A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation고염증을 동반한 COVID-19 폐렴의 치료를 위한 Clazakizumab의 무작위 이중 맹검 위약 대조 시험Clinical Trial Published on 2022-09-012022-09-12 Journal: Critical Care Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 1:1 accompanied added Bayesian benefit board changes Clazakizumab Clinical outcome clinical status Controlled COVID-19 COVID-19 disease Critical cumulative double-blinded dropped enrolled Frequency greater High-dose hospitalized patient hyperinflammation ICU ICU admission inhibitor Inpatient interleukin-6 intubation Logistic low-dose measurement monitoring Odds ratio outcome Patient patients patients hospitalized Placebo placebo-controlled Poisson regression model Primary outcome Randomized receiving recommendations risk Safety seamless secondary secondary outcome severe COVID-19 disease significantly suggested survival Trial Ventilation ventilator-free survival were used with COVID-19 [DOI] 10.1097/CCM.0000000000005591 PMC 바로가기 [Article Type] Clinical Trial
Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis Research Published on 2022-08-302022-10-05 Journal: Nature Communications [Category] 변종, [키워드] acquisition Analysis antibiotic average Bayesian changes in clade compensatory mutation complex distributions drug drugs Epidemic Eurasia Evolution Factor Genetic Genome sequencing isolate Lineage locus MDR MDR-TB Mortality Mutation Mycobacterium tuberculosis Prevalence regimens responsible Spread strain Strains Tolerance Transmission Tuberculosis widespread [DOI] 10.1038/s41467-022-32455-1 [Article Type] Research
Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from ChinaArticle Published on 2022-08-292022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] adaptive addition America Analysis analyzed Asia Bayesian Bayesian inference caused Characteristics China coronavirus COVID-19 epidemic Cross-species transmission distribution Dynamics event Evolution evolutionary dynamics finding genetic diversity Genome sequence data genotypes highlighting Human humans infect likelihood lineages maximum measure membrane fusion Migration Pandemics PDCoV phylogeography Porcine deltacoronavirus Positive selection recent Sample spatiotemporal Spike protein Surveillance Suspected TGEV transmissible gastroenteritis virus Transmission transmission rate transmitted [DOI] 10.3390/ijms23179786 PMC 바로가기
Trends in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seroprevalence in Massachusetts Estimated from Newborn Screening Specimens신생아 선별 검체에서 추정한 매사추세츠 주의 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 혈청 유병률의 추세Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody Bayesian black collected Community Concordance coronavirus coronavirus 2 cumulative cumulative incidence diagnostic estimate Estimated fraction higher odd highest identify incidence increase in Massachusett Massachusetts Maternal maternal antibody Newborn newborn screening Protective public health reported representing respiratory retrospective risk SARS-CoV-2 SARS-CoV-2 transmission Screening Seroprevalence specificity specimen Surveillance susceptible sustained Transmission trend widespread [DOI] 10.1093/cid/ciac158 PMC 바로가기 [Article Type] Article
Using patient biomarker time series to determine mortality risk in hospitalised COVID-19 patients: A comparative analysis across two New York hospitals입원한 COVID-19 환자의 사망 위험을 결정하기 위해 환자 바이오마커 시계열을 사용: 두 뉴욕 병원에 대한 비교 분석Article Published on 2022-08-182022-09-11 Journal: PLoS ONE [Category] SARS, 바이오마커, 치료기술, [키워드] Accuracy Admission Analysis Bayesian Biomarker Biomarkers center changes in clinical measurement cohorts COVID-19 COVID-19 patient death determine died difficulty discharge discharged explain Factor focus generalisability Health Sciences high risk high risk patients highlight hospital hospitalisation hospitalised hospitals Maimonide Maimonides Markov median Model Mortality mortality risk New New York outcome Patient patient cohort patient cohorts patient mortality patients Predictive prognostic model Prognostic models question raising restrict risk risk of COVID-19 Science sensitivity single hospital state tested university utility variables [DOI] 10.1371/journal.pone.0272442 PMC 바로가기 [Article Type] Article
