SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular CytotoxicitySARS-CoV-2 액세서리 단백질 ORF8은 항체 의존성 세포 세포 독성을 감소시킵니다Article Published on 2022-06-072022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Accessory accessory protein accessory proteins ADCC addition antibody-dependent cellular cytotoxicity bind CD16 CD8+ T cell coronavirus decrease disease evade Fc-mediated effector function help host immune responses humoral responses identify immune evasion monocyte Monocytes mononuclear cell mutate nanomolar affinity Neutralizing antibodies NK cells ORF8 PBMC Peripheral blood Protein reduce reducing SARS-CoV-2 SARS-CoV-2-infected cell significantly spike susceptibility [DOI] 10.3390/v14061237 PMC 바로가기 [Article Type] Article
Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination Research Published on 2022-06-012022-10-05 Journal: Nature Communications [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adjusted Blood Ccr6 CD107a CD4+ cell CD4+ T cell CD8+ T cell Cell clinical trials contribute COVID-19 vaccination COVID-19 vaccine Cytokines decrease Donor doses Efficacy elevate expansion expressing expression flow cytometry increase in increases in less linear memory mRNA nasal nasal mucosa Pfizer-BioNTech phenotype protective immunity SARS-CoV-2 SARS-CoV-2 spike peptide second dose shown Stimulation subset Swab T cell upper respiratory tract vaccination Vaccine vaccine dose Vaccines [DOI] 10.1038/s41467-022-30913-4 [Article Type] Research
SARS-CoV-2 DNA Vaccine INO-4800 Induces Durable Immune Responses Capable of Being Boosted in a Phase 1 Open-Label TrialSARS-CoV-2 DNA 백신 INO-4800, 1상 공개 라벨 시험에서 강화될 수 있는 내구성 면역 반응 유도Clinical Trial Published on 2022-06-012022-09-12 Journal: The Journal of Infectious Diseases [Category] Coronavirus, COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] activated acute respiratory syndrome Adults adverse event age Antibody Response Antigen being booster booster dose CD8+ T cell clinical clinical trial coronavirus coronavirus disease COVID-19 DNA DNA vaccine dosage dose effective Electroporation evaluated Frequency full-length healthy homologous immune response immune responses immunogenicity increase in INO-4800 intradermal injection Mild MOST pandemic Participants Phase 1 primary dose response Safe Safety SARS-CoV-2 second dose Serious Adverse Events significantly increased subsequent Support T cell Trial Vaccine [DOI] 10.1093/infdis/jiac016 PMC 바로가기 [Article Type] Clinical Trial
Dysregulated Immune Responses in SARS-CoV-2-Infected Patients: A Comprehensive OverviewSARS-CoV-2 감염 환자의 조절되지 않은 면역 반응: 종합 개요Review Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus adaptive alteration Antigen antigen-presenting cell antiviral immune responses B cell subset Biomarker caused CD8+ CD8+ T cell cellular cellular immunity complications of COVID-19 Comprehensive comprehensive analysis coronavirus country COVID-19 COVID-19 patients disease effective evade follicular follicular Th cell help Host Human humoral Humoral immunity identify immune responses Immunity IMPROVE Infection Inflammatory information innate and adaptive immunity involved knowledge mechanism molecular mechanism monocyte new virus outcomes pathological change pathological changes Phenotypes Post-COVID-19 syndrome predict recognize Research response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Symptom syndrome T cell Th cell Th cell subsets Th17 the SARS-CoV-2 variety [DOI] 10.3390/v14051082 PMC 바로가기 [Article Type] Review
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigensCD8+ T 세포 병원성 에피토프 및 암 신생항원 예측에서 기존 컴퓨터 모델의 성능 평가Article Published on 2022-05-132022-09-12 Journal: Briefings in Bioinformatics [Category] MERS, 진단, [키워드] acute respiratory syndrome binding affinity Cancer cancer neoantigen cancers CD8 T-cell CD8 T-cell target CD8+ T cell coronavirus disease distribution epitope evaluated Evaluating Evidence facilitate Factor feature highlight histocompatibility complex HLA ligand immunogenic immunogenic peptide immunotherapies Immunotherapy Intensive long-term immune responses malignant cell modulate offer parameter pathogen pathogenic pathology peptide peptide immunogenicity peptide presentation peptides predictors question random Research robust stability suggested T cell T cell receptor T-cell T-cell Response target threshold training data Vaccine Variation virus [DOI] 10.1093/bib/bbac141 PMC 바로가기 [Article Type] Article
