Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort경증 회복기 코호트에서 SARS-CoV-2 유도 체액 및 세포 면역 반응과 관련하여 급성 감염 중 COVID-19 관련 증상의 유병률Article Published on 2022-07-012022-09-12 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute infection antibody antiviral immunity association Cellular immune response cellular immune responses Cohort convalescent convalescent individual correlation cough COVID-19 COVID-19 symptom COVID-19 symptoms disease severity effective eight evaluated humoral humoral immune response humoral immune responses IgG immune immune response intensities intensity Loss of Smell majority no difference polymerase chain positive Prevalence Prevent questionnaire recent reduced SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2-specific T cell Serum level severe symptom severity shown Symptom symptom severity Symptoms T cell response T cells virus clearance were assessed [DOI] 10.1016/j.ijid.2022.04.019 PMC 바로가기 [Article Type] Article
When RING finger family proteins meet SARS-CoV-2Review Published on 2022-07-012023-07-08 Journal: Journal of medical virology [Category] COVID19(2023년), [키워드] antiviral immunity RNF family proteins SARS-CoV-2 Viral immune evasion [DOI] 10.1002/jmv.27701 [Article Type] Review
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review
Beyond GWAS-Could Genetic Differentiation within the Allograft Rejection Pathway Shape Natural Immunity to COVID-19?GWAS를 넘어 동종이식 거부 경로 내 유전적 분화가 COVID-19에 대한 자연 면역을 형성할 수 있습니까?Article Published on 2022-06-032022-09-11 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] Allograft allograft rejection Analysis annotation antiviral immunity applied Biomarker Biomarkers chromosome chromosome 6 chromosomes clinical presentation component components COVID-19 COVID-19 infection COVID-19 infections cumulative demonstrated differentiation disease Factor Genetic genetic variants genetics Genome-wide association study genomic GWAS Health help hospitalisation Host identify immune response immune responses immune system immunisation Infection investigated KEGG KEGG pathways Linear model majority mapped metabolic pathway metabolic pathways natural nucleotide outcome pathway Pathways Patient rejection resistance risk Risk assessment self Sequencing severe COVID-19 Severe COVID-19 Infection shape single nucleotide Single nucleotide polymorphism single variant SNP SNPs susceptibility Treatment variant whole genome Whole genome sequencing [DOI] 10.3390/ijms23116272 PMC 바로가기 [Article Type] Article
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19인터페론 경로 루푸스 위험 대립 유전자는 급성 COVID-19로 인한 사망 위험을 조절합니다Article Published on 2022-06-012022-09-11 Journal: Translational research : the journal of laboratory [Category] 바이오마커, 변종, 유전자 메커니즘, 치료제, [키워드] Activation activator acute COVID-19 age allele alleles analyzed antiviral immunity Biomarker Blood BMI = body mass index body mass body mass index C-reactive protein cGMP contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 = coronavirus disease 2019 Critical CRP = C-reactive protein D-dimer death Defense disease domain Effect gain-of-function Genetic genetic information genetic risk factor Genotype groups Haplotype Helicase high risk idea IFIH1 IFIH1 = interferon-induced with helicase c domain 1 IFN IFN = interferon IFN pathway Increased interferon interferon regulatory factor IRF = interferon regulatory factor IRF5 IRF7 IRF8 lupus erythematosus modulate Mortality nucleotide NYU = New York University older subjects OR = odds ratio pathway Patient positive Predictive Primary outcome PRKG1 PRKG1 = protein kinase cGMP-dependent 1 protective effect Protective effects Protein protein kinase Regulatory risk risk allele risk factor risk of death significantly Single nucleotide polymorphism SLE SLE = systemic lupus erythematosus SNP = single nucleotide polymorphism STAT4 STAT4 = signal transducer and activator of transcription 4. subjects Support systemic lupus erythematosus Transcription troponin Type Type I IFN type I interferon variants viral infections York younger patient younger patients [DOI] 10.1016/j.trsl.2022.01.007 PMC 바로가기 [Article Type] Article
High Expression of HERV-K (HML-2) Might Stimulate Interferon in COVID-19 PatientsHERV-K(HML-2)의 높은 발현은 COVID-19 환자에서 인터페론을 자극할 수 있습니다Article Published on 2022-05-072022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate activated Affect antiviral immunity blood sample Blood samples Cell cGAS chromosome collected COVID-19 COVID-19 patient COVID-19 patients distribution expressed expression Gene ontology Genes GO analysis healthy healthy controls HERV HERV-K HERV-K (HML-2) HML-2 Host human body IFIT1 IFN-I IFNB1 infected with SARS-CoV-2 Interaction interferon ISG15 mapped marker Next-generation sequencing pathway Patient qPCR regulate SARS-CoV-2 secretion STING Vero Vero cells was performed [DOI] 10.3390/v14050996 PMC 바로가기 [Article Type] Article
Interferon blockade in lupus: effects on antiviral immunity News & Views Published on 2022-05-062022-10-05 Journal: Nature reviews. Nephrology [Category] 치료제, [키워드] antiviral immunity blockade Effect [DOI] 10.1038/s41581-022-00581-0 [Article Type] News & Views
Effective Anti-SARS-CoV-2 Immune Response in Patients With Clonal Mast Cell Disorders클론 비만 세포 장애 환자에서 효과적인 항 SARS-CoV-2 면역 반응Article Published on 2022-05-012022-09-11 Journal: The journal of allergy and clinical immunology. In [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] absence Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adaptive immune response anti-SARS-CoV-2 antiviral immune response antiviral immunity B cells Cell cell activation characterized circulating clinical follow-up Clonal mast cell activation syndrome collected coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical disorder ELISA evaluated French hospital Humoral response humoral responses IFN-γ IgA IgG IgGs immune response Innate immunity marker mast cell Mast cell activation disorders Mast cells Mastocytosis mechanical ventilation MOST Neutralizing Neutralizing antibodies noninvasive outcome oxygen Patient patients PCR rare disease required respiratory response risk SARS-CoV-2 Serologically severe coronavirus disease steroid steroid therapy Stimulation syndrome T cell T cells T-cell therapy tryptase Two patient two patients was measured [DOI] 10.1016/j.jaip.2021.12.038 PMC 바로가기 [Article Type] Article
Immunonutrition and SARS-CoV-2 Infection in Children with ObesityReview Published on 2022-04-202023-07-02 Journal: Nutrients [Category] COVID19(2023년), SARS, [키워드] antiviral immunity Dysbiosis gut–lung axis Immunonutrition micronutrients obesity SARS-COV-2 infection [DOI] 10.3390/nu14091701 PMC 바로가기 [Article Type] Review
Abnormal global alternative RNA splicing in COVID-19 patientsCOVID-19 환자의 비정상적인 글로벌 대체 RNA 스플라이싱Article Published on 2022-04-142022-09-11 Journal: PLoS Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affecting Alter Analysis antiviral immunity Blood coagulation CD74 changes in Clinical severity contribute correlated COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients cytokine production disrupt domain down-regulated dysregulation ExoN expression functional highlight Host host transcriptome induce Infection Intensive LRRFIP1 neutrophil neutrophil activation proteomic reduced RNA splicing SARS-CoV-2 SARS-COV-2 infection sequencing data severe COVID-19 patient severe COVID-19 patients systematic analysis therapeutic activity therapy transcript Transcriptome transcriptome analysis transcriptomic transcripts viral infections widespread [DOI] 10.1371/journal.pgen.1010137 PMC 바로가기 [Article Type] Article