Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunityArticle Published on 2023-07-192024-09-05 Journal: Cell Reports [Category] update2024, [키워드] Antigen presentation CD4+ T cells coronavirus COVID-19 Crystallography HLA class II Immune escape immune memory SARS-CoV-2 T cells [DOI] 10.1016/j.celrep.2023.112827 PMC 바로가기 [Article Type] Article
Emerging Effects of IL-33 on COVID-19Review Published on 2022-11-072023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] CD4+ T cells CD8+ T cells COVID-19 dendritic cells IL-33 innate lymphocytes macrophages Neutrophils Th17/Treg cells [DOI] 10.3390/ijms232113656 PMC 바로가기 [Article Type] Review
Immune response induced by novel coronavirus infectionReview Published on 2022-10-252023-07-10 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), [키워드] acquired immunity CD4+ T cells CD8+ T cells immune memory Innate immunity SARS-CoV-2 signaling pathways [DOI] 10.3389/fcimb.2022.988604 PMC 바로가기 [Article Type] Review
Narcolepsy and H1N1 influenza immunology a decade later: What have we learned?Review Published on 2022-10-122023-06-14 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] CD4+ T cells H1N1 influenza Hypocretin Narcolepsy Pandemrix Vaccine [DOI] 10.3389/fimmu.2022.902840 PMC 바로가기 [Article Type] Review
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responsesArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adaptive immunity CD4+ CD4+ T cell CD4+ T cells CD8+ T cell Cell Cellular immune response characteristic characterization circulating correlated COVID-19 demonstrated detectable dose Efficacy follicular full-length SARS-CoV-2 functional humoral immune responses IFN-γ immune immunization immunology individual induce magnitude Matrix-M NVX-CoV2373 Protective Protein response responses robust SARS-CoV-2-neutralizing antibody spike trimer subset T cells Th1 cell trials vaccinated individual vaccination Vaccine [DOI] 10.1172/JCI160898 PMC 바로가기
Immune Determinants of Viral Clearance in Hospitalised COVID-19 Patients: Reduced Circulating Naïve CD4+ T Cell Counts Correspond with Delayed Viral ClearanceArticle Published on 2022-09-022022-11-15 Journal: Cells [Category] SARS, 진단, [키워드] antibody B cell basophils CD4 T cells CD4+ CD4+ T cell CD4+ T cells cellular component correlated count COVID-19 Critical cytokine profile Delayed determinant disease deterioration help hospitalised patient Humoral response IL-9 immune activation immune parameter less longitudinal design magnitude MIF moderate Monocytes naïve naïve CD4+ T cell neutralising Neutralising Antibodies Neutrophils pro-inflammatory risk stratification SARS-CoV-2 SARS-COV-2 infection severe COVID-19 severe disease T cell Th2 the timing tissue damage viral clearance [DOI] 10.3390/cells11172743 PMC 바로가기
Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in people living with HIV: A cross-sectional studyHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 면역원성과 안전성: 단면 연구Article Published on 2022-09-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Analysis antibody Antiretroviral therapy appear ART CD4+ T cell CD4+ T cells CD4+ T-cell chemiluminescence Chinese control group COVID-19 COVID-19 vaccine cross-sectional delta variant Delta variants detect Efficacy and safety enzyme enzyme immunoassay healthy individual Human immunodeficiency virus IgG IgM antibodies IgM antibody immunoassay immunodeficiency immunogenicity inactivated indicated individual Mild multivariable analysis NAb Neutralizing neutralizing antibody Odds ratio PLWH proportion Safe SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine SARS-CoV-2-specific IgG self-limiting seropositive Seropositivity serum IgG serum levels Side effect Side effects significantly higher T cells titers vaccination was used wild-type SARS-CoV-2 with HIV [DOI] 10.1002/jmv.27872 PMC 바로가기 [Article Type] Article
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Research Published on 2022-07-282022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, 치료법, [키워드] acute infection acute respiratory distress Amino acid Analysis Applying ARDS carbon source CD4+ T cell CD4+ T cells COVID-19 Glycolysis highlight host adaptation immune response Impaired individual induce infected with SARS-CoV-2 infections influence interferon-γ ketogenic metabolism mice Mortality oxidative phosphorylation Patient promote provide Pulmonary infection pulmonary viral reducing severe COVID-19 severe respiratory infections skewed survival syndrome T cell T cell dysfunction T cell response [DOI] 10.1038/s41586-022-05128-8 [Article Type] Research
Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA VaccinePfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필Article Published on 2022-07-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19 [DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article