SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation예방 접종 또는 감염 후 유도된 SARS-CoV-2 스파이크 및 핵단백질 특이적 항체는 고전적 보체 활성화를 촉진합니다Article Published on 2022-07-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] activated Activation antibodies antibody Antibody responses Antigen binding C1q C1q binding C3b cascade classical classical pathway complement Complement activation Complement cascade complement components Complement pathway component components convalescent COVID-19 COVID-19 patient COVID-19 patients deposition disease status downstream Effect ELISA assay groups hospitalised IgG1 induced median N antigen NHC non-hospitalised non-infected not differ nucleocapsid presence of antibody protective role Protein Protein binding response responses SARS-CoV-2 SARS-CoV-2 antigens SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera severe COVID-19 specific antigen spike spike glycoprotein subject the disease vaccination Vaccine vaccinees Variability Viral Viral antigen viral antigens [DOI] 10.3389/fimmu.2022.838780 PMC 바로가기 [Article Type] Article
Mutational cascade of SARS-CoV-2 leading to evolution and emergence of omicron variant오미크론 변이체의 진화와 출현으로 이어지는 SARS-CoV-2의 돌연변이 캐스케이드Article Published on 2022-07-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] Alpha Analysis cascade COVID-19 D614G Delta emergence events Evolution followed by Genome genomes GISAID H655Y Lambda majority Mutation mutations non-structural protein Non-synonymous Non-synonymous mutation NSP, non-structural protein nucleocapsid protein omicron Omicron variant ORF6 P681H performed Phylogeny RdRP rdrp, RNA dependent RNA polymerase. Repository RNA RNA dependent RNA polymerase RNA polymerase SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2, COVID-19, genome-wide, evolution, variants, VOC, VOI, VUM, SNP, mutation, non-synonymous, silent mutation, spike, RNA dependent RNA polymerase, NSP, UTR: Abbreviations: VOC, variant of co silent SNP specific clade Transmissibility untranslated region UTR UTR, untranslated region variant variant of SARS-CoV-2 variants variants of concern VoC VOI, variant of interest VUM, variant under monitoring while whole genome [DOI] 10.1016/j.virusres.2022.198765 PMC 바로가기 [Article Type] Article
Impaired Kallikrein-Kinin System in COVID-19 Patients’ SeverityObservational Study Published on 2022-06-222022-10-05 Journal: Frontiers in Immunology [Category] 임상, [키워드] Accuracy ACE2 Admission analyzed Bradykinin (BK) C1 esterase inhibitor cascade characterized clinical laboratory Coagulation Combination Concentration consecutive patient control group COVID-19 CPN1 cutoff value D-dimer D-dimer level disease disease severity dysregulated dysregulation enzyme Factor healthy subject ICU ICU admission Impaired independent independent predictor Inflammation intensive care involved Kallikrein-kinin system KLKB1 lymphopenia multivariate multivariate logistic regression multivariate model NLRP3 NLRP3 inflammasome Observational cohort study Odds ratio pathophysiology patients with COVID-19 peptide plasma concentration plasma protein Protein reported retained Severe COVID-19 pneumonia severity subunit System Thromboinflammation vascular homeostasis was related [DOI] 10.3389/fimmu.2022.909342 PMC 바로가기 [Article Type] Observational Study
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
Inflammasome activation in infected macrophages drives COVID-19 pathology감염된 대식세포의 인플라마좀 활성화는 COVID-19 병리를 유발합니다Article Published on 2022-06-012022-09-12 Journal: Nature [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] ACE2 receptors activate Activation antibody attenuate blockade blocking cascade CD16 characterized contributing to COVID-19 COVID-19 pathology Critical disease downstream host infection Human immune system human macrophage humanized hyperinflammatory state IFN IL-1 IL-18 immune in vivo Infection Infectious virus Inflammasome inflammasome activation inflammasomes Inflammatory cytokine inflammatory cytokine production inflammatory macrophages Inflammatory response interferon Lung inflammation Lung pathology Lungs Macrophage macrophages NLRP3 inflammasome overactive pathology pathway Prevent pyroptosis Remdesivir Replication required SARS-CoV-2 SARS-COV-2 infection Stage sustained undergo viral replication Viral RNA [DOI] 10.1038/s41586-022-04802-1 PMC 바로가기 [Article Type] Article
