Serum calprotectin is not an independent predictor of severe COVID-19 in ambulatory adult patients혈청 칼프로텍틴은 보행 가능한 성인 환자에서 중증 COVID-19의 독립적인 예측 인자가 아닙니다.Article Published on 2022-02-012022-09-11 Journal: The Journal of Infection [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] Abstract Biomarkers calprotectin COVID-19 Emergency emergency medicine independent Infection Patient severe COVID-19 Viral viral infection [DOI] 10.1016/j.jinf.2021.11.017 PMC 바로가기 [Article Type] Article
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)Observational Study Published on 2022-01-012022-10-05 Journal: Inflammation research : official journal of the Eu [Category] 임상, [키워드] Accuracy Activation Admission admitted to ICU adult COVID-19 patients Analysis blood sample calprotectin can be used characterized collected COVID-19 COVID-19 patients Critical dysregulated immune response evaluate ICU ICU admission ICU patient independent intensive care unit Intubated Invasive mechanical ventilation involved Laboratory tests multicenter neutrophil neutrophil activation Neutrophil activation. patients predict Primary outcome prospective observational study Prospective Study reflect required ROC AUC secondary outcome serum severe COVID-19 severe respiratory failure severity significantly higher [DOI] 10.1007/s00011-021-01516-4 PMC 바로가기 [Article Type] Observational Study
Prognostic value of circulating calprotectin levels on the clinical course of COVID-19 differs between serum, heparin, EDTA and citrate sample typesResearch article Published on 2022-01-012022-10-05 Journal: Clinica chimica acta; international journal of cli [Category] SARS, 바이오마커, [키워드] Analysis AUC AUROC Biomarker calprotectin circulating Clinical course clinician COVID-19 COVID-19 patient COVID-19 patients CRP Deceased defined discriminatory power EDTA help highest ICU admission IL-6 LDH material negative control outcome outperform Patient plasma populations pre-analytics predict procalcitonin Prognostic value Result SARS-CoV-2 SARS-CoV-2 pandemic serum severity of COVID-19 significantly higher [DOI] 10.1016/j.cca.2021.12.011 [Article Type] Research article
COVID-19 and gut immunomodulation코로나19와 장 면역 조절Review Published on 2021-12-142022-09-12 Journal: World journal of gastroenterology [Category] SARS, 진단, [키워드] acute respiratory syndrome Adaptive immune response addition angiotensin-converting enzyme-2 antibodies association calprotectin changes in clinically Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cytokines dependent on direct infection disease disease severity Dysbiosis epithelial cell expresse Gastrointestinal gastrointestinal symptoms GI symptom GI symptoms GI Tract Gut gut microbiota Health heterogeneous hypoxia immune immune activation immune response Immunity immunoglobulin A impairment in vitro in vivo infect infected individual Infection Innate innate immune response intestinal epithelium observation organ organoids outcome Pathogenesis Patient positive Pre-existing diseases Probiotic Proinflammatory cytokine protease Protein reported required respiratory problems respiratory symptom Respiratory system rhesus SARS-CoV-2 serine 2 severe COVID-19 patient severe respiratory illness severity Stool supported Symptom symptomatic patient the disease therapeutic interventions Therapeutics transmembrane Viral RNA virus [DOI] 10.3748/wjg.v27.i46.7925 PMC 바로가기 [Article Type] Review
Complement system component dysregulation is a distinctive feature of COVID-19 disease: a prospective and comparative analysis of patients admitted to the emergency department for suspected COVID-19 diseaseClinical Trial Published on 2021-12-142022-10-04 Journal: Journal of Thrombosis and Thrombolysis [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] activated Activation acute respiratory syndrome Analysis Antigen automated both groups C5a calprotectin classical pathway clinical Coagulopathy Cohort complement complement components complement system component control group coronavirus Coronavirus disease 2019 correlation COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient COVID-19 patients Data analysis diagnosis of COVID-19 dysregulation emergency department Laboratory lateral flow Level no difference pathophysiology Patient plasma positive Prospective trial Quantitative SARS-CoV-2 serum significantly higher supplementary material tested Vascular damage von Willebrand factor was determined were assessed were measured with COVID-19 [DOI] 10.1007/s11239-021-02617-x PMC 바로가기 [Article Type] Clinical Trial
