CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performanceResearch Article Published on 2020-09-022022-10-31 Journal: eLife [Category] Coronavirus, [키워드] allele caused CD163 coronavirus coronavirus Coronavirus infections CRISPR/Cas9 cross diarrhea Diseases disorder effective Epidemics Evidence exhibited experiment gastroenteritis Genotype healthy help Host host’s cell humans illnesses in vivo infect infect cells Infection infection mechanism knowledge no difference offer pathogenic virus PDCoV pig Porcine deltacoronavirus Premature Prevent produced producing Protein PRRSV receptor protein receptors reduce remained reproductive respiratory virus Safe sick starting point Stillbirth susceptibility syndrome TGEV traits virus virus viruses were infected wild-type [DOI] 10.7554/eLife.57132 PMC 바로가기 [Article Type] Research Article
Analysis of Swine Conventional Dendritic Cells, DEC205 + CD172a +/− CADM1 + , from Blood and Spleen in Response to PRRSV and PEDVArticle Published on 2019-10-312022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation autologous Blood CADM1 CD163 CD3 CDC Cell cells coculture Conventional cytokine production cytokine response DEC205 dendritic cell dendritic cells ELISA epidemic diarrhea evaluated expression IFN-γ IL-10 IL-12 IL-4 immune response incubated induce Infection low expression monocyte mononuclear cell naïve T cells naïve naïve T cell naïve T cells PBMCs PEDV Peripheral blood phenotype Population produced proliferation PRRSV qPCR reproductive respond response syndrome T cells transcript virus [DOI] 10.3390/v11111001 PMC 바로가기 [Article Type] Article
Direct Interaction Between CD163 N-Terminal Domain and MYH9 C-Terminal Domain Contributes to Porcine Reproductive and Respiratory Syndrome Virus Internalization by Permissive CellsOriginal Research Published on 2019-08-062023-08-30 Journal: Frontiers in Microbiology [Category] E형 간염, [키워드] CD163 MYH9 protein–protein interaction PRRSV virus internalization [DOI] 10.3389/fmicb.2019.01815 PMC 바로가기 [Article Type] Original Research