Cytokine storm and histopathological findings in 60 cases of COVID-19-related death: from viral load research to immunohistochemical quantification of major players IL-1β, IL-6, IL-15 and TNF-α사이토카인 폭풍과 COVID-19 관련 사망 사례 60건의 조직병리학적 발견: 바이러스 부하 연구에서 주요 선수 IL-1β, IL-6, IL-15 및 TNF-α의 면역조직화학적 정량화에 이르기까지Original Article Published on 2021-08-312022-09-11 Journal: Forensic Science, Medicine, and Pathology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar capillary antibody ARDS Autopsies Autopsy CD20 CD4 CD45 CD8 Cell collected control group COVID-19 COVID-19 group COVID-19 related-death current cytokine Cytokine storm Cytokines death Endothelial cell endothelial cells evaluate Evidence expressed expression fibrinogen histological analysis histopathological finding Hypothesis IL-10 IL-15 IL-1β IL-6 immunohistochemical staining immunohistochemistry immunoreactivity inflammatory cell inflammatory cells Inflammatory cytokine lung MCP-1 multiple cytokine multiple cytokines multiple organ failure nasopharynx nucleoprotein organs oropharynx outcomes overexpression Pneumonia positive Proinflammatory cytokine proinflammatory cytokines quantification Research respiratory respiratory distress RT-PCR SARS-CoV-2 SARS-CoV-2 RT-PCR selected Spike protein Swab swabs syndrome T cells tested the spike protein tissue TNF-α Trachea Viral load virus [DOI] 10.1007/s12024-021-00414-9 PMC 바로가기 [Article Type] Original Article
Effects of Steroids and Tocilizumab on the Immune Response Profile of Patients with COVID-19-Associated ARDS Requiring or Not Veno-Venous Extracorporeal Membrane OxygenationArticle Published on 2021-08-092022-10-31 Journal: Membranes [Category] COVID-19, [키워드] absence acute respiratory distress syndrome analyzed ARDS association B lymphocytes basophil both groups CD19 CD3 CD4 CD45 CD8 complicate concomitant therapy COVID-19 COVID-19 patient Critically ill drug ECMO Effect evaluate Extracorporeal extracorporeal membrane oxygenation immunomodulatory drugs increase in Inflammation Inflammatory leukocyte leukocytes lymphocyte lymphocyte subpopulation Lymphocytes lymphocytopenia marker Modification Monocytes Neutrophils NK cell Patient procalcitonin profile reduce reduced reducing reduction reduction in regression models required respiratory response SARS-CoV-2 pneumonia significantly steroid Steroids subpopulation Support Th cell therapy Tocilizumab trajectory Treatment VV-ECMO [DOI] 10.3390/membranes11080603 PMC 바로가기 [Article Type] Article
Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting PeptideMedicine Published on 2021-08-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Activation acute respiratory syndrome bind Breast cancer CD45 Cell Coronavirus-2 COVID-19 COVID-19 patient demonstrated function healthy volunteers Hypothesis immune Immune suppression immune system Immunosuppression in viral inhibited interfere intracellular signaling leukocytes modulating mononuclear cell novel Patient patients PBMC PBMCs peptide Peripheral blood Phosphorylation potential therapeutic target predominant Protein reported required rescued SARS-CoV-2 Signaling signaling pathway similarity Src family of tyrosine kinases T cell receptor targeting tested therapeutic transmembrane tyrosine tyrosine phosphatase virus [DOI] 10.3389/fmed.2021.675963 PMC 바로가기 [Article Type] Medicine
Detection of IFNγ-Secreting CD4 + and CD8 + Memory T Cells in COVID-19 Convalescents after Stimulation of Peripheral Blood Mononuclear Cells with Live SARS-CoV-2살아있는 SARS-COV-2를 갖는 말초 혈액 단핵 세포의 자극 후 COVID-19 COVALESCERS에서 IFNγ- 분비 CD4 + 및 CD8 + 메모리 T 세포의 검출Brief Report Published on 2021-07-292022-09-10 Journal: Viruses [Category] SARS, 치료기술, [키워드] causative agent CCR7 CD4 CD45 CD45RA CD8 Cell Cellular immune response cellular immune responses Characteristics circulating circulation collected convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescents COVID-19 pandemic Cytotoxic T cell Cytotoxic T cells detection effector memory Epitopes flow cytometry Human IFNγ Immune cell immune cells immune responses Immunity information intracellular cytokine staining live SARS-CoV-2 memory T-cell response memory T-cell responses Multiple Multiple studies natural infection New New coronavirus new coronavirus SARS-CoV-2 PBMC PBMCs peptide peptide pool peptide pools peptides peripheral persistence phenotype pool Quantitative SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines significant level Stimulation sucrose T cell T cells T-cell T-cell epitopes T-cell immunity T-cell memory T-cell responses T-helper long-lived immunity the disease These data Viral Viral proteins [DOI] 10.3390/v13081490 PMC 바로가기 [Article Type] Brief Report
RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiotaRS-5645는 폐 미생물총을 조절하여 SARS-CoV-2 스파이크 단백질 및 LPS에 의해 유도된 염증성 사이토카인 폭풍을 약화시킵니다Research Paper Published on 2021-07-252022-09-10 Journal: International Journal of Biological Sciences [Category] SARS, 바이오마커, [키워드] 16S rRNA 4-(thiophen-3-yl)-1-(p-tolyl)-1H-pyrrol-3-yl)(3,4,5-trimethoxyphenyl)methanone (RS-5645) abundance Activation addition alveolar alveoli Amino acid amino acid metabolism Analysis attenuate biogenesis cause of death CD11b CD45 CD56 CD56+ cellular COVID-19 patients Critically ill cytokine death elevated exhibited expression Host IFNγ indicated Inflammatory inflammatory cell inflammatory cell infiltration inflammatory cells Inflammatory cytokine Inflammatory cytokine storm inflammatory factor storm inflammatory storm inhibited Intervention involved KEGG LPS lung tissue manifested metabolism metabolite mice microbiota microorganism microorganisms modulating mononuclear cell mononuclear cells mRNA mRNAs overlapping Pathways PBMCs Peripheral blood Peripheral blood mononuclear cells Protein pulmonary microbiota qPCR reduce reduced Research rRNA S protein SARS-CoV-2 (COVID-19) spike protein SARS-CoV-2 spike SARS-CoV-2 spike protein Secondary Metabolite severely and critically ill COVID-19 patients significantly Streptococcus the S protein the SARS-CoV-2 translation unique [DOI] 10.7150/ijbs.63329 PMC 바로가기 [Article Type] Research Paper
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis InsightsSARS-CoV-2 감염은 JAK 길항 작용에 의한 건선성 관절염 발적 및 유착 상주 형질세포양 수지상 세포 유형-1 인터페론 억제를 유도하여 새로운 척추관절염 발병 통찰력 제공Immunology Published on 2021-04-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, [키워드] activated Activation antagonism Arthritis arthropathy Blood CD45 CD45+ cells characterized COVID-19 COVID-19 infection CpG DEGs dendritic dendritic cell dendritic cells differentially expressed gene Elevation enthesis evaluate evaluated flare Gene Expression IFNα imiquimod Infection inhibition insight interferon Interferon alpha interferon response investigated Jak JAK/STAT signaling pathway maturation mechanism microbe microbes modulation NF-κB NF-κB signaling normal novel objective occurred Pathway analysis pDC pDCs plasmacytoid dendritic cell plasmacytoid dendritic cells Protein psoriatic arthritis resident Result RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection Signaling significantly spondyloarthritis STAT stimulated suppressed therapeutic TLR-7 TNF Tofacitinib Toll-like receptor toll-like receptor signaling Trigger triggered triggers upregulated Viral viral infection was performed [DOI] 10.3389/fimmu.2021.635018 PMC 바로가기 [Article Type] Immunology
Multidimensional Proteomic Approach of Endothelial Progenitors Demonstrate Expression of KDR Restricted to CD19 Cells내피 전구체의 다차원 단백질체 접근은 CD19 세포로 제한된 KDR의 발현을 보여줍니다Clinical Trial Published on 2021-04-012022-08-31 Journal: Stem cell reviews and reports [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 임상, [키워드] absence Abstract approach artificial heart B-lymphocyte B-lymphocytes Bioprosthetic total artificial heart Blood C-kit cadherin candidate cardiovascular disease cardiovascular diseases CD133 CD14 CD19 CD34 CD45 Cell cell population cells cellular circulating circulation classic complementary Cord blood COVID-19 COVID-19 severity Critical critical COVID-19 patient cytometric Cytometry demonstrated described Elimination endothelial Endothelial progenitor cell Endothelial progenitor cells Endothelial progenitors evaluate events expresse expressed expressing expression Flow flow cytometry healthy imaging immature induce involved KDR lead Lineage Lymphocytes marker moderate monocyte Monocytes multidimensional one patient Patient performed Peripheral blood phenotype Population positive cell progenitor progenitor cell progenitor cells proteomic quantified redistribution Restricted Single Cell STEM stem cell stem cells subpopulation subset Subtypes vasculogenesis VE-cadherin VEGFR-2/KDR. [DOI] 10.1007/s12015-020-10062-1 PMC 바로가기 [Article Type] Clinical Trial
Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disordersReview Published on 2021-03-182022-10-29 Journal: Stem Cell Research & Therapy [Category] COVID-19, SARS, [키워드] adipocyte adipose Bone marrow CD105 CD14 CD34 CD45 CD73 Cell cell type chemokines chondrocyte conditions Coronavirus disease 2019 (COVID-19) COVID-19 criteria Crohn’s disease Culture Cytokines disease disorder disorders effective eligible evaluated exceptional expression feature global scientific community Graft versus host diseases (GVHD) GVHD HLA-DR homing Host identify Immune cell Immune-mediated immunomodulatory in vitro Infectious disease infiltration Inflammatory response involved ISCT lack leucocyte Mesenchymal stem/stromal cells (MSCs) Migration modulate molecular mechanism MSC MSCs multiple sclerosis Multiple sclerosis (MS) novel coronavirus disease Osteoarthritis Osteoarthritis (OA) over pathway Patient plasticity recent finding regulated released required Secretome signaling molecule Society Source suggested synergy target cell therapeutic Therapeutic molecule therapeutic option tissue Treatment umbilical [DOI] 10.1186/s13287-021-02265-1 PMC 바로가기 [Article Type] Review
The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial중증 코로나19 환자에서 중간엽 줄기세포 치료의 체계적인 효과: 전향적 이중 대조 시험Controlled Clinical Trial Published on 2021-01-012022-09-11 Journal: Cell transplantation [Category] 유전자 메커니즘, 임상, [키워드] Analysis anti-inflammatory cytokine anti-inflammatory cytokines Apoptosis Biochemical parameters CD16 CD19 CD3 CD4 CD45 CD56 CD8 Cell cellular chemokines clinical manifestation clinical manifestations clinical trial Controlled COVID-19 COVID-19 patient COVID-19 patients Critical critical cases Critically ill critically ill COVID-19 patients critically ill patients CRP level CRP levels cytokine Cytokine storm Cytokines demonstrated died dose Effect evaluate evaluated fibrinogen group groups growth growth factor Growth factors HLA-DR IFNγ IL-10 IL-12 IL-13 IL-17A IL-1ra IL-2 IL-6 immunomodulatory effect immunomodulatory effects intravenously investigated KGF lymphocyte Lymphocyte subsets marker matrix metalloproteinases mechanism of action mesenchymal stem cell Mesenchymal stem cells moderate MSC MSCs Neutrophils NGF overall mortality Patient positive proinflammatory proinflammatory cytokines Prospective reducing mortality separated Serum ferritin significantly statistical STEM stem cell TGF-β the cytokine storm therapy tissue regeneration treated Treatment VEGF [DOI] 10.1177/09636897211024942 PMC 바로가기 [Article Type] Controlled Clinical Trial
Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: A retrospective cohort studyTanreqing Capsule이 COVID-19 환자에서 핵산의 음성 전환 시간에 미치는 영향: 후향적 코호트 연구Article Published on 2021-01-012022-08-31 Journal: Journal of integrative medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] addition Administered Capsule CD3 CD4 CD45 center Chinese clinical Clinical efficacy complement conducted control group control groups coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnostic testing COVID-19 patient COVID-19 patients diagnostic diagnostic testing disease Effect fecal hospital immune laboratory-confirmed mechanism Mild moderate Moderate COVID-19 negative Negative conversion Negative conversion rate nucleic acid pandemic Patient pharyngeal Pharyngeal swab Public reductions in retrospective cohort study Shanghai Shanghai Public Health Clinical Center Significant significant reductions statistically significant difference subset T cell T cells T-cell Tanreqing Capsule. the median Therapeutic benefit Traditional Traditional Chinese medicine treated Treatment treatment group was used [DOI] 10.1016/j.joim.2020.10.002 PMC 바로가기 [Article Type] Article