Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory Research Published on 2022-03-212022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome Antibody titers Antigen CD38 CD4+ T cell CD4+ T cells Cell circulating contribute coronavirus elicit exhibited expressing follicular iCoS increase in induce Infection memory Memory responses Neutralizing antibodies overlap phenotype populations Primary infection recall recalled receptor response robust SARS-CoV-2 SARS-CoV-2 spike secondary T cell the spike protein vaccination vaccine dose [DOI] 10.1038/s41590-022-01175-5 [Article Type] Research
SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes with implications for booster strategiesSARS-CoV-2 감염 및 백신 접종은 부스터 전략에 영향을 미치는 수명이 긴 B 및 CD4+ T 림프구를 유발합니다Article Published on 2022-03-152022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Adaptive immunity anti-spike immunity antibody antibody levels booster booster dose booster injection breakthrough infections causative agent CD4+ T cell CD4+ T cells CD4+ T lymphocyte Cellular immune response cellular immunity clinical clinical medicine Cohort CoV COVID-19 COVID-19 infection decay Department detectable Florence funds humoral humoral and cellular immunity Humoral immunity immune response Immunological memory implication individual individuals infected individuals Infection injection Italian Longitudinal evaluation Medicine memory B memory cell Memory cells Ministry of Health mRNA vaccination naïve individuals natural infection neutralization capacity occur performed persistence PROTECT reduced Reinfection restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2-infected individuals severe disease significantly Spike protein supported T cells Tuscany university vaccinated individual vaccinated individuals vaccination [DOI] 10.1172/JCI157990 PMC 바로가기 [Article Type] Article
T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death북아프리카 COVID-19 환자의 혈액 내 T 세포 수와 IL-6 농도는 심각한 질병 및 사망에 대한 두 가지 독립적인 예후 인자입니다Article Published on 2022-01-012022-09-11 Journal: Journal of leukocyte biology [Category] 바이오마커, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition African Analysis B cells Blood CD4+ T cells CD8+ T cell CD8+ T cells characteristic clinician Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 patient COVID-19 patients cutoff value cytokine cytokine level cytokine levels Cytokines death death group develop disease flow cytometry healthy control healthy controls help high risk IL-10 IL-6 immune parameter immune system independent investigated lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes Mild Mortality multivariate logistic regression multivariate logistic regression analysis natural killer cell Natural killer cells North outcome parameter pathology Patient patients percentage percentages performed Peripheral blood peripheral blood lymphocyte predict Prognosis Prognostic factor receiver operating characteristic respiratory risk ROC ROC curves SARS-CoV2 severe acute respiratory syndrome Coronavirus severe cases severe disease severity severity of illness significant difference significant differences significantly higher statistical difference statistical differences subset survival T cell T cells Th17 Th2 the disease the patient threshold Total two group two groups [DOI] 10.1002/JLB.4COVA1020-703R PMC 바로가기 [Article Type] Article
The pigtail macaque ( Macaca nemestrina ) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of diseaseCOVID-19의 돼지꼬리원숭이(Macaca nemestrina) 모델은 다양한 임상 결과를 재현하고 질병의 새롭고 복잡한 징후를 나타냅니다.Research Article Published on 2021-12-202022-09-10 Journal: PLoS Pathogens [Category] 변종, 진단, [키워드] animal animal model animal models approach Blood Cardiovascular Symptoms causative agent CD4+ CD4+ T cell CD4+ T cells CD8 claimed Clinical outcome Coagulation Cohort complex COVID-19 COVID-19 disease COVID-19 pandemic Critical disease drug Effective vaccines euthanized exhibited Express feature FIVE human disease humans immune Increases increases in Infection infection with SARS-CoV-2 Inflammatory lesions less macaque manifestation marker mechanism Mild-to-moderate Neutralizing antibodies Novel coronavirus novel coronavirus SARS-CoV-2 Pathogenesis pathologic Pigtail pulmonary pulmonary infiltrates respiratory respiratory viral reveal rising SARS-COV-2 infection SARS-CoV-2 viral severe COVID-19 disease severe disease severe disease course simian immunodeficiency virus SIV span Symptom T cell T cells tested Therapeutics transmissible variant transmissible variants treat Vaccine Viral viral dynamics viruses with infections [DOI] 10.1371/journal.ppat.1010162 PMC 바로가기 [Article Type] Research Article
Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients경증 COVID-19 환자에서 공개 cTfh 클론형을 확장하는 보존된 SARS-CoV-2 스파이크 에피토프 식별Article Published on 2021-12-062022-09-11 Journal: The Journal of Experimental Medicine [Category] MERS, SARS, 변종, 진단, [키워드] activate activated T cell activated T cells activating Adaptive immunity Antigen booster CD4+ T cell CD4+ T cells Cell characterized circulating commensal bacteria conserved COVID-19 epitope Epitopes expand follicular healthy donors HLA identification mild COVID-19 patient mild symptoms Patient prevalent Protective protective antibodies SARS-CoV-2 epitopes SARS-CoV-2 S SARS-CoV-2 spike subset T cell T cells TCR TCRs Tfh Tfh cell Tfh cells the SARS-CoV-2 variants [DOI] 10.1084/jem.20211327 PMC 바로가기 [Article Type] Article
