“Don, doff, discard” to “don, doff, decontaminate”—FFR and mask integrity and inactivation of a SARS-CoV-2 surrogate and a norovirus following multiple vaporised hydrogen peroxide-, ultraviolet germicidal irradiation-, and dry heat decontaminations"돈, 벗고, 버리다"에서 "벗고, 벗고, 오염 제거" - 다중 기화된 과산화수소, 자외선 살균 조사 및 건열 오염 제거 후 SARS-CoV-2 대리 및 노로바이러스의 FFR 및 마스크 무결성 및 비활성화Research Article Published on 2021-05-192022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] accelerates Affect approach Bacterial both virus both viruses coronavirus decrease demonstration detectable dry heat Efficiency evaluate filtration FIVE hydrogen hydrogen peroxide inactivated inactivation information inoculated loss of infectivity magnitude Mask Masks Multiple murine pandemic Pathogens performed Personal protective equipment PPE provide remained Respirator respirators respiratory Respiratory Coronavirus Result room temperature SARS-CoV-2 SARS-CoV-2 pandemic Seven shown strain submitted supply surgical TCID temperature the SARS-CoV-2 titre ultraviolet Viral virus viruses were measured [DOI] 10.1371/journal.pone.0251872 PMC 바로가기 [Article Type] Research Article
Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium인간 호흡기 상피에서 SARS-CoV-2 및 SARS-CoV에 대한 서로 다른 온도 의존성 바이러스-숙주 역학Research Article Published on 2021-03-292022-08-13 Journal: PLoS Biology [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome coronavirus Affect both virus both viruses Cell culture characteristic clinical feature coronavirus coronavirus 2 CoV infection epithelial epithelial cell exhibit Host host cell host cell response host innate immune response dynamics human respiratory epithelium human-to-human transmission dynamics infected individuals Infection influence innate immune response interferon investigated Lower respiratory tract performed Phylogenetic relationship primary human airway primary human airway epithelial cell culture model pro-inflammatory response pro-inflammatory responses public health replicated Replication replication efficiency replication kinetics respiratory respiratory viruses SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2 and SARS-CoV infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Spread temperature temperature-dependent interferon These data time-resolved transcriptome analysis Transcriptome transcriptome analysis transmission efficiencies type I type III interferon upper respiratory epithelium upper respiratory tract Viral viral replication viral replication kinetics virus–host dynamics virus–host interaction dynamics viruses [DOI] 10.1371/journal.pbio.3001158 PMC 바로가기 [Article Type] Research Article
Recovering coronavirus from large volumes of water대량의 물에서 코로나바이러스 복구Article Published on 2021-03-252022-09-11 Journal: The Science of the total environment [Category] SARS, 치료기술, [키워드] both virus both viruses centrifugation Concentration Contamination coronavirus coronavirus disease COVID-19 dead demonstrated diarrhea Dilution enveloped virus epidemic diarrhea fiber filtration inhibitor limitation mengovirus methodology Occurrence overcome pandemic PCR PEDV Quantitative question resource RNA RT-qPCR SARS-CoV-2 Seawater sensitivity significant difference statistical surface Surface water tap tap water Tap water. viral particle Viral particles virus Volume water water cycle Water resources [DOI] 10.1016/j.scitotenv.2020.143101 PMC 바로가기 [Article Type] Article
ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species Research Published on 2021-03-012022-10-05 Journal: Nature Ecology & Evolution [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Analysis angiotensin-converting enzyme 2 bat bat ACE2 both virus both viruses cell lines Contact coronavirus coronavirus disease COVID-19 Critical Cross-species transmission functional Genetic Host host receptor Human human cell humans identify Infection infection assay Interaction knowledge no correlation orthologue pandemic phylogenetically Probability receptor Receptor binding residue reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection suggested Support susceptibility Variation viral entry viral spike protein [DOI] 10.1038/s41559-021-01407-1 [Article Type] Research
Morphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell culturesArticle Published on 2021-02-102022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] appear both virus Cell Cell culture complement COVID-19 disease Culture electron tomography Epidemiology Frankfurt globe infancy information isolates median Microscopy morphology particle size distribution SARS virus SARS-CoV SARS-CoV-2 SARS-CoV-2 particle spike spikes Spread the disease the SARS-CoV-2 Treatment Ultrastructural analysis Vero Cell virus was related while [DOI] 10.1038/s41598-021-82852-7 PMC 바로가기 [Article Type] Article