Limited T cell response to SARS-CoV-2 mRNA vaccine among patients with cancer receiving different cancer treatments다른 암 치료를 받는 암 환자에서 SARS-CoV-2 mRNA 백신에 대한 제한된 T 세포 반응Article Published on 2022-05-012022-09-12 Journal: European journal of cancer (Oxford, England : 1990 [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] administration adverse event anti-S anti-S IgG blood sample Cancer cancer treatment CD4+ CD4+ T cell CD8+ CD8+ T cell cellular response Chemotherapy collected complement complications conducted control group COVID-19 COVID-19 case cut-off defined demonstrated determine develop diagnose dose driven by enrolled first dose follow-up period HCW Health care worker high risk humoral Humoral response Immunotherapy inhibitor involved kinase Limited magnitude mRNA vaccine mRNA-1273 mRNA-1273 vaccine Patient patient reported outcome Patients with cancer receiving reported SARS-CoV-2 second dose significantly higher significantly lower single-center study Solid solid tumour Solid tumours T cell response T cells treated vaccination Vaccine vaccine dose [DOI] 10.1016/j.ejca.2022.02.017 PMC 바로가기 [Article Type] Article
Markers of Memory CD8 T Cells Depicting the Effect of the BNT162b2 mRNA COVID-19 Vaccine in Japan일본에서 BNT162b2 mRNA COVID-19 백신의 효과를 나타내는 메모리 CD8 T 세포의 마커Article Published on 2022-04-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Affect anti-S antibody Antibody titers Antigen BNT162b2 BNT162b2 mRNA BNT162b2 vaccine boost CD107a CD38 CD8 CD8, vaccine CD8+ cell CD8+ cells CD8+ T cell CD8+ T cells Cell Cellular immune response cellular immune responses cellular immunity COVID-19 CTL Effect effector cell effector cells Efficacy elicit elicited environmental factor evaluate expression female Frequency function functions Genetic granzyme B immune responses intensity investigated Japan Japanese KLRG1 male males marker markers memory memory CD8+ T cells mRNA vaccination nucleoside nucleoside-modified mRNA pentamer positive cells positively correlated precursor proliferation Protein provide response S protein SARS-CoV-2 spike glycoprotein second vaccination serum Sex difference spike glycoprotein T cell T cell proliferation T cells Vaccine was increased [DOI] 10.3389/fimmu.2022.836923 PMC 바로가기 [Article Type] Article
Vaccine protection against the SARS-CoV-2 Omicron variant in macaques원숭이의 SARS-CoV-2 오미크론 변종에 대한 백신 보호Article Published on 2022-04-282022-09-11 Journal: Cell [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine Adenovirus antibody Antibody titer Antibody titers B.1.1.529 BNT162b2 BNT162b2 vaccine Bronchoalveolar lavage CD8+ T cell Cellular immune response contribute correlated cynomolgus macaques demonstrated Efficacy heterologous prime-boost High-dose homologous humoral immune responses macaque macaque. moderate mRNA mRNA-based mutated nasal swabs neutralizing antibody titers omicron populations question raised regimen respiratory response robust SARS-CoV-2 SARS-CoV-2 variant Spread T cell T cell responses the SARS-CoV-2 These data undetectable upper respiratory tract Vaccine Vaccines variant virus [DOI] 10.1016/j.cell.2022.03.024 PMC 바로가기 [Article Type] Article
Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriersArticle Published on 2022-04-202023-06-13 Journal: BMC Immunology [Category] B형 간염, [키워드] CD8+ T cell CXCR5 Exhaustion flow cytometry HBV. [DOI] 10.1186/s12865-022-00488-2 PMC 바로가기
SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells Research Published on 2022-04-052022-10-05 Journal: Nature Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome Antigen booster Breakthrough infection CD8+ T cell characterized coronavirus distribution Effect effectors Efficacy elicit Evidence Ex vivo expand exposure histocompatibility complex Human individual Infection memory memory T cell monoclonal motifs mRNA vaccine phenotype Primary infection protocol receptor repeated responses SARS-CoV-2 SARS-CoV-2 antigen sequence severe coronavirus disease Single-cell RNA sequencing specificity spike-specific T cell T cell T cell memory TCR vaccination variant [DOI] 10.1038/s41590-022-01184-4 [Article Type] Research