Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort studyChAdOx1 nCoV-19 및 BNT162b2를 사용한 동종 및 이종 프라임-부스트 면역의 안전성, 반응성 및 면역원성: 전향적 코호트 연구Observational Study Published on 2021-11-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] 95% CI Alpha anti-RBD Anti-RBD IgG Anti-S1 AstraZeneca B.1.1.7 B.1.351 Berlin Beta Beta variant beta variants binding BNT162b2 boost booster Cambridge ChAdOx1 ChAdOx1 nCoV-19 Concentration COVID-19 COVID-19 vaccines Cutoff dose education enrolled geometric mean Germany health-care Heterologous heterologous prime-boost highest homologous IFN-γ IgG levels immunisation immunogenicity IMPROVE inhibitory interim analysis IQR Mainz median mitigate neutralisation test participant Pfizer-BioNTech prospective cohort study prospective observational cohort pseudovirus neutralisation assay questionnaire RBD IgG RBD-ACE2 reactivity reactogenicity receiving recipient recipients regimen reported Safety SARS-CoV-2 S1 SARS-CoV-2 virus SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody second vaccination specific antibodies supply shortage Symptom systemic systemic symptoms T-cell vaccination Vaccine variants of concern was measured [DOI] 10.1016/S2213-2600(21)00357-X PMC 바로가기 [Article Type] Observational Study
Challenges of Storage and Stability of mRNA-Based COVID-19 VaccinesReview Published on 2021-09-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome Cambridge caused challenge coronavirus Coronavirus-2 country COVID-19 disease effective Emergency use ENhance global pandemic highly pathogenic Mainz Moderna MOST mRNA platform mRNA vaccine mRNA-based vaccine New York Pfizer Research RNA vaccine SARS-CoV-2 Spread stability storage temperature USA vaccination Vaccine Vaccines [DOI] 10.3390/vaccines9091033 PMC 바로가기 [Article Type] Review
Superspreaders drive the largest outbreaks of hospital onset COVID-19 infectionsResearch Article Published on 2021-08-242022-10-31 Journal: eLife [Category] COVID-19, MERS, [키워드] Algorithm applied build Cambridge caused Cluster collected COVID-19 infection COVID-19 pandemic determine develop effective events Factor finding First wave foundation generate Genetic genetic data genetic information genetic material global public health HCWs Health care worker help heterogeneity hospital Hospital wards Hospital-acquired infection hospitals IMPROVE incidence individual individuals infected individuals Infection infection control information Intensive measure NHS nosocomial Nosocomial transmission notable outbreak Patient provide provided recorded reduce reporting symptoms researcher Retrospective analysis Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission sequence sick Spread spreads superspreader swabbing Symptoms the epidemic the SARS-CoV-2 virus These data Transmission transmission of SARS-CoV-2 transmitted Trust university unlikely viral genome sequence Viral transmission virus virus spread vulnerable patient were infected [DOI] 10.7554/eLife.67308 PMC 바로가기 [Article Type] Research Article
Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trialArticle Published on 2021-08-042022-10-04 Journal: Nature Medicine [Category] 임상, [키워드] 95% CI adult outpatient age automated average Cambridge clinical trial diabete dialysis Efficacy End-stage renal disease evaluated event faster Glucose hypoglycemia insulin Insulin therapy IQR mean difference median men MONITOR occurred Open-label participant Patient primary endpoint proportion random Randomized reduced standard care therapy time Trial Trial registration type 2 diabete type 2 diabetes was reduced women [DOI] 10.1038/s41591-021-01453-z PMC 바로가기 [Article Type] Article
Cessation of Pulsed Lavage During the SARS-CoV-2 Pandemic: The Effect on Hip Hemiarthroplasty Cement MantlesOrthopedics Published on 2021-08-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] absolute increase acute respiratory syndrome aerosol-generating procedure association benefit bladder calculated Cambridge Cement clinician Cohen’s kappa coefficient coronavirus COVID-19 demonstrated detrimental detrimental effect Effect equipment Follow-up Guidance Hemiarthroplasty higher risk hip hip hemiarthroplasty hospital lavage Mantle Neck of femur fracture operative p value pandemic Pandemics Patient patients treated performed Personal protective equipment presenting Radiographic Result retrospective risk SARS-CoV-2 SARS-CoV-2-positive patients statistically significant the SARS-CoV-2 treated United Kingdom university was used [DOI] 10.7759/cureus.16809 PMC 바로가기 [Article Type] Orthopedics
Griffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral ModelCommunication Published on 2021-07-262022-10-30 Journal: Marine Drugs [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Analysis antagonistic effect Antiviral antiviral activity antiviral agent calculated Cambridge carrageenan Combination Concentration confirmed case coronavirus COVID-19 cytotoxicity death Diego evaluated exhibited GraphPad Prism half-maximal effective concentration identify Infection Iota lectins Model other coronavirus over polysaccharide Prevent reported Result SARS-CoV-1 SARS-CoV-1 and 2 SARS-CoV-2 SARS-CoV-2 mutations sulfated sulfated polysaccharides synergistic therapeutic treat USA was determined [DOI] 10.3390/md19080418 PMC 바로가기 [Article Type] Communication
Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 worldResearch Article Published on 2021-07-132022-10-31 Journal: eLife [Category] COVID-19, SARS, [키워드] activity Alliance ART authors BAL Cambridge center children Clinical research country Coverage Dame Data analysis data interpretation death Department development disease Diseases effective Fever Final foundation funding group had no Haemophilus influenzae hepatitis B human papillomavirus Impact Imperial College London Japanese encephalitis Johns Hopkins University LMICs London mathematical Mathematical modelling Medical Research Council Medicine Melinda Gate MRC Neisseria meningitidis occur Other Oxford pathogen Pennsylvania State University provide Public Health England Public health interventions receive Richard School Science Singapore Streptococcus pneumoniae Study design Support supported Travel unit university vaccination Vaccine Vaccine impact virus was used Washington [DOI] 10.7554/eLife.67635 PMC 바로가기 [Article Type] Research Article
Methodological Analysis: Randomized Controlled Trials for Pfizer and Moderna COVID-19 Vaccines방법론적 분석: Pfizer 및 Moderna COVID-19 백신에 대한 무작위 대조 시험Article Published on 2021-07-012022-09-11 Journal: Journal of pediatric health care : official public [Category] SARS, 임상, [키워드] Analysis appraisal Cambridge Care Casp CASP critical appraisals checklist checklist Community conducted Controlled coronavirus COVID-19 COVID-19 disease critical appraisal determine develop distribution Efficacy Health Health care item methodology Moderna morbidity and mortality MOST New York outcome Pfizer Population populations positive question Randomized randomized control trial Randomized controlled trial Randomized controlled trials RCT RCTs reduce Reporting reporting guidelines. rigor rigorous analysis scored skill Standard the vaccine Vaccinations Vaccine Vaccine hesitancy [DOI] 10.1016/j.pedhc.2021.04.001 PMC 바로가기 [Article Type] Article
COVID-19 Vaccination-Induced Rash: Does the Choice of Vaccine Matter?Dermatology Published on 2021-06-072022-10-31 Journal: Cureus [Category] COVID-19, [키워드] absolute eosinophil count approach AstraZeneca Brooklyn Cambridge Case series choice clinical information clinician coronavirus disease COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines develop drug rash Fever Germany healthcare policies Inc. incidence individual injection local inflammation maculopapular rashe Mainz Mild moderate Pain pandemic Pfizer Pfizer-BioNTech provided rashe receiving Side effect Side effects Symptom the vaccine vaccination Vaccinations widespread [DOI] 10.7759/cureus.15490 PMC 바로가기 [Article Type] Dermatology
Experiences of a “COVID protected” robotic surgical centre for colorectal and urological cancer in the COVID-19 pandemicCOVID-19 대유행에서 결장직장암 및 비뇨기과 암에 대한 "COVID 보호" 로봇 수술 센터의 경험Original Article Published on 2021-02-112022-09-12 Journal: Journal of Robotic Surgery [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] benefit Cambridge Cancer Colorectal surgery coronavirus COVID COVID-19 COVID-19 pandemic Elective surgery experience histology hospital increased risk initial instance less mitigate National outcome pandemic Patient recommendations rectal cancer reduced renal renal surgery Safe surgical Transmission United Kingdom Urology USA [DOI] 10.1007/s11701-021-01199-3 PMC 바로가기 [Article Type] Original Article