The Anti-inflammatory Effect of the Tricyclic Antidepressant Clomipramine and Its High Penetration in the Brain Might Be Useful to Prevent the Psychiatric Consequences of SARS-CoV-2 InfectionPharmacology Published on 2021-03-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” animal models anti-inflammatory action anti-inflammatory property antidepressant antidepressants Blood brain barrier Brain caused clomipramine complications consequence Consequences coronavirus disease COVID-19 death Dexamethasone disease Effect effective explain help imperative in vitro in vivo indicated Inflammation management Mental neurological manifestations penetrate Prevent psychiatric diseases Psychiatric disorders psychiatric pathology reduce repositioning respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection shown Tocilizumab Tricyclic viral encephalitis viral infection worsening [DOI] 10.3389/fphar.2021.615695 PMC 바로가기 [Article Type] Pharmacology
Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptorCOVID-19 감염 치료를 위한 CNS 약물의 용도 변경: 시그마-1 수용체 표적화Review Published on 2021-03-012022-08-31 Journal: European archives of psychiatry and clinical neuro [Category] 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adult outpatient adult outpatients antidepressant approved arketamine article candidate caused cells Central nervous system Clinical deterioration clinical trial CNS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutamesine demonstrated donepezil drug Endoplasmic reticulum fluvoxamine global pandemic high affinity ifenprodil indicate infected individuals infected with SARS-CoV-2 knockdown knockout market Novel coronavirus novel coronavirus disease Prevent Prophylactic protein-protein interaction receptor reductions in Replication repurposing respiratory robust SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected individual SARS-CoV-2-infected individuals SARS-CoV-2-infected patients severe acute respiratory syndrome Coronavirus sigma sigma-1 receptor SIGMAR1 status therapeutic drug therapeutic target treat Treatment Viral viral spread [DOI] 10.1007/s00406-020-01231-x PMC 바로가기 [Article Type] Review
Monitoring the impact of COVID-19 pandemic on mental health: a public health challenge? Reflection on Italian dataCOVID-19 전염병이 정신 건강에 미치는 영향 모니터링: 공중 보건 문제? 이탈리아 데이터에 대한 반성Article Published on 2021-01-012022-09-11 Journal: Social psychiatry and psychiatric epidemiology [Category] SARS, 치료기술, [키워드] activated addition Admission Analysis antidepressant anxiety symptom Care COVID-19 epidemic COVID-19 pandemic depressive Effect followed by General population Google greater help Hospitalization increase in individual Intervention Italian Italian population Italy lockdown lombardy Medicine Medicines Mental mental health Ministry of Health monitoring outlined pandemic Prevalence protection Psychiatric psychological support Psychological well-being public health reduction in Reflection reported request request for Research significant increase telephone number [DOI] 10.1007/s00127-020-01971-0 PMC 바로가기 [Article Type] Article
Clinical stage molecule PT150 is a modulator of glucocorticoid and androgen receptors with antiviral activity against SARS-CoV-2임상 단계 분자 PT150은 SARS-CoV-2에 대한 항바이러스 활성이 있는 글루코코르티코이드 및 안드로겐 수용체의 조절제입니다.Article Published on 2020-12-012022-09-11 Journal: Cell cycle (Georgetown, Tex.) [Category] SARS, 치료제, [키워드] ACE2 activity androgen Androgen receptor Anti-SARS-CoV-2 Activity antidepressant Antiviral antiviral activities antiviral activity Cell cellular clinical clinical trial Concentration cortisol COVID-19 COVID-19 progression downregulation effective epithelial lining glucocorticoid Glucocorticoid antagonist Glucocorticoid receptor glucocorticoid receptor (GR immunomodulatory effect IND inhibitory member modulating modulation molecules Phase 1 Phase 2 phase 2 clinical trials platform predominant PT150 receptor safety profile SARS-CoV-2 suggested tested therapeutic TMPRSS2 TMPRSS2 expression variety virus [DOI] 10.1080/15384101.2020.1859752 PMC 바로가기 [Article Type] Article
An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general populationResearch Article Published on 2013-02-262024-09-02 Journal: BMC Family Practice [Category] 대상포진, [키워드] antidepressant Antiepileptic incidence neuropathic pain Painful diabetic neuropathy Phantom limb pain Post-herpetic neuralgia primary care Treatment [DOI] 10.1186/1471-2296-14-28 PMC 바로가기 [Article Type] Research Article