SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid dropletsResearch Article Published on 2021-11-222022-10-31 Journal: Febs Letters [Category] COVID-19, [키워드] A549 A549 cell approach association biological processe blocked cancer cell Cancer cells cells droplet epithelial exhibited G3BP1 G3BP2 Heat shock human lung interact Interaction investigated liquid–liquid phase separation mitoxantrone N protein NCAP nucleocapsid nucleocapsid protein oxidative oxidative stress PKR Protein provide RNA RNA degradation RNase SARS‐CoV‐2 SARS‐CoV‐2 SILAC Stress stress granule stress granules translocated Treatment undergo USP10 viral factory viral infection YTHDF3 [DOI] 10.1002/1873-3468.14229 PMC 바로가기 [Article Type] Research Article
Genome‐scale metabolic modelling of SARS‐CoV‐2 in cancer cells reveals an increased shift to glycolytic energy production암세포에서 SARS-CoV-2의 게놈 규모 대사 모델링은 해당 에너지 생산으로의 증가된 이동을 보여줍니다Research Letter Published on 2021-09-052022-09-10 Journal: Febs Letters [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alteration Cancer cancer cell Cancer cells cancer patient Cancer patients complementary conjunction COVID‐19 COVID‐19 cytokine cytokine secretion effective fatty Fatty acid flux balance analysis genome‐scale metabolic modelling Interaction metabolism multi‐omics pathway respiratory resulting reveal risk RNA SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Treatment strategies triggered Viral viral invasion [DOI] 10.1002/1873-3468.14180 PMC 바로가기 [Article Type] Research Letter
Exploring the cytotoxic mechanisms of Pediocin PA-1 towards HeLa and HT29 cells by comparison to known bacteriocins: Microcin E492, enterocin heterodimer and Divercin V41Research Article Published on 2021-09-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, SARS, [키워드] activate Apoptosis apoptotic bioinformatic analysis Cancer cells Cancer patients Cell cell death cells COVID-19 pandemic cytotoxicity dose Evidence exhibit experiment explain expression greater Hela highest highlight homology IMPROVE information interact lab mechanism Microcin potential mechanism Research sequence Sequence analysis shown TLR TLRs translated Treatment [DOI] 10.1371/journal.pone.0251951 PMC 바로가기 [Article Type] Research Article
Do Anti-androgens Have Potential as Therapeutics for COVID-19?항안드로겐이 COVID-19 치료제로 가능성이 있습니까?Article Published on 2021-08-012022-09-11 Journal: Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acting Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification androgen Androgen receptor androgens angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-androgen anti-androgens attachment Cancer cells Cell cells characterized cleavage clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Deprivation exhibiting expression followed by Gender glycoprotein Hospitalization Hypothesis increase infect Infection limitation lung male men mitigate molecular mortality rate offer patients Perspective Potential Prostate cancer protease receptor Recognition reducing responsible SARS-CoV-2 Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity Sex sex differences spike glycoprotein Spike protein susceptibility Testosterone Therapeutics therapy TMPRSS2 TMPRSS2 expression transmembrane transmembrane protein viral spike virus women [DOI] 10.1210/endocr/bqab114 PMC 바로가기 [Article Type] Article
MUC1-C influences cell survival in lung adenocarcinoma Calu-3 cells after SARS-CoV-2 infectionMUC1-C는 SARS-CoV-2 감염 후 폐 선암종 Calu-3 세포의 세포 생존에 영향을 미칩니다Article Published on 2021-08-012022-09-11 Journal: BMB reports [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adverse outcome adverse outcomes C-terminal Calu-3 Calu-3 cell cancer cell line Cancer cells Cell cells contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Defense expression growth induce influence inhibition investigated lung adenocarcinoma lung cancer lung cancer patients lung epithelial MUC1 mucin not affected pathogen Protein protein level protein levels reduced report respiratory respiratory tract risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT3 subunit survival Trigger [DOI] 10.5483/BMBRep.2021.54.8.018 PMC 바로가기 [Article Type] Article
