The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade장기간의 백신 유발 항SARS-CoV-2 면역 반응은 TNFα 차단으로 인해 양과 질이 저하됩니다.Article Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 백일해, 변종, 진단, 파상풍, [키워드] Activation acute respiratory syndrome alteration analysed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG anti-TNF-α appear Autoimmune Autoimmune diseases blockade bystander Cell changes in chronic inflammatory disease Cohort comparable Control coronavirus COVID-19 Decline drugs Effect Efficacy ELISA flow cytometry groups healthy humoral immune response IgG immune cell populations immune response immunoblot investigated less Live virus Necrosis Neutralization assay neutralize neutralizing antibody neutralizing capacity Older omicron Patient patients plasma Plasma cell recipient reduced response SARS-CoV-2 second vaccination significantly T cell subset titre TNF-α TNFα tumor necrosis factor inhibitors tumor necrosis factor-α vaccination Vaccine variants of concern virus VoC was increased while [DOI] 10.1002/jmv.28063 PMC 바로가기
Analytic modeling and risk assessment of aerial transmission of SARS-CoV-2 virus through vaping expirations in shared micro-environmentsArticle Published on 2022-11-012022-11-16 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 변종, [키워드] added aerosol Aerosol visibility affected baseline bystander Complete conditions Contagion coughing COVID-19 COVID-19 pandemic Effect Electronic cigarettes emission environmental factor environmental factors Evidence Face mask Face masks Factors implication knowledge lack lockdown measure mechanical ventilation new SARS-CoV-2 nuclei occur parameter Particle percentage preventive measure PROTECT respiratory activity respiratory droplet resulting risk Risk modeling risk of COVID-19 SARS-CoV-2 SARS-CoV-2 virus seeking significantly smoker smoking spread of COVID-19 theoretical risk Transmission transmission of SARS-CoV-2 Transport vaccination vaccination rates variants virus wearing face mask working hypothesis [DOI] 10.1007/s11356-022-20499-1 PMC 바로가기
Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 CoagulopathiesArticle Published on 2022-09-292022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] Adenovirus antibody antigenic antigenic complementarity antigens autoantibody Autoimmune Autoimmunity Bacteria Bacterial Bacterial infection binding constant Blood bystander bystander infection cardiolipin Clostridia coagulation factor Coagulopathies Coagulopathy Combination COVID-19 cross-reactive develop E. coli Escherichia coli Factor factor IX factor VIII function glycoprotein Human induced infections Interaction investigated involved Klebsiella pneumoniae moderate-to-severe COVID-19 MOST mRNA mRNA vaccine Mycobacterium tuberculosis Patient PF4 Platelet platelet factor 4 polyclonal antibody Protein Proteins recognize Research SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 proteins serum albumin similarity Staphylococcus Streptococcus stroke tested thrombocytopenia thrombosis thrombotic vaccine-induced thrombotic thrombocytopenia virus von Willebrand factor [DOI] 10.3390/ijms231911500 PMC 바로가기
COVID-19 and Guillain-Barré syndrome: A single-center prospective case series with a 1-year follow-upCOVID-19 및 Guillain-Barré 증후군: 1년 추적 관찰이 포함된 단일 센터 전향적 사례 시리즈Observational Study Published on 2022-07-292022-09-11 Journal: Medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antecedent antibody association bystander Case report case reports case sery cerebrospinal fluid clinical clinical feature Clinical presentations Clustering Computerized tomography consecutive patient coronavirus COVID-19 diagnosed disability feature Follow-up Guillain-barrè syndrome highlight hospital incidence Infection involved Italian Laboratory lack lymphopenia Medical Research Council Nasopharyngeal swab neurological Neurological diseases no difference no differences observational study pandemic patients patients with SARS-CoV-2 Pneumonia positive Prevalence Prognosis reduction Referral Region reported response to treatment retrospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severity single-center Spectrum subtype Support Swab syndrome systemic inflammation Temporal Treatment university Waves while X-ray [DOI] 10.1097/MD.0000000000029704 PMC 바로가기 [Article Type] Observational Study
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanismArticle Published on 2022-07-122023-07-09 Journal: Immunity [Category] COVID19(2023년), [키워드] bona fide bystander Influenza virus Lungs memory B cells respiratory infection SARS-CoV-2 [DOI] 10.1016/j.immuni.2022.06.002 PMC 바로가기
