Simultaneous Detection of RIG-1, MDA5, and IFIT-1 Expression Is a Convenient Tool for Evaluation of the Interferon-Mediated ResponseArticle Published on 2022-09-212022-11-15 Journal: Viruses [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] A549 cell acute phase assumed both virus clinical Course cytosolic cytosolic sensors detection disease onset Disease progression donors elevated evaluated expression Genes H3N2 immune response in vitro in vitro transcribed RNAs influenza A influenza A virus inhibit interferon-stimulated gene interferons ISGs MDA5 Mild-to-moderate mRNA expression mRNA level multiple mechanism multiplex not differ observation onset of symptoms pathogenesis of SARS-CoV-2 patients with influenza post infection qPCR qPCR assay remained response RNA RNAs SARS-CoV-2 SARS-CoV-2 patient Signaling Simultaneous SOCS-1 the disease transcribed transfected with type I virus White blood cell White blood cells worsening [DOI] 10.3390/v14102090 PMC 바로가기
SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesisArticle Published on 2022-09-132022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, [키워드] accessory gene Accessory genes accessory protein acute respiratory syndrome Affect Alter both virus cells characterized clinical disease clone contribute coronavirus COVID-19 pandemic Deletion driven by Effect ENhance evade Genome Host in vitro in vivo innate immune mouse Mutation pandemic Pathogenesis persists Protein public health crisis Receptor binding replaced Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 variant shown Signaling spike mutation Spread the spike protein Transmission Vaccine vaccine responses variant variant spike Viral variants virus viruses [DOI] 10.1073/pnas.2204717119 PMC 바로가기
Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell ModelsArticle Published on 2022-09-092022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] addressed Analysis Antiviral APOBEC APOBEC3G APOBECs approach both virus Caco-2 Caco-2 cell Caco-2 cells Calu-3 Calu-3 cell Calu-3 cell line Cell cell line cellular cellular response Colon commonality Course COVID-19 dataset determine differentially expressed gene disease Diseases epithelial cell events Evidence expressed genes expression pattern Factors feature gastrointestinal tract gene expression level gene signatures host response intrinsic liver lung lung; manifestation Model molecular outcome Pathomechanism Pathways performed Perturbation provide question Research Respiratory system response SARS-CoV SARS-CoV-2 similarity Systems biology the interferon tissue expression transcriptomic translational unique [DOI] 10.3390/ijms231810451 PMC 바로가기
Co-existence and co-infection of influenza A viruses and coronaviruses: public health challengesReview article Published on 2022-08-172022-10-05 Journal: The Innovation [Category] 비임상, [키워드] acute respiratory syndrome affecting aggravate Alter both virus caused circulation co-existence Co-infection coronavirus CoV CoVs Cross-species transmission disease disease transmission Evolution facilitate FIVE Genetic host range hosts Human IAV influenza A virus maintain Pandemics public health public health challenges Recombination risk SARS-CoV-2 Surveillance variant virus [DOI] 10.1016/j.xinn.2022.100306 [Article Type] Review article
Development of passive samplers for the detection of SARS-CoV-2 in sewage and seawater: Application for the monitoring of sewage하수 및 해수 내 SARS-CoV-2 검출을 위한 패시브 샘플러 개발: 하수 모니터링을 위한 응용Article Published on 2022-08-102022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] application both virus both viruses collected Concentration conducted coronavirus correlated determine development diarrhea epidemic diarrhea Epidemiology Evolution Frequency Genome immersion inactivated increase in influent membrane membranes no significant difference Norovirus Nylon Passive Passive samplers PEDV Polymer public health recent SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 genome Seawater sewage shown significant difference significantly higher the SARS-CoV-2 Treatment virus virus detection viruses wastewater Wastewater- seawater. water [DOI] 10.1016/j.scitotenv.2022.155139 PMC 바로가기 [Article Type] Article
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Comparison of Surface Persistence of SARS-CoV-2 Alpha and Delta Variants on Stainless Steel at 4°C and 24°C4°C 및 24°C에서 스테인리스강에 대한 SARS-CoV-2 알파 및 델타 변이체의 표면 지속성 비교Article Published on 2022-07-262022-09-11 Journal: Applied and Environmental Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Aerosols Alpha alpha and delta variants Alpha variant both virus both viruses conditions conducted contact with contaminated surface contaminated surfaces COVID-19 Delta delta variant detectable droplet Evidence fomites Human implication in some Intervention investigated log MOST occur persistence provide reduction reductions Region RNA RNA virus SARS-CoV-2 SARS-CoV-2 variants stability stainless steel steel Support surface surface persistence surface stability survival survived temperature through contact transfer Transmission transmission of SARS-CoV-2 variant winter transmission. [DOI] 10.1128/aem.00764-22 PMC 바로가기 [Article Type] Article
Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposingReview article Published on 2022-07-012022-10-05 Journal: Drug discovery today [Category] 신약개발, [키워드] active sites affecting AIDS binding both virus cause common drug complexes Diseases drug Drug development drug resistance drugs HBV hepatitis B virus polymerase HIV HIV-1 reverse transcriptase human liver immune system implication inhibitors L-nucleoside opportunity pathogen polymerase problem public health remained repurposing structures transcriptase virus with HIV [DOI] 10.1016/j.drudis.2022.02.016 [Article Type] Review article
Neutralizing Antibody Response to Sarbecovirus Is Delayed in Sequential Heterologous ImmunizationSarbecovirus에 대한 중화 항체 반응은 순차적 이종 면역화에서 지연됩니다Article Published on 2022-06-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect antigenic antigenic imprinting booster both virus coronavirus COVID-19 cross-reactive binding antibody Delayed Effectiveness Evidence Heterologous immune immune response immunization immunized include Influenza knowledge Neutralizing antibody response provide reported response SARS-CoV-1 SARS-CoV-2 Strains the antibody response therapeutic interventions Vaccine virus while [DOI] 10.3390/v14071382 PMC 바로가기 [Article Type] Article
Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging TherapiesSARS-CoV-2 감염 중 칼슘 신호: 새로운 치료법의 잠재력 평가Review Published on 2022-01-122022-09-11 Journal: Cells [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Assessing both virus both viruses Breakthrough infection breakthrough infections Ca2+ channels calcium Calcium signaling cascades cause Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cure described disease effort Health Organization Immune escape in viral Infection knowledge pandemic positive-sense single-stranded RNA Potential required Research respiratory Respiratory illness RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity of COVID-19 signal skepticism Spread target Therapeutic strategies Therapeutics Treatment Vaccine variant Viral viral infection viral infections virus viruses WHO World Health Organization [DOI] 10.3390/cells11020253 PMC 바로가기 [Article Type] Review