Exosome-Based Vaccines: History, Current State, and Clinical Trials엑소좀 기반 백신: 역사, 현재 상태 및 임상 시험Review Published on 2021-07-142022-09-11 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] Biological functions Cancer cancer cell Cancer cells cell proliferation cell type cell types clinical clinical trial conducted coronavirus coronavirus disease current dendritic cell dendritic cells Diseases Evidence EVs example Exosome Exosomes Extracellular vesicles extracellular vesicles (EV) history immune response immune responses immunization implicated induce Infectious diseases Inflammation management mechanism mediation molecules Pathogenesis Perspective recent released shown state target Therapeutic strategies Therapeutics Treatment Usage vaccination Vaccine Vaccines Vesicle [DOI] 10.3389/fimmu.2021.711565 PMC 바로가기 [Article Type] Review
Role of Extracellular Vimentin in Cancer-Cell Functionality and Its Influence on Cell Monolayer Permeability Changes Induced by SARS-CoV-2 Receptor Binding DomainArticle Published on 2021-07-122022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] activated macrophages Activation activation pathway addition Alter angiotensin-converting enzyme 2 Astrocyte Bacterial bind binding binding domain Cancer Cancer cells cancer progression Cell Cell migration cells cellular change cytoskeletal domain Effect ENhance Extracellular extracellular space extracellular vimentin functional functions growth IGF-1 IGF-1 receptor induced Inflammation influence investigated involved MCF-7 Migration modulate modulation monolayer monolayers neutrophil infiltration overexpressed permeability physiological conditions proliferation promote Protein receptor Receptor binding domain reduced reduction role SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 receptor SARS-COV-2 receptor binding domain SARS-CoV-2 spike protein secreted shown Spike protein Support surface the SARS-CoV-2 Treatment vimentin viral infection while [DOI] 10.3390/ijms22147469 PMC 바로가기 [Article Type] Article
Organoids to Dissect Gastrointestinal Virus–Host Interactions: What Have We Learned?Review Published on 2021-05-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Affect animal models biologic biopsy Cancer cells cell type Clinical data complex interaction Culture diarrhea enteric virus enteroid Gastrointestinal Gastrointestinal infection heterogenous host–virus interactions human infection human infections human intestinal organoid Interaction intestinal intestinal epithelium intestinal organoid intestinal stem cell knowledge lack multicellular New Organoid outcome pathogen produced Replication surgical specimen Transwell® villus viral pathogens virus [DOI] 10.3390/v13060999 PMC 바로가기 [Article Type] Review
DHODH and cancer: promising prospects to be exploredReview Published on 2021-05-102022-10-31 Journal: Cancer & Metabolism [Category] COVID-19, [키워드] association Cancer Cancer cells Cancer metabolism Cancer therapy de novo De novo pyrimidine biosynthesis DHODH DHODH inhibitors dihydroorotate dehydrogenase disease Effect enzyme Evidence Human inhibitor mechanism Mitochondria mitochondrial multiple sclerosis pathway rheumatoid arthritis therapeutic target Therapies Treatment Tumor tumor progression [DOI] 10.1186/s40170-021-00250-z PMC 바로가기 [Article Type] Review
The Interference between SARS-CoV-2 and Tyrosine Kinase Receptor Signaling in Cancer암에서 SARS-CoV-2와 티로신 키나제 수용체 신호 전달 간의 간섭Review Published on 2021-05-022022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] accelerate activated addition approach Cancer cancer cell Cancer cells cell proliferation Characteristics clinically coronavirus correlation COVID-19 Critical diagnosed division downstream downstream signaling pathways drug Drug repurposing dysregulation dysregulations EGFR help identify infection rate information interact interfere Interference Invasion kinase management mechanism MERS metabolism pandemic pathogen Pathways Patient phenotypic produced receptor repurposing required Research research and development resource SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 Scientific community signaling pathway signaling pathways strongly related Structure therapeutic agent therapeutic agents Therapeutic compounds treat Treatment tyrosine tyrosine kinase tyrosine kinase receptor Viral viral infection Viral vector virus viruses [DOI] 10.3390/ijms22094830 PMC 바로가기 [Article Type] Review