SARS-CoV-2 triggering autoimmune diseases자가 면역 질환을 유발하는 SARS-CoV-2Review Published on 2022-06-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acquired immunity Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS autoantibody autoimmune antibodies Autoimmune disease Autoimmunity autoreactivity bystander caused CD4 CD8 chronic inflammation contribute coronavirus COVID-19 COVID-19 pandemic cytokine cytokine secretion Cytokine storm element elicit Evidence high mortality Hyperactivation Hyperstimulation immune response immune system Immunity immunological Immunosuppression Inflammation mechanism molecular molecular interaction molecular mimicry pandemic Patient respiratory respiratory distress Respiratory distress syndrome respiratory epithelium SARS-CoV-2 scarcity self-tolerance severe acute respiratory syndrome Coronavirus syndrome T cells the disease thought Trigger triggering triggers variety virus viruses [DOI] 10.1016/j.cyto.2022.155873 PMC 바로가기 [Article Type] Review
The UK stand together trial: protocol for a multicentre cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of KiVa to reduce bullying in primary schoolsUK Stand Together Trial: 초등학교에서 괴롭힘을 줄이기 위한 KiVa의 효과와 비용 효율성을 평가하기 위한 다기관 클러스터 무작위 통제 시험 프로토콜Article Published on 2022-03-292022-09-11 Journal: BMC Public Health [Category] 임상, [키워드] 1:1 90% power Analysis assigned assumed baseline Bullying Burnout bystander Child child health children client Cluster Cluster randomised controlled trial commenced conducted Controlled trial cost-effectiveness COVID-19 pandemic Date East Economic evaluation effective Effectiveness emotional England evaluate Evidence evidence of Follow-up Frequency generate Health ICC identify implementation indicated influences influences on Intervention inventory ISRCTN KiVa mechanisms Mental mental health multicentre North Perspective Pragmatic Process process evaluation protocol public health questionnaire randomised randomised controlled randomised controlled trial receipt recruited reduce reducing reduction reported resulting Sample Sample size scalability School school attendance School intervention School meal Schools secondary Self-efficacy service significance level South stratified Trial Two-arm Violence prevention Violence prevention. Well-being West [DOI] 10.1186/s12889-022-12642-x PMC 바로가기 [Article Type] Article
Activation of Citizen Responders to Out-of-Hospital Cardiac Arrest During the COVID-19 Outbreak in Denmark 2020Observational Study Published on 2022-03-152022-10-05 Journal: Journal of the American Heart Association [Category] 임상, [키워드] Activation affected arrest bystander cardiac Cardiopulmonary circulation Citizen Responder Program COVID-19 COVID‐19 Defibrillation Denmark interquartile range Intervention lockdown not differ out‐of‐hospital cardiac arrest. performed Program psychologically Region reported Responder responders Result Ventilation [DOI] 10.1161/JAHA.121.024140 PMC 바로가기 [Article Type] Observational Study
Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patientsResearch article Published on 2022-02-272022-10-05 Journal: Molecular Therapy [Category] 치료제, [키워드] acute respiratory syndrome adoptive immunotherapy analyses approach Autoimmunity bystander convalescent Coronavirus-2 Course COVID-19 COVID-19 cases COVID-19 immunopathology CRISPR-Cas9 death Donor Efficiency efficient clearance flow cytometry high risk immune response immunopathology Immunosuppressed immunosuppressed patient Immunosuppression Immunotherapy increased risk Infection manifested Patient Prevent receive recipient recipients reduced ribonucleoprotein RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cell Sequencing severe coronavirus disease severe COVID-19 single-cell single-cell level solid organ Solid organ transplant recipients SOT SOT patient specificity T cell T cell activation T cell receptor T cell therapy TCR therapeutic transfer treat Vaccine Vaccines viral clearance viral infection [DOI] 10.1016/j.omtm.2022.02.012 [Article Type] Research article
Well-differentiated liver cancers reveal the potential link between ACE2 dysfunction and metabolic breakdown잘 분화된 간암은 ACE2 기능 장애와 대사 장애 사이의 잠재적 연관성을 보여줍니다Article Published on 2022-02-032022-09-10 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome coronavirus Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bile canaliculi bioinformatics bystander Cancer Cancer cells cancers Cell co-expression network coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 dataset DNA dysfunction endothelial cells enzyme Epigenetics analysis Express FIVE followed by functions Gene expression analysis Genomic analysis hepatic function hepatocytes High-resolution human liver Image analysis imaging immunohistochemistry Immunological techniques in vitro Inflammation liver Liver cancer Liver disease livers Localization Microarray Microscopy mRNA multiplex mutated oxidative stress POLE predicted promoter protein expression Quantitative receptor respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro Sequencing Serine serine protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 tissue TMPRSS2 TMPRSS2 expression transcriptomic transmembrane serine protease transmembrane serine protease 2 Tumor tumors Viral whole mount β-catenin [DOI] 10.1038/s41598-021-03710-0 PMC 바로가기 [Article Type] Article