Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody AZD1222 booster vaccination cellular Cellular immune response cellular immune responses cellular immunity coronavirus COVID-19 Delta delta variant dose effective elevated elicit Emergency use authorization emerging variants evaluated Evidence Heterologous heterologous prime-boost heterologous vaccination humoral immune immune evasion immune response immune responses IMPROVE increase in induce Infection interferon mRNA mRNA vaccine mRNA-1273 Multiple Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevent priming promote Protein subunit protein subunit vaccine provided RBD Receptor binding domain reduced regimen response SARS-CoV-2 SARS-CoV-2 variants significantly subunit suggested T cell Taiwan vaccination vaccination schedule Vaccine variant variants Viral variants wild type [DOI] 10.1128/spectrum.00609-22 PMC 바로가기
Effectiveness of COVID-19 vaccination in healthcare workers in Shiga Prefecture, JapanArticle Published on 2022-10-212022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Abbott analyzed antibody Cell cells Cellular immune response cellular immunity conducted coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccinations Delta effective evaluated HCW HCWs health condition healthcare worker Hospitalization humoral induce Japan Poor questionnaire repeated required Roche SARS-CoV-2 SARS-COV-2 infection serological seropositive Standard deviation vaccination Vaccine Wuhan-1 [DOI] 10.1038/s41598-022-22682-3 PMC 바로가기
Humoral and cellular immune responses to CoronaVac up to one year after vaccinationArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] all subject Antibody Response Antiviral CD4^{+} T cell cellular Cellular immune response cellular response clinical trial CoronaVac cytokine production cytokine profile defined effector memory evaluated follicular humoral Humoral response immune immune memory immune response impacted Inactivated vaccine individual induce memory Older peaked Phase 3 response SARS-CoV-2 SARS-CoV-2-specific IgG SARS-CoV-2-specific immune responses second dose sustained T cell activation T cell phenotype Tfh Th2 vaccination vaccine dose vaccinees [DOI] 10.3389/fimmu.2022.1032411 PMC 바로가기
Assessing T-Cell Immunity in Kidney Transplant Recipients with Absent Antibody Production after a 3rd Dose of the mRNA-1273 VaccineArticle Published on 2022-10-152022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, [키워드] addition age analyzed antibody production Assessing association CD19+ CD3+ CD4+ CD8+ Cell-mediated immunity Cellular immune response Cohort complement Concentration COVID-19 COVID-19 vaccines dose effective Gender highlight humoral Humoral immunity IFN-γ immune independent variable interferon-gamma release assay kidney kidney transplant recipient Kidney transplantation Linear regression analysis lymphocyte mRNA-1273 mRNA-1273 vaccine patients positive Production recipient Responder SARS-CoV-2 SD Biosensor seronegative patient statistically significant Surveillance T cell response T cells tested Transplant [DOI] 10.3390/ijms232012333 PMC 바로가기
A third dose SARS‑CoV‑2 BNT162b2 mRNA vaccine results in improved immune response in hemodialysis patientsArticle Published on 2022-10-132022-11-15 Journal: Upsala Journal of Medical Sciences [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Abbott anti-S Antigen antivirals BNT162b2 mRNA vaccine Cellular immune response cellular response Chronic kidney disease coronavirus 2 coronavirus disease COVID-19 COVID-19 infection develop dose enrolled evaluated Hemodialysis humoral humoral and cellular immune response. IgG antibody immune response Immunological response ImmunoSpot Infection interquartile range IQR kidney Level median MONITOR monoclonal antibody mRNA pandemic Patient patients positive Protein reactivity respiratory respond robust SARS-CoV-2 SARS-CoV-2 BNT162b2 SARS-CoV-2 bnt162b2 mRNA vaccine T-cell T-cell Response the median the Spike the vaccine uremia vaccine dose Vaccines weaker immune response [DOI] 10.48101/ujms.v127.8959 PMC 바로가기
Long-term cellular immune response in immunocompromised unvaccinated COVID-19 patients undergoing monoclonal antibody treatmentArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome anti-SARS-CoV-2 Antigen cellular Cellular immune response cellular response clinical decision control groups Coronavirus-2 Course COVID-19 COVID-19 patient develop Effect ELISpot assay healthy control help High-risk patients immune Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppression increased risk Infection investigated mAb mAbs median monoclonal antibody monoclonal antibody treatment Patient patient cohorts SARS-CoV-2 SARS-COV-2 infection spike subject Treatment was determined [DOI] 10.3389/fimmu.2022.980698 PMC 바로가기
Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2Article Published on 2022-10-122022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated T cell antibodies antibody Antibody Response booster booster dose booster vaccination CD137 CD69 CD8 T cell Cellular immune response ChAdOx1-S conducted decrease dose expressing expression Frequency humoral IFN-γ immune response immunosuppressive increase in indicated Infection Injections lack longitudinal analysis memory monocyte mRNA mRNA vaccine myeloid cell omicron participant PD-L1 peptides phenotype producing protective immunity reactive reduced SARS-CoV-2 SARS-CoV-2-specific T cell T cell T cell response T cells the spike protein TNF-α upregulation vaccination Vaccinations Vaccine variant vector vaccine virus-specific T cell [DOI] 10.3389/fimmu.2022.1012526 PMC 바로가기
Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritisArticle Published on 2022-10-122022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] addition age anti-CD20 therapy anti-S anti-S antibody anti-SARS-CoV-2 antibodies antibody Antibody Response BNT162b2 cell-mediated response Cellular immune response cellular immune responses ChAdOx1 Concentration Corona covariate adjustment COVID-19 COVID-19 vaccine declined dependent on DMARD (disease-modifying antirheumatic drug treatment) domains dose enrolled Factor healthy controls humoral IL-6 inhibitor immune response Infection inhibited investigated IQR magnitude median time mRNA-1273 Patient patients patients treated peptides positive patient reduced respiratory rheumatoid arthritis RNA RNA vaccine SARS-CoV-2 significant effect significantly Specific specific antibodies specific antibody subject T-cell T-cell Response targeted therapy the healthy the interferon the SARS-CoV-2 the vaccine therapy vaccination Vaccine variables was measured were infected [DOI] 10.3389/fimmu.2022.960001 PMC 바로가기
Humoral and cellular immune response over 9 months of mRNA-1273, BNT162b2 and ChAdOx1 vaccination in a University Hospital in SpainArticle Published on 2022-10-072022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] antibody BNT162b2 booster vaccinations carried cellular Cellular immune response cellular immunity ChAdOx1 COVID-19 COVID-19 vaccination dose elimination half-life Follow-up healthcare worker Heterologous humoral Immunity individual infected individual inoculated mRNA-1273 naïve Naturally participant preserved Prospective Study receiving reported robust SARS-CoV-2 spike second dose single dose Spain T cell uninfected university vaccination Vaccine Validity [DOI] 10.1038/s41598-022-19537-2 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기