Target-triggered cascade signal amplification for sensitive electrochemical detection of SARS-CoV-2 with clinical application임상 적용과 함께 SARS-CoV-2의 민감한 전기화학적 검출을 위한 표적 트리거 캐스케이드 신호 증폭Article Published on 2022-05-222022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification Analysis applied cascade Cascade signal amplification catalytic catalyzed clinical sample clinical samples complex coronavirus COVID-19 COVID-19 diagnosis Detection limit diagnosis of COVID-19 disease DNA early stage effective electrochemical biosensor electrostatic interaction generate Health high stability incorporation Interference linear Lower outbreak Pandemics Prevent random RNA Saliva SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus simple Spread target targets [DOI] 10.1016/j.aca.2022.339846 PMC 바로가기 [Article Type] Article
Individual-Level Evaluation of the Exposure Notification Cascade in the SwissCovid Digital Proximity Tracing App: Observational StudyObservational Study Published on 2022-05-192022-10-04 Journal: JMIR Public Health and Surveillance [Category] COVID19(2023년), SARS, 임상, [키워드] addition app cascade complement complementary Compliance Contact Contact tracing Controlled COVID-19 Digital digital proximity tracing DPT Effect Effectiveness effort enrolled Epidemiology evaluate Evaluation Evidence exposure Factor had more highlight influence measure mHealth Mild-to-moderate Mobile App notification number Observational Observational cohort study pandemic participant proportion provide public health question Questionnaires receiving registry reported SARS-CoV-2 shown Standard stratified subsequent Surveillance SwissCovid Switzerland Symptom tested tracing tracking transmission of SARS-CoV-2 triggered used data [DOI] 10.2196/35653 PMC 바로가기 [Article Type] Observational Study
Palmitoylethanolamide (PEA) Inhibits SARS-CoV-2 Entry by Interacting with S Protein and ACE-2 Receptor팔미토일에탄올아미드(PEA)는 S 단백질 및 ACE-2 수용체와 상호작용하여 SARS-CoV-2 진입을 억제합니다Article Published on 2022-05-172022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 activate activated adjuvant therapy Antiviral antiviral agent antiviral drug antiviral drugs antiviral potency binding bioactive lipids cascade cause cellular clinical test Clinical tests clinical trial connection Coronaviruses counteract Course COVID-19 COVID-19 pandemic Degradation derangement Disruption drop droplets energy entry receptor event Evidence fatty Fatty acid generate glycoprotein Glycoproteins highlight Huh-7 cells humans in viral Infection Inflammation inflammatory stimuli lack life cycle Lipid lipid droplets lipid metabolism lipids mechanism of action mechanisms membrane metabolism nutraceutical palmitoylethanolamide Pathways PEA Prevent protective effect Protective effects recent replicate Replication Research RNA virus S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S protein second significantly Spike protein the SARS-CoV-2 therapy Toxicity transcription factor Treatment Usage viral infection viral life cycle virus viruses VSV [DOI] 10.3390/v14051080 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamstersArticle Published on 2022-05-092022-10-04 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome amplified benefit cascade cause circulating pro-inflammatory cytokine Complication complications of COVID-19 coronavirus COVID-19 COVID-19 patients COVID19 Cytokine dysregulation Effect evaluated Extrapulmonary hamster hamsters increasingly induce Infection Inflammatory inflammatory disease information less Long-term follow-up metabolism organ system pathogenesis of SARS-CoV-2 Patient pro-inflammatory Prophylactic respiratory tract SARS-CoV-2 SARS-COV-2 infection skeletal therapeutic intervention tissue tissues vertebrae viral infection [DOI] 10.1038/s41467-022-30195-w PMC 바로가기 [Article Type] Article
Improvements in Severe Acute Respiratory Syndrome Coronavirus 2 Testing Cascade in the United States: Data From Serial Cross-sectional Assessments미국의 중증급성호흡기증후군 코로나바이러스 2 검사 캐스케이드 개선: 연속 횡단면 평가 데이터Article Published on 2022-05-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus assessment barriers cascade Clinical management conducted Containment coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical cross-sectional demographics diagnostic diagnostic test diagnostic testing Early detection improvement Infection mass vaccination Massachusetts North participant remained reported respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly more South Surveillance Symptom Symptoms tested Testing the SARS-CoV-2 trends turnaround time turnaround times vaccination Variability variants wait times. [DOI] 10.1093/cid/ciab683 PMC 바로가기 [Article Type] Article