Elevated fecal and serum calprotectin in COVID-19 are not consistent with gastrointestinal symptomsArticle Published on 2021-11-092022-10-04 Journal: Scientific Reports [Category] 바이오마커, 치료기술, [키워드] acute phase association Biochemistry Biomarkers calprotectin caused cell damage controls COVID-19 COVID-19 case COVID-19 disease COVID-19 patient diarrhea disease severity elevated epithelial fecal Gastrointestinal symptom GI symptom Health care healthy control healthy individuals immune system immunology inflammation marker Inflammatory marker Inflammatory response investigated manifestation median Medical research not correlated not significantly different performed progressed progression SARS-COV-2 infection serum subgroup thought triggered uninfected were measured [DOI] 10.1038/s41598-021-01231-4 PMC 바로가기 [Article Type] Article
Assessment of antiphospholipid antibodies and calprotectin as biomarkers for discriminating mild from severe COVID-19경증에서 중증 COVID-19를 구별하기 위한 바이오마커로서의 항인지질 항체 및 칼프로텍틴의 평가Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 바이오마커, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome antibodies antibody anticardiolipin antibodies anticardiolipin antibody antiphospholipid antibodies assessment association Biomarker C-reactive protein C-reactive protein (CRP calprotectin CD4 clinically coronavirus coronavirus disease correlation COVID-19 COVID-19 patient COVID-19 patients CRP CRP level CRP levels detectable Detection limit elevated ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated ferritin groups healthy control healthy controls help highest Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients IgM immunoassay IMPROVE Inflammatory laboratory parameter lymphocyte Lymphocyte count management Mild moderate multiplex negative correlation neutrophil Neutrophil-to-lymphocyte ratio no significant differences not differ outcome oxygenation status parameter pathway peak levels Prevalence procalcitonin proportion respiratory distress Respiratory distress syndrome sera severe COVID-19 severe group severity significant differences significantly significantly higher syndrome T cells two group two groups were measured [DOI] 10.1002/jcla.24004 PMC 바로가기 [Article Type] Article
Elevated Levels of Neutrophil Activated Proteins, Alpha-Defensins (DEFA1), Calprotectin (S100A8/A9) and Myeloperoxidase (MPO) Are Associated With Disease Severity in COVID-19 PatientsCellular and Infection Microbiology Published on 2021-10-212022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] addition alpha-defensin Analysis asymptomatic individual Biomarker calprotectin Clinical presentations comparable COVID-19 COVID-19 patient COVID-19 patients DEFA1 disease disease severity elevated healthy subject healthy subjects independent Level mechanical ventilation Mild mild patient MPO myeloperoxidase neutrophil onset of disease outcome Patient pro-inflammatory cytokine Prognostic markers Protein Proteins recovering patient reduced S100A8/A9 SARS-COV-2 infection Secondary infection secondary infections Serum level severity significantly higher therapeutic option through contact understanding [DOI] 10.3389/fcimb.2021.751232 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns중요한 COVID-19는 뚜렷한 백혈구 표현형 및 전사체 패턴과 관련이 있습니다Article Published on 2021-09-012022-09-11 Journal: Journal of internal medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] (PD-1 activated adaptive Admission affecting Alpha analysed B cells B-cell Bacterial sepsis Blood calprotectin CD25 CD4 CD8 T cells characterized classical monocytes cohort study collected comparable controls COVID-19 COVID-19 patient COVID-19 severity Critical disease disease severity Exhaustion exhibited expression flow cytometry groups healthy control healthy controls HLA-DR Hospitalization immune function immune functions Immune phenotype Immune profile immune response Immunity innate and adaptive immunity leukocyte marker monocyte Monocytes mononuclear cell mononuclear cells naïve Non-classical monocytes pathway Patient PBMCs PD-1 PD-L1 peripheral Peripheral blood Peripheral blood mononuclear cells phenotype plasma Prognostic markers Protein receptor reduced RNA sequencing SARS-CoV-2 Sepsis severity T cell T cells T-cell therapeutic target therapeutic targets these cell These cells transcript Transcriptome transcriptomic transcriptomics WHO guideline with COVID-19 [DOI] 10.1111/joim.13310 PMC 바로가기 [Article Type] Article
Calprotectin and SARS-CoV-2: A Brief-Report of the Current LiteratureBrief Report Published on 2021-07-292022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] assumption calprotectin can be used complement Complication complications contribute COVID-19 COVID-19 disease COVID-19 patient Critical current develop Disease activity evaluate fecal fecal calprotectin higher risk IBD Inflammatory intestinal intestine literature mechanism Mild MONITOR neutrophil activation Novel coronavirus outbreak Patient patients predict procoagulant status Prognosis progression SARS-CoV-2 serum severe disease Spread the disease Viral pneumonia Wuhan, China [DOI] 10.3390/healthcare9080956 PMC 바로가기 [Article Type] Brief Report