The importance of endothelial protection: the emerging role of defibrotide in reversing endothelial injury and its sequelaeReview Article Published on 2021-09-282022-10-04 Journal: Bone marrow transplantation [Category] 바이오마커, [키워드] Activation Anti-inflammatory anti-oxidative Antithrombotic approved Cancer CAR-T cell transplantation chimeric antigen receptor Clinical data clinical study condition Cytokine release syndrome defibrotide disease disorder downregulating downstream driven by dysfunction Effects endothelial Endothelial cell endothelial cell damage Endothelial dysfunction endothelial injury Endotheliitis Europe European Commission fibrinolytic Haematological cancer HCT hepatic homeostasis inhibiting Interaction MAPK membrane potentially life-threatening Protective Protein resulting Support syndrome T-cell the United State thrombotic utility [DOI] 10.1038/s41409-021-01383-x PMC 바로가기 [Article Type] Review Article
CAR-NK Cells Effectively Target SARS-CoV-2-Spike-Expressing Cell Lines In VitroCAR-NK 세포, 시험관 내에서 SARS-CoV-2-스파이크 발현 세포주를 효과적으로 표적화Immunology Published on 2021-07-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome coronavirus addition adverse effect Anticoagulants antigen receptor antivirals approach Cancer CAR CAR (chimeric antigen receptor) Cell cells chimeric antigen receptor conserved conserved region contagious convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CR3022 current cytokine cytokine production D614G domain E484K E484K variant effective Emergency use escape mutant escape mutants Evidence expressing glycoprotein hematologic immune pressure immune response Immunity immunocompromised condition immunodeficient patients immunomodulators Immunotherapy IMPROVE in vitro include individual isolates kill killing LINE Moderna monoclonal antibody monoclonal antibody therapies mutants N501Y N501Y variant NAbs natural killer neutralizing antibody NK cells off-the-shelf Patient Pfizer Population pseudotyped SARS-CoV-2 virus public health recognize reported respiratory S protein S309 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolates SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 virus scFv Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Side effect target target cell target cells the vaccines Therapies therapy treat treating COVID-19 Treatment Vaccine Vaccines variants of SARS-CoV-2 [DOI] 10.3389/fimmu.2021.652223 PMC 바로가기 [Article Type] Immunology
CAR Macrophages for SARS-CoV-2 ImmunotherapyImmunology Published on 2021-07-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] CAR CD3ζ Cell-based therapy cellular phagocytosis chimeric antigen receptor coronavirus disease COVID-19 COVID19 cytosolic Defense domain domains Effects expression function high risk human macrophage hyperinflammation in vitro individuals with COVID-19 invading pathogens killing Macrophage macrophages MEGF10 MERTK Phagocytic activity Proinflammatory cytokine receptor reduced SARS-CoV-2 SARS-CoV-2 clearance Severe case severe cases Treatment unique upregulation virion [DOI] 10.3389/fimmu.2021.669103 PMC 바로가기 [Article Type] Immunology
Editorial: Tocilizumab, a Humanized Therapeutic IL-6 Receptor (IL-6R) Monoclonal Antibody, and Future Combination Therapies for Severe COVID-19사설: Tocilizumab, 인간화 치료 IL-6 수용체(IL-6R) 단클론항체 및 중증 COVID-19에 대한 미래 조합 요법Editorial Published on 2021-07-192022-09-12 Journal: Medical science monitor : international medical jo [Category] 진단, [키워드] antibody approved authorization CAR chimeric antigen receptor clinical development clinical trial combination therapies combination treatment COVID-19 COVID-19 therapy CRS Cytokine release syndrome develop disease drug editorial Efficacy Emergency EUA FDA food Future giant cell arteritis Hospital admission hospitalized patient humanized humanized monoclonal antibody IL-6 IL-6 receptor IL-6R Immunosuppressed individual infected with SARS-CoV-2 juvenile idiopathic arthritis moderate monoclonal antibody Patient Proinflammatory cytokine recovery reduce REMAP-CAP rheumatoid arthritis SARS-COV-2 infection severe COVID-19 severity of COVID-19 supported systemic effect T-cell therapeutic Tocilizumab treat Treatment [DOI] 10.12659/MSM.933973 PMC 바로가기 [Article Type] Editorial
Successful Chimeric Antigen Receptor (CAR) T-Cell Treatment in Aggressive Lymphoma Despite Coronavirus Disease 2019 (CoVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication – Case ReportOncology Published on 2021-07-142022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] acute respiratory syndrome Administered Aggressive Anti-CD19 B-cell lymphoma CAR CAR-T cell cellular Chemotherapy chimeric antigen receptor Chimeric antigen receptor T-cells clinical recovery Complete coronavirus coronavirus 2 coronavirus disease Course COVID-19 cytokine release Deterioration diffuse large B-cell lymphoma disease early recovery feasible Hematological malignancies immune function Immunotherapy Infection lymphoma moderate offer Patient Pneumonia processed Prolonged report respiratory SARS-CoV-2 SARS-COV-2 infection T cell T-cell the SARS-CoV-2 therapeutic activity therapy Treatment Virus Disease [DOI] 10.3389/fonc.2021.706431 PMC 바로가기 [Article Type] Oncology
Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms사이토카인 폭풍에서 인터루킨-6 신호와 혈관 내피 사이의 상호작용Review Published on 2021-07-122022-09-12 Journal: Experimental & Molecular Medicine [Category] SARS, 진단, [키워드] abnormal coagulation activate Acute inflammation Affect anti-IL-6 receptor antibody Arthritis block blocking CAR-T cell therapy Cell characterized chemokine chimeric antigen receptor chronic inflammatory disease coagulation cascade coronavirus disease COVID-19 cytokine Cytokine storm Cytokine storms Defense demonstrated disease dysregulation Effect Evidence healthy help highlight Host humanized IL-6 IL-6 receptor IL-6 signaling immune response implicated indicate Infection inflammatory conditions Inflammatory response interleukin-6 Interleukins Japan management Pathogenesis recent receptors rheumatoid arthritis Sepsis shown Signaling signaling molecule spiral Stopping suppress systemic inflammation T-cell therapeutic potential therapeutic strategy tissue injury Tocilizumab Treatment university vascular endothelial cells Vascular endothelium vascular leakage [DOI] 10.1038/s12276-021-00649-0 PMC 바로가기 [Article Type] Review
Machine learning-based cytokine microarray digital immunoassay analysis머신러닝 기반 사이토카인 마이크로어레이 디지털 면역분석Article Published on 2021-05-152022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, [키워드] acutely ill patients Algorithm Analysis Antigen approach autonomous Biomarker CAR-T CAR-T therapy Cell Cell therapy chimeric chimeric antigen receptor CNN Combination Concentration Convolutional neural network COVID-19 patient Critical care Critically ill critically ill COVID-19 patients cytokine Cytokine release syndrome Cytokine storm syndrome Cytokines Data analysis develop Image analysis Immune status immunoassay longitudinal Longitudinal data machine machine learning Microarray Microfluidic digital immunoassay Multiplex biomarker detection. pathway Patient Protein protein concentrations receiving reduce reveal sampling sensitivity serum cytokine serum cytokines therapy unique Volume [DOI] 10.1016/j.bios.2021.113088 PMC 바로가기 [Article Type] Article
Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology
Tocilizumab treatment in critically ill patients with COVID-19: A retrospective observational study코로나19 중증 환자에 대한 토실리주맙 치료: 후향적 관찰 연구Observational Study Published on 2021-04-012022-09-12 Journal: International Journal of Infectious Diseases [Category] SARS, 임상, 진단, 치료법, [키워드] acute respiratory distress syndrome administration attenuate chimeric antigen receptor conducted COVID-19 COVID-19 patients Critically ill Critically ill patient Cytokine release syndrome Cytokine storm death disease severity distress dysregulated immune response group hospital hospital discharge intensive care interleukin-6 receptor Intubated invasive measurement mechanical ventilation not different on mechanical ventilation outcome Patient patients patients treated percentage Pneumonia pro-inflammatory cytokine progressed required Respiratory disease retrospective SARS-CoV2 Secondary infection severe COVID-19 infections subgroup of patient Tocilizumab treat Treatment venous [DOI] 10.1016/j.ijid.2021.02.057 PMC 바로가기 [Article Type] Observational Study
Immune cartography of macrophage activation syndrome in the COVID-19 era코로나19 시대 대식세포 활성화 증후군의 면역 지도 촬영Review Published on 2021-03-012022-09-11 Journal: Nature reviews. Rheumatology [Category] SARS, 변종, 유전자 메커니즘, [키워드] adaptive alveolitis antigen receptor Arthritis Cancer Cancer immunotherapy cancers CAR Cell therapy chimeric antigen receptor complex interplay Connective tissue diseases continuum COVID-19 COVID-19 pneumonia Cytokine storm develop disease disparate dominant feature Gain Gain of function genetics Hyperinflammatory hypersensitivity immune immune function Immunity immunodeficiency immunological immunological disease immunothrombosis Implications in some Infection infectious innate and adaptive immunity innate immune juvenile idiopathic arthritis limit limits Macrophage macrophage activation syndrome MHC class MHC class II occur offer patients with COVID-19 Pneumonia provide responses second wave Sepsis severe inflammation Still T cell therapeutic therapy Trigger triggers type I interferon variant [DOI] 10.1038/s41584-020-00571-1 PMC 바로가기 [Article Type] Review