce respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus Spike protein suggested target the RBD the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic drug therapeutic effect therapy treat Treatment utility variants of SARS-CoV-2 Viral Viral load [DOI] 10.1371/journal.ppat.1009704 PMC 바로가기 [Article Type] Research Article