Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19Research article Published on 2021-06-292022-10-05 Journal: Cell Reports [Category] 유전자 메커니즘, [키워드] activated acute respiratory syndrome bystander CD127 contribute coronavirus COVID-19 Critical CXCR4 death distinctive feature Effect elevated Escalation fatal COVID-19 homeostatic Immunity immunopathology individual individuals with COVID-19 Inflammatory limit lung Mild Pathogenesis phenotypic feature predict proliferation promote proportion Regulatory T cell relative robust SARS-CoV-2 SARS-CoV-2-specific T cell severe coronavirus disease severe COVID-19 severity Support T cell T cell response T cells [DOI] 10.1016/j.celrep.2021.109414 [Article Type] Research article
Protocol for a cohort study of the impact of the COVID-19 pandemic on the rate and incidence of bystander cardiopulmonary resuscitation (CPR) after out-of-hospital cardiac arrestStudy Protocol Published on 2021-06-212022-10-29 Journal: Scandinavian Journal of Trauma, Resuscitation and [Category] Coronavirus, MERS, SARS, [키워드] aggregation analysed Analysis benefit blood flow bystander Bystander cardiopulmonary resuscitation Cardiac arrest Cardiopulmonary changes in cohort study collected Completeness Corona COVID-19 COVID-19 pandemic CPR Defibrillation dependent on Effect Epidemiology Factors incidence information linear maintain medical service Out-of-hospital cardiac arrest outcome pandemic Patient Poisson distribution protection protocol random registries retrospective cohort study supplementary material the patient [DOI] 10.1186/s13049-021-00890-6 PMC 바로가기 [Article Type] Study Protocol
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease종단 분석에 따르면 지연된 방관자 CD8+ T 세포 활성화와 초기 면역 병리로 인해 심각한 COVID-19와 가벼운 질병이 구별됩니다Article Published on 2021-06-082022-09-10 Journal: Immunity [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abnormality Abstract Activation Analysis analyzed Asymptomatic bystander bystander CD8+ T cell CD8 CD8+ cellular characterized clinical implications Cohort complement complex COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity cytokine Cytokines defined disease disease severities disease severity driven by group identify immune immune change immune changes immune defect immune pathology immune response immunopathology Immunophenotyping in some individual individuals infected individuals inflammatory factors Inflammatory responses interferon interleukin Kinetics longitudinal longitudinal analysis Mild Mild disease Necrosis oxidative phosphorylation pathological response pathology plasmablast response plasmablast responses recovery replacing response reveal RNA sequencing robust SARS-CoV-2 serum cytokine severe COVID-19 severe disease severity subsequent Symptom symptom onset systemic inflammation T cell TNF TNF-α Transcriptome Tumor tumor necrosis tumor necrosis factor underlie Viral Viral load [DOI] 10.1016/j.immuni.2021.05.010 PMC 바로가기 [Article Type] Article
COVID-19 and the Risk of Relapse in Multiple Sclerosis Patients: A Fight with No Bystander Effect?Research article Published on 2021-06-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] SARS, 유전자 메커니즘, [키워드] Analysis association attack bystander control group COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 severity Hospitalized incidence incidence rate independent likelihood lymphopenia memory cell Multiple multiple sclerosis no significant difference not different objective Patient patients with COVID-19 patients without COVID-19 Post-infection Relapse Relapsing-Remitting Multiple Sclerosis Result retrospective cohort study risk SARS-CoV-2 sclerosis was recorded [DOI] 10.1016/j.msard.2021.102915 [Article Type] Research article
SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human MicrogliaImmunology Published on 2021-04-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] addition Anomaly association axis bystander catastrophic CNS COVID-19 COVID-19 case declining deubiquitinase distress downstream dysfunction Exosome Exosomes explain expression gene product Host Host immune response Human Hyperactivation IFN-β immune cascade IRF9 knowledge microglia microRNA modify mRNA nervous Neuroinflammation neurological NF-κB Novel coronavirus infection organ pathway patients pro-inflammatory gene expression Protein provide regulate Replication SARS-CoV-2 shown Specific spike spike gene supported suppress syndrome System target target gene tissue TNFα transfected cell transported ubiquitin uninfected USP33 Vaccine Viral load virus [DOI] 10.3389/fimmu.2021.656700 PMC 바로가기 [Article Type] Immunology