Characteristics of Patients Co-infected with Severe Acute Respiratory Syndrome Coronavirus 2 and Dengue Virus, Buenos Aires, Argentina, March–June 2020Synopsis Published on 2021-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Argentina both virus Buenos Aire Buenos Aires Clinical characteristics Co-infection cohort of patient coronavirus coronavirus 2 coronavirus disease Coronaviruses COVID-19 Dengue Dengue fever dengue virus died Epidemic febrile disease hospital Hospitalized Infection infection with SARS-CoV-2 intensive care laboratory data lymphopenia occur occurred outcome Patient Pneumonia Rash respiratory respiratory infections respiratory symptoms SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Symptom viruses zoonoses [DOI] 10.3201/eid2702.203439 PMC 바로가기 [Article Type] Synopsis
Screening for a Potential Therapeutic Agent from the Herbal Formula in the 4 th Edition of the Chinese National Guidelines for the Initial-Stage Management of COVID-19 via Molecular DockingResearch Article Published on 2020-12-222022-10-31 Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19, [키워드] ACE2 agent angiotensin-converting enzyme 2 anti-inflammatory effect Antiviral effect applied Atractylode AutoDock binding binding affinity both virus caused Chinese compounds country COVID-19 disease disrupt distribution docking eligible Formula GenBank guideline Herbal herbal compound identify in vitro study in vivo indicated interactions lung management material mechanism national guideline pathogenicity pharmacokinetic Potential predict predicted Protein provide Result SARS-CoV SARS-CoV-2 SARS-COV-2 infection Screening spike glycoprotein TCMSP therapeutic therapeutic agent Virus-host interactions was used [DOI] 10.1155/2020/3219840 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivoSARS-CoV-2 D614G 변이체는 생체 외에서 효율적인 복제 및 생체 내 전달을 나타냅니다.Report Published on 2020-12-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter angiotensin animal models Antisera appear both virus both viruses change Changing Characteristics China coronavirus D614G D614G substitution D614G variant dominant Effect Efficacy ENhance enzyme epithelial cell epithelial cells Ex vivo exhibit experiment faster glycine greater greater transmissibility hamster hamsters Human human Angiotensin-converting enzyme human cell human cells in vitro in vivo indicate infecting Infection maintain morphology Mutation neutralization Neutralizing new virus pandemic spread Pathogenesis pathogenicity Population prevalent primary human airway Primary human airway epithelial cells primary human cell primary human cells pulmonary disease replaced REPLACED BY replicate Replication respiratory respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant Science severe acute respiratory syndrome Coronavirus significantly Spike protein strain Strains susceptible the times These data transgenic mice Transmissibility Transmission vaccine candidate vaccine candidates variant variant of SARS-CoV-2 Viral viral pathogenesis viral spike protein viral titer virulence virus viruses wild-type virus [DOI] 10.1126/science.abe8499 PMC 바로가기 [Article Type] Report
COVID-19 and Liver Damage: Narrative Review and Proposed Clinical Protocol for Critically ill Pediatric PatientsReview Article Published on 2020-11-022022-10-31 Journal: Clinics [Category] COVID-19, MERS, SARS, [키워드] ALT/AST both virus C-reactive protein case sery Characteristics clinical coronavirus COVID-19 COVID-19 patient Critically ill CRP described direct viral infection Drug-induced liver injury exacerbated Follow-up genomic sequence histopathological impairment include Infection Inflammatory inflammatory markers Inflammatory response lesions liver Liver damage liver enzyme management MERS-CoV narrative Necrosis pathophysiological mechanism pediatric Pediatric case periportal pro-calcitonin protocol raised respiratory symptom retrospective cohort review SARS-CoV SARS-CoV-2 SARS-CoV-2 infections shown Surveillance syndrome the SARS-CoV-2 with COVID-19 [DOI] 10.6061/clinics/2020/e2250 PMC 바로가기 [Article Type] Review Article
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaborationResearch Article Published on 2020-10-262022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] ACE-2 ACE2 ACE2 receptor applied approach binding blocked blocking both virus Brain carbohydrate caused Cell cells changes complex COVID-19 CRISPR-Cas9 Critical disrupt domain evaluated examined experiment expressed expressing furin Genetic glycan glycans glycoprotein glycoscience glycosylated glycosylation HEK293T cells helping highlight Host host cells Human human kidney human protein illnesses infect Infectious disease inhibition inhibitor interfere kidney kifunensine Laboratory less Lungs modify post-translational modification Protein RBD receptor ACE2 reduce reduced Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 viral spike spike-ACE2 stick Structure sugar sugar molecule the Spike treat Treatment Vaccines viral entry virus [DOI] 10.7554/eLife.61552 PMC 바로가기 [Article Type] Research Article