Effect of interleukin-6 receptor antagonists in critically ill adult patients with COVID-19 pneumonia: two randomised controlled trials of the CORIMUNO-19 Collaborative GroupCOVID-19 폐렴이 있는 위독한 성인 환자에서 인터루킨-6 수용체 길항제의 효과: CORIMUNO-19 공동 그룹의 2건의 무작위 대조 시험Article Published on 2022-08-102022-09-11 Journal: The European Respiratory Journal [Category] Fulltext, SARS, 임상, [키워드] 95% CI antagonist anti-IL-6 receptor assigned Bayesian clinical trials clinically controlled clinical trials coronavirus disease Coronavirus disease 2019 COVID-19 credible interval CrI Critically ill Critically ill patient critically ill patients determine Effect events group hazard ratio IMPROVE indicated interleukin-6 receptor intravenously investigator-initiated mechanical ventilation median multicentre NIV Noninvasive ventilation not need numbers of patient Open-label outcome Patient patients with COVID-19 Pneumonia posterior probability randomised randomised controlled randomised controlled trial Randomly receive receptor risk of death SARI sarilumab significantly TCZ TOCI Tocilizumab Trial usual care with COVID-19 [DOI] 10.1183/13993003.02523-2021 PMC 바로가기 [Article Type] Article
Statistical framework to support the epidemiological interpretation of SARS-CoV-2 concentration in municipal wastewater도시 폐수 내 SARS-CoV-2 농도의 역학 해석을 지원하는 통계적 프레임워크Article Published on 2022-08-052022-09-11 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bayesian Canada Concentration coronavirus COVID-19 pandemic Data analysis data set detect detectable epidemiological functional infected individual infected individuals Interpretation observation observations Previous studies Ribonucleic acid RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity statistical statistical framework Support Surveillance surveillance data trajectory Viral concentration viral concentrations virus wastewater [DOI] 10.1038/s41598-022-17543-y PMC 바로가기 [Article Type] Article
The comparative effectiveness of COVID-19 monoclonal antibodies: A learning health system randomized clinical trialRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Contemporary clinical trials [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] 95% CI adjusted odds ratio age Analysis antibody authorization Bayesian COVID-19 criteria death decrease defined Effectiveness Emergency enrolled equivalence funding Government Health health system Hospitalization inferiority IQR Local mAb median Mild moderate Moderate COVID-19 monoclonal neutralize Odds ratio outcome Patient Placebo Platform trial posterior probability Probability provided random randomized clinical trial Registered relative reported SARS-CoV-2 Sex statistical Treatment Trial [DOI] 10.1016/j.cct.2022.106822 PMC 바로가기 [Article Type] Randomized Controlled Trial
The effect of SARS-CoV-2 vaccination on post-acute sequelae of COVID-19 (PASC): A prospective cohort studySARS-CoV-2 백신 접종이 COVID-19의 급성 후유증(PASC)에 미치는 영향: 전향적 코호트 연구Article Published on 2022-07-302022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 1:1 age antibody association Bayesian comparable COVID-19 Critical enrolled Evidence Follow-up follow-up period full recovery groups Hierarchical illness onset immunological IMPROVE Linear regression Logistic regression Long Long COVID mechanism median Mild not differ number of symptom obesity participant Participants PASC Patient Post-acute sequelae proportion prospective cohort study RBD-binding IgG reported SARS-CoV-2 SARS-CoV-2 vaccination Sex spike Symptom the mean therapeutic effect therapeutic vaccine trajectory vaccination [DOI] 10.1016/j.vaccine.2022.05.090 PMC 바로가기 [Article Type] Article
Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study노인 급성 치료 병원에서 여러 번 발생하는 SARS-CoV-2의 전염 사슬 재구성: 역학 및 게놈 결합 후향적 연구Article Published on 2022-07-192022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 attack rate attack rates Bayesian Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 credible interval CrI determine Elderly patient elderly patients epidemiological evaluated event expected foundation Genetic genomic geriatric hospitals greater HCW HCWs healthcare worker Healthcare workers Healthcare-associated infection highlight hospital improvement Improvements Infection infection control Infection prevention Infectious disease involved late phase limit Medicine Microbiology MOST Non-COVID-19 patients nosocomial nosocomial COVID-19 nosocomial outbreak Nosocomial outbreaks Nosocomial transmission occurred outbreak pandemic Patient patients performed positive posterior probability proportion random ranged reconstructed reconstruction retrospective retrospective cohort study room SARS-CoV-2 SARS-CoV-2 RT-PCR Science secondary cases sequencing data severe acute respiratory syndrome Coronavirus spring statistically significant study period supported Transmission Transmission dynamics transmission pattern viruses ward [DOI] 10.7554/eLife.76854 PMC 바로가기 [Article Type] Article