betacoronaviruses – Page 3 – Communicable Diseases Research

First detection of Hedgehog coronavirus 1 in Poland

Article

Published on 2022-02-112022-10-29
Journal: Scientific Reports [Category] Coronavirus,

Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide

SARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석

Immunology

Published on 2022-01-052022-09-11
Journal: Frontiers in Immunology [Category] 변종, 진단,

Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replication

423

Published on 2021-11-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19,

[키워드] acute respiratory syndrome affecting Analysis approach Betacoronavirus betacoronaviruses biochemical C-terminal catalytic cellular characterized conserved coronavirus CoV CoVs Critical defined Degradation develop domain drugs enzymatic activity enzyme Exoribonuclease feature genomes highlight host cell cytoplasm identify in silico in viral inhibitor innate immune involved MERS-CoV Messenger RNA methyltransferase Middle East MOST mRNA mRNA capping mRNAs Mutation N-terminal nonstructural protein 14 nsp14 nsp14-ExoN pandemic phenotype PROTECT replicate Replication replicative residue reveal RNA synthesis SARS-CoV SARS-CoV-2 selected Significance site-directed mutagenesis Substitution subunit syndrome targets tested translation unique viability Virological virus was used yielding
[DOI] 10.1073/pnas.2108709118 PMC 바로가기 [Article Type] 423

Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

Cellular and Infection Microbiology

Published on 2021-11-182022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] ACE2 analyzed angiotensin-converting enzyme 2 Betacoronavirus betacoronaviruses bind binding bioinformatics Can canonical changes in collected Computational study conformational change conserved coronavirus 2 coronavirus strains domain ENhance entry receptor explain expression Factor help Host host cell identify independent independent of integrin integrin-binding motif Integrins ligands mapped motif motifs Mutation occur Other phylogenetically predicted RaTG13 recent recorded Region RGD rotaviruses SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein sequence sequence similarity shown solvent spike Spike protein Spike proteins spike receptor-binding domain suggested the SARS-CoV-2 the spike protein viral pathogens virus
[DOI] 10.3389/fcimb.2021.765300 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Methods to Measure Antibody Neutralization of Live Human Coronavirus OC43

Article

Published on 2021-10-142022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

A novel predictor of ACE2-binding ability among betacoronaviruses

Original Research Article

Published on 2021-10-132022-11-01
Journal: Evolution, Medicine, and Public Health [Category] COVID-19,

[키워드] ACE2 ACE2 binding ACE2 receptor acute respiratory syndrome Amino acid amino acids angiotensin-converting enzyme 2 applied approach Betacoronavirus betacoronavirus spike protein betacoronaviruses binding biosurveillance caused cell entry Cluster coronavirus Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 pandemic curtail death determine develop domains effort Evolution functional Host Human human ACE2 receptor human cell human cells humans infect less likelihood novel outbreak Outbreaks Phylogenetic phylogenetic analyses physicochemical physicochemical property Prevent Protein RBD receptor Receptor binding domain Result SARS-CoV SARS-CoV-2 sequence shown the spike protein Variation virus Virus evolution zoonotic Zoonotic coronavirus
[DOI] 10.1093/emph/eoab032 PMC 바로가기 [Article Type] Original Research Article

An Opportunistic Survey Reveals an Unexpected Coronavirus Diversity Hotspot in North America

기회 조사에 따르면 북미의 예상치 못한 코로나 바이러스 다양성 핫스팟이 나타납니다.

Article

Published on 2021-10-072022-09-10
Journal: Viruses [Category] MERS, SARS, 치료기술,

Genomic Characterization of Diverse Bat Coronavirus HKU10 in Hipposideros Bats

Article

Published on 2021-09-292022-10-28
Journal: Viruses [Category] Coronavirus,

[키워드] Accessory genes addition Alpha alphacoronavirus Aselliscus bat bat coronavirus bat coronavirus HKU10 bats betacoronaviruses Cell cell tropism characterization China circulating collected Continuous coronavirus Coronaviruses correlated defined demonstrated distribution Evolution expand fecal samples full-length genome Genes genetic diversity Genotype Guangxi Hainan Hipposidero interspecies transmission investigated lentivirus lineages much higher New novel lineage Phylogenetic analysis polyproteins positive reported reservoir reverse transcriptase PCR Rousettus screened selective sequenced spike gene strain variant variety virus zoonotic disease
[DOI] 10.3390/v13101962 PMC 바로가기 [Article Type] Article

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

마카크에서 보조제 SARS-CoV-2 수용체 결합 도메인 나노입자 백신의 효능 및 범위

420

Published on 2021-09-212022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition adjuvant animals antibody Antibody titers B.1.351 betacoronaviruses breadth CD4+ T cell Cellular immune response cellular response Cellular responses concerning coronavirus Coverage COVID-19 vaccine cross-neutralization activity displaying domain Efficacy eight elicit emergence evaluate ferritin Formulation High-dose highlighting humoral Humoral and cellular immune responses immune responses Immunity lower airway macaque macaques nanoparticle Neutralizing pandemic potency PROTECT Protein QS-21 Rapid receiving Receptor-binding domain reduce Replication respiratory respiratory tract response robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants Serum neutralizing antibody Seven severe acute respiratory syndrome Coronavirus Significance Spike protein Support T cell T cell responses Th1 the receptor-binding domain the Sarbecovirus the SARS-CoV-2 two-dose regimen undetectable upper and lower airways vaccination Vaccine Vaccine development variant Viral viral replication VoC VOCs WA1/2020
[DOI] 10.1073/pnas.2106433118 PMC 바로가기 [Article Type] 420

Broad betacoronavirus neutralization by a stem helix-specific human antibody

줄기 나선 특이적 인간 항체에 의한 광범위한 베타 코로나바이러스 중화

Article

Published on 2021-09-032022-09-11
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 비임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Betacoronavirus betacoronaviruses breadth breath convalescent individuals coronavirus COVID-19 cross-reactivity Fc-mediated effector functions FIVE framework functional hamster hamsters highlight Human mAb mAbs membrane fusion molecular basis monoclonal antibodies monoclonal antibody neutralization neutralization breadth neutralize Pseudotyped virus Pseudotyped viruses reduce SARS-CoV-2 severe acute respiratory syndrome Coronavirus somatic mutations specificity spike glycoprotein STEM These data Vaccine variant viral burden viral neutralization
[DOI] 10.1126/science.abj3321 PMC 바로가기 [Article Type] Article