SARS-CoV-2 and the Immune Response in Pregnancy with Delta Variant ConsiderationsReview Published on 2021-11-302022-10-30 Journal: Infectious Disease Reports [Category] COVID-19, [키워드] accumulate ACE2 binding CD4+ T cells CDC cells changes in circulation Combination complement concerning confirmed case contagious COVID-19 COVID-19 infection COVID-19 vaccination death Delta delta variant Effect eight elevated enzyme equity Evidence exacerbate Factor General population granulocyte greater host cell host cells hyperinflammatory state ICU admission IL-6 immune clearance immune response immunological immunomodulatory property imperative include increase in increases in infecting initial literature review Lung injury Monocytes morbidity natural killer neutrophil NICU admission Other consideration Patient phagocytic plasmacytoid dendritic cell Pregnancy pregnant pregnant women Preterm birth progesterone Proinflammatory cytokine proportion Regulatory T cell Respiratory system response SARS-CoV-2 SARS-COV-2 infection severe disease course significantly strain susceptibility susceptible Th1 TLR-7 TNF-α vaccination Vaccine Viral load virus Volume [DOI] 10.3390/idr13040091 PMC 바로가기 [Article Type] Review
CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody LeronlimabCCR5 수용체 점유 분석 결과 항-CCR5 항체 레론리맙 치료 후 말초혈액 CCR5+CD4+ T 세포 증가Clinical Trial Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] 임상, 진단, [키워드] antibody assays binding blockade Blood cancer progression CCR5 CD4 CD4+ T cell CD4+ T cells Cell circulating comparable Complete correlated Critical Defense Efficacy facilitate flow cytometric flow cytometry HIV Host Human humans immunological Impact in vivo increase in Increased independent Infectious disease lack macaque macaques Occupancy pathophysiological peripheral Peripheral blood plasma plasma concentration Receptor occupancy receptor occupancy (RO) resulting sensitivity statistically significant suppressed T cell therapeutic Treatment viral replication Viremia Weekly with HIV [DOI] 10.3389/fimmu.2021.794638 PMC 바로가기 [Article Type] Clinical Trial
T follicular helper cells in the humoral immune response to SARS‐CoV‐2 infection and vaccinationReview Published on 2021-11-032023-06-14 Journal: Journal of leukocyte biology [Category] COVID19(2023년), MERS, SARS, [키워드] CD4+ T cells COVID‐19 SARS‐CoV‐2 T follicular helper cells [DOI] 10.1002/JLB.5MR0821-464R PMC 바로가기 [Article Type] Review
Association of lymphocyte subsets with mortality in severe COVID‐19 pneumonia patients중증 COVID-19 폐렴 환자의 사망률과 림프구 하위 집합의 연관성Research Article Published on 2021-10-092022-09-10 Journal: Journal of Clinical Laboratory Analysis [Category] MERS, SARS, 바이오마커, [키워드] activated Admission admitted to ICU alteration B cell B lymphocyte B lymphocytes calculated CD2 CD3 CD38 CD4+ T cell CD4+ T cells CD5 CD7 CD8+ T cells Chain Reaction chance chest HRCT correlation COVID‐19 COVID‐19 infection COVID‐19 patients COVID‐19 demonstrated died evaluate evaluated expression flow cytometry HLA‐DR ICU admission indicated investigated less Lymphocyte subset Lymphocytes marker Mortality Patient Peripheral blood Pneumonia Predictive Predictive value Pulmonary infection pulmonary infections Result RT‐PCR severity significantly higher subgroup surface marker survived T and B lymphocytes T cell T cells T lymphocyte T lymphocytes these cell These cells variable was performed [DOI] 10.1002/jcla.24046 PMC 바로가기 [Article Type] Research Article
Sex-based clinical and immunological differences in COVID-19Covid-19의 성별 기반 임상 및 면역 학적 차이Research Article Published on 2021-07-052022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, [키워드] 95% confidence interval abnormality acute respiratory syndrome acute respiratory syndrome coronavirus adjusted hazard ratio Analysis antibody Antibody Response B cell B cells CD19 CD19+ CD4+ T cell CD4+ T cells change chemiluminescence clinical outcomes Clinical practice close monitoring Comparative analysis coronavirus Course COVID-19 COVID-19 patient COVID-19 patients Cytokines Cytometry death disease course female female patient Female patients females Flow flow cytometry gradually increased Hospitalization ICU admission IgG level IgG levels immune cells immunological Immunological response immunology independent risk factor indolent Inflammation Inflammatory cytokine Inflammatory cytokines lymphocyte lymphocyte subgroup lymphocyte subgroups Lymphocyte subset Lymphocyte subsets Lymphocytes male Male sex medical intervention Mortality nucleoprotein Pathogens Patient patients performed Peripheral blood Prognosis Protective Protein RBD-specific IgG reached Receptor binding domain renal respiratory Result SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Sex single center specific IgM spike Spike protein supplementary material survival analysis symptom onset T cells the disease Trial were measured [DOI] 10.1186/s12879-021-06313-2 PMC 바로가기 [Article Type] Research Article