Impact of COVID-19 on Out-of-Hospital Cardiac Arrest in SingaporeArticle Published on 2021-03-312022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] 95% CI adjusted odds ratio arrest Binary logistic regression bystander calculate cardiac Characteristics circulation Coronavirus disease 2019 COVID-19 CPR Emergency evaluate force Impact incidence indirect effect less males median age occurred Out-of-hospital cardiac arrest outcome pandemic Patient Primary outcome return of spontaneous circulation service Singapore used data was used [DOI] 10.3390/ijerph18073646 PMC 바로가기 [Article Type] Article
Impact of Coronavirus Disease 2019 on Out-of-Hospital Cardiac Arrest Survival Rate: A Systematic Review with Meta-AnalysisArticle Published on 2021-03-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval aerosol-generating procedure analyzed arrest bystander cardiac Cardiopulmonary Cardiopulmonary resuscitation caused circulation comparable coronavirus COVID-19 COVID-19 disease COVID-19 group COVID-19 patient COVID-19 patients CPR determine diagnosed FIVE Future Hospital admission hospital discharge Impact measure Meta-analysis neurological non-COVID-19 group non-COVID-19 patient Non-COVID-19 patients Odds ratio Out-of-hospital cardiac arrest outcome outcomes pandemic Patient performed Primary outcome raise reduce reported review SARS-CoV-2 secondary SHD substantial risk survival survival rate systematic review the SARS-CoV-2 Trial Viral transmission [DOI] 10.3390/jcm10061209 PMC 바로가기 [Article Type] Article
Endothelial Cells in Emerging Viral InfectionsCardiovascular Medicine Published on 2021-02-242022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] appear bystander Comorbidity component COVID-19 detect Deterioration detrimental diabetes disease dissemination dysregulated emerging infections Endothelial cell endothelial cells Endothelial dysfunction endothelial function Endothelium exacerbate facilitate feature functions Health highlight highly pathogenic host immune system hypertension immune response immune responses in viral infect Infection Inflammation Inflammatory Influenza virus life-threatening mechanism modulate obesity pathway regulate replicate respond SARS-CoV-2 second Severe case severe COVID-19 Support tissues Validity Vascular vascular dysfunction and damage vascular endothelial cell Vascular function Viral diseases viral infections virulence virus viruses [DOI] 10.3389/fcvm.2021.619690 PMC 바로가기 [Article Type] Cardiovascular Medicine
Thrombocytopenia in Virus InfectionsReview Published on 2021-02-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] adaptive immune system aggregation Antiviral bystander Cell circulation Coagulation coronavirus Evidence hantavirus HIV immune response increasingly infections Infectious disease Influenza lymphopenia mechanism mechanisms Mild myelosuppression outcome Pathogenesis Patient phagocytosis Platelet raise SARS-CoV-2 shown supported Symptom thrombocytopathy thrombocytopenia viral infection viral infections viral infectious disease virus virus infection viruses [DOI] 10.3390/jcm10040877 PMC 바로가기 [Article Type] Review
Aerial Transmission of the SARS-CoV-2 Virus through Environmental E-Cigarette Aerosols: Implications for Public Policies환경 전자담배 에어로졸을 통한 SARS-CoV-2 바이러스의 공중 전파: 공공 정책에 대한 시사점Commentary Published on 2021-02-032022-08-31 Journal: International Journal of Environmental Research an [Category] MERS, 치료제, [키워드] activities added Aerial bystander comparable Contagion coughing COVID-19 COVID19 decrease droplet emission estimate exposure to Face mask Face masks facemasks General population hour implication increase Intervention Mechanical mechanical ventilation mouth breathing pandemic Policy Prevent PROTECT Public recommendation Relative risk relative risks respiratory respiratory activity risk risk analysis SARS-CoV-2 Smokers smoking Standard deviation the SARS-CoV-2 vaping Ventilation [DOI] 10.3390/ijerph18041437 PMC 바로가기 [Article